Protein Information

Name albumin
Synonyms ALB; Albumin; PRO0883; PRO0903; PRO1341; PRO1708; PRO2044; PRO2619…

Compound Information

Name diazinon
CAS

Reference List

PubMed Abstract RScore(About this table)
18484351 Tarhoni MH, Lister T, Ray DE, Carter WG: Albumin binding as a potential biomarker of exposure to moderately low levels of organophosphorus pesticides. Biomarkers. 2008 Jun;13(4):343-63.

At pesticide exposures producing approximately 30% inhibition of AChE, rat plasma albumin binding in vitro by azamethiphos (oxon), chlorfenvinphos (oxon), chlorpyrifos-oxon, diazinon-oxon and malaoxon was reduced from controls by 9+/-1%, 67+/-2%, 56+/-2%, 54+/-2% and 8+/-1%, respectively.
90(1,1,1,10) Details
15925023 Kalender S, Ogutcu A, Uzunhisarcikli M, Acikgoz F, Durak D, Ulusoy Y, Kalender Y: Diazinon-induced hepatotoxicity and protective effect of vitamin E on some biochemical indices and ultrastructural changes. Toxicology. 2005 Aug 1;211(3):197-206. Epub 2005 Apr 19.

It was observed that; at the end of 1st week, there was a statistically significance in all parameters except total protein and albumin, and at the end of 4th and 7th weeks, there was a statistically significance in all parameters when diazinon-treated group compared to control group (P <0.01).
7(0,0,1,2) Details
17615116 Carter WG, Tarhoni M, Rathbone AJ, Ray DE: Differential protein adduction by seven organophosphorus pesticides in both brain and thymus. Hum Exp Toxicol. 2007 Apr;26(4):347-53.

We found significant adduction of partially characterized protein targets in both rat brain and thymus by azamethiphos, chlorfenvinphos, chlorpyrifos-oxon, diazinon-oxon, dichlorvos and malaoxon, in vitro and pirimiphos-methyl in vivo.
However, some adducted proteins are also expressed in blood, notably albumin, and so may provide exposure measures to increase the power of future epidemiological studies.
1(0,0,0,1) Details
11673119 Qiao D, Seidler FJ, Slotkin TA: Developmental neurotoxicity of chlorpyrifos modeled in vitro: comparative effects of metabolites and other cholinesterase inhibitors on DNA synthesis in PC12 and C6 cells. Environ Health Perspect. 2001 Sep;109(9):909-13.

Diazinon, another organophosphate pesticide, also inhibited DNA synthesis with preference toward C6 cells, but was less effective than was chlorpyrifos.
We also found that the addition of sera protected the cells from the adverse effects of chlorpyrifos and that the effect could be reproduced by addition of albumin.
1(0,0,0,1) Details
12739808 Hanna LS, Medhat AM, Abdel-Menem HA: Effect of diazinon and/or praziquantel on selected protein aspects in healthy and Schistosoma mansoni infected mice. J Egypt Soc Parasitol. 2003 Apr;33(1):145-62.

The results showed that non significant differences were obtained from total proteins, albumin, globulins, and albumin/globulin ratio.
1(0,0,0,1) Details