Protein Information

Name superoxide dismutase
Synonyms IPO B; Indophenoloxidase B; MNSOD; Manganese superoxide dismutase; Manganese containing superoxide dismutase; Mangano superoxide dismutase; Mn superoxide dismutase; Mn SOD…

Compound Information

Name thiram
CAS

Reference List

PubMed Abstract RScore(About this table)
11875743 Marikovsky M: Thiram inhibits angiogenesis and slows the development of experimental tumours in mice. Br J Cancer. 2002 Mar 4;86(5):779-87.

Moreover, thiram had markedly inhibited human recombinant Cu/Zn superoxide dismutase enzymatic activity (85%) in vitro.
168(2,2,3,3) Details
17728093 Grosicka-Maciag E, Kurpios D, Czeczot H, Szumilo M, Skrzycki M, Suchocki P, Rahden-Staron I: Changes in antioxidant defense systems induced by thiram in V79 Chinese hamster fibroblasts. Toxicol In Vitro. 2008 Feb;22(1):28-35. Epub 2007 Jul 26.

Pretreatment with N-acetyl cysteine (NAC), a GSH precursor, prevented enzymatic changes in CAT, Se-dependent GSH-Px, GR, SOD1 activities, and significantly decreased SOD2 activity following exposure to thiram.
7(0,0,1,2) Details
19365751 Panemangalore M, Bebe FN: Short- and long-term exposure to low levels of pesticide and flavonoid mixtures modify endogenous antioxidants in tissues of rats. J Environ Sci Health B. 2009 May;44(4):357-64.

Two experiments were conducted using dietary flavonoid (F) and oral pesticide (P) mixtures (FM, PM) on changes in the activities of superoxide dismutase (SOD), glutathione peroxidase (GPX) and glutathione concentrations (GSH) in male Sprague Dawley rats (150-175 g) fed for 2 or 4 weeks the AIN 93M diet with or without equal amounts of quercetin, rutin, catechin (FM) at 1.0 mM or 5 mM/kg diet, and with/without PM fed orally at 0.1 mL/d/5d/wk (PM = chlorpyrifos, endosulfan, thiram at 25% LD (50) in oil).
6(0,0,1,1) Details
16190021 Bebe FN, Panemangalore M: Pesticides and essential minerals modify endogenous antioxidants and cytochrome P450 in tissues of rats. J Environ Sci Health B. 2005;40(5):769-84.

Two experiments were conducted in male Sprague Dawley (SD) rats (175-200 g) to determine changes in the activities of endogenous antioxidants superoxide dismutase (SOD), glutathione peroxidase (GPX), cytochrome P450 (ethoxyresorufin deethylase; EROD) and concentrations of glutathione (GSH) in the blood, liver, and small intestinal mucosa (IM).
In both experiments, six rats/group were fed diets based on the AIN-93M diet (Control) or the same modified to contain either 500 mg calcium (Low Ca), 7 mg Zn (Low Zn): 2 mg copper (Low Cu), 60 mg zinc (High Zn) or 12 mg copper (High Cu) in the following combination: Control, LCa/LZn, LCa/LZn/LCu, or HZn/HCu, with and without a pesticide mixture containing acephate, endosulfan, and thiram at 25% LD50 for four or two weeks.
1(0,0,0,1) Details
18085455 Li J, Bi D, Pan S, Zhang Y: Effect of diet with thiram on liver antioxidant capacity and tibial dyschondroplasia in broilers. Br Poult Sci. 2007 Dec;48(6):724-8.

At the end of the trial, broilers were killed and liver samples were collected to determine the activity of SOD (superoxide dismutase), GSH-Px (glutathione peroxidase) and MDA (malondialdehyde) content, while the right proximal tibiotarsi were dissected in longitudinal section for assessment of tibial dyschondroplasia (TD) incidence and TD score. 4.
1(0,0,0,1) Details
8363496 Wu W, Cook ME, Chu Q, Smalley EB: Tibial dyschondroplasia of chickens induced by Fusarochromanone, a mycotoxin. Avian Dis. 1993 Apr-Jun;37(2):302-9.


Cartilage mineral profiles in FC- or Thiram-induced TD differed from that of 1-day-old hypertrophic embryonic cartilage core (less K and Mn).
0(0,0,0,0) Details