Protein Information

Name brains
Synonyms BPG dependent PGAM 1; Brain; CDABP0006; PGAM 1; PGAM B; PGAM1; PGAM1 protein; PGAMA…

Compound Information

Name diazinon
CAS

Reference List

PubMed Abstract RScore(About this table)
2023308 Prijono WB, Leighton FA: Parallel measurement of brain acetylcholinesterase and the muscarinic cholinergic receptor in the diagnosis of acute, lethal poisoning by anti-cholinesterase pesticides. J Wildl Dis. 1991 Jan;27(1):110-5.

The activity of acetylcholinesterase (AChE) and the density of muscarinic cholinergic binding receptors (mCBR) were measured in brains from normal Japanese quail (Coturnix coturnix japonica) and from quail after lethal intoxication with diazinon.
63(0,2,2,3) Details
3952746 Chow E, Seiber JN, Wilson BW: Isofenphos and an in vitro activation assay for delayed neuropathic potential. Toxicol Appl Pharmacol. 1986 Mar 30;83(1):178-83.

The compounds (0.1 mM or less) to be tested were incubated with microsomes isolated from livers of phenobarbital-treated chick embryos (P-450 content averaged 1.81 +/- 0.27 nmol/mg protein, means +/- SD, N = 5) and NTE (average of 13.8 nmol/min/mg protein) from untreated chick embryo brains.
The low inhibitions of NTE of compounds that were not neurotoxic (parathion, Diazinon) did not increase in the presence of NADPH; inhibitions of NTE of compounds that required activation (leptophos, S,S,S-tri-n-butyl phosphorotrithioate, and tri-o-cresyl phosphate) greatly increased with NADPH.
1(0,0,0,1) Details
1602578 Kendall RJ, Brewer LW, Hitchcock RR, Mayer JR: American wigeon mortality associated with turf application of diazinon AG500. J Wildl Dis. 1992 Apr;28(2):263-7.

The brains of all 85 wigeon were analyzed for acetylcholinesterase (AChE) activity.
1(0,0,0,1) Details
599594 Spyker JM, Avery DL: Neurobehavioral effects of prenatal exposure to the organophosphate Diazinon in mice. J Toxicol Environ Health. 1977 Dec;3(5-6):989-1002.

Brains obtained after sacrifice at 101 days of age revealed neuropathology in the forebrains of offspring born of mothers exposed to the higher dose.
1(0,0,0,1) Details