| Name | chloride channel (protein family or complex) |
|---|---|
| Synonyms | chloride channel |
| Name | lindane |
|---|---|
| CAS | (1α,2α,3β,4α,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8169820 | Nagata K, Narahashi T: Dual action of the cyclodiene insecticide dieldrin on the gamma-aminobutyric acid receptor-chloride channel complex of rat dorsal root ganglion neurons. J Pharmacol Exp Ther. 1994 Apr;269(1):164-71. The gamma-aminobutyric acidA (GABAA) receptor-chloride channel complex is known to be the target site of dieldrin, a cyclodiene insecticide, and lindane. |
82(1,1,1,2) | Details |
| 7679302 | Casida JE: Insecticide action at the -gated chloride channel: recognition, progress, and prospects. Arch Insect Biochem Physiol. 1993;22(1-2):13-23. Three billion (3 x 10 (9)) pounds of hexachlorocyclohexanes, polychlorobornanes, and chlorinated cyclodienes (such as lindane, toxaphene, and endosulfan, respectively) were used to control pest insects before their mode of action was established as blocking the -gated chloride channel. |
82(1,1,1,2) | Details |
| 12645305 | Sauviat MP, Pages N: [Cardiotoxicity of lindane, a gamma isomer of hexachlorocyclohexane] . J Soc Biol. 2002;196(4):339-48. Lindane exerts a stimulating action on synaptic transmission and inhibits the current activated by gamma-amino of many muscular and nervous preparations by interacting with the receptors -chloride channel complex. |
81(1,1,1,1) | Details |
| 8841090 | Narahashi T: Neuronal ion channels as the target sites of insecticides. Pharmacol Toxicol. 1996 Jul;79(1):1-14. The insecticide-channel interactions that have been studied most extensively are pyrethroid actions on the voltage-gated sodium channel and cyclodiene/lindane actions on the GABAA receptor chloride channel complex. |
81(1,1,1,1) | Details |
| 7682602 | Sola C, Martinez E, Camon L, Pazos A, Rodriguez-Farre E: Lindane administration to the rat induces modifications in the regional cerebral binding of [3H] Muscimol, [3H]-flunitrazepam, and t-[35S] butylbicyclophosphorothionate: an autoradiographic study. J Neurochem. 1993 May;60(5):1821-34. The observed decrease in [35S] TBPS binding is in agreement with the postulated action of lindane at the picrotoxinin binding site of the GABAA receptor chloride channel. |
81(1,1,1,1) | Details |
| 7566682 | Joy RM, Walby WF, Stark LG, Albertson TE: Lindane blocks GABAA-mediated inhibition and modulates pyramidal cell excitability in the rat hippocampal slice. Neurotoxicology. 1995 Summer;16(2):217-28. Lindane (50 microM) also completely reversed the effects of the injectable anesthetic, propofol, a compound known to potentiate GABAA-mediated inhibition via a direct action on the GABAA receptor-chloride channel complex. |
81(1,1,1,1) | Details |
| 1380684 | Rivera S, Sanfeliu C, Garcia M, Comellas F, Rodriguez-Farre E: Increase in rat pup ultrasonic isolation calls induced by lindane. . Neurotoxicology. 1992 Spring;13(1):235-9. It is suggested that lindane has an anxiogenic effect mediated through its action on the benzodiazepine-GABAA receptor-chloride channel complex. |
81(1,1,1,1) | Details |
| 18651916 | Hirata K, Ishida C, Eguchi Y, Sakai K, Ozoe F, Ozoe Y, Matsuda K: Role of a serine residue (S278) in the pore-facing region of the housefly -gated chloride channel in determining sensitivity to noncompetitive antagonists. Insect Mol Biol. 2008 Aug;17(4):341-50. |
1(0,0,0,1) | Details |
| 16537435 | Chen L, Durkin KA, Casida JE: Structural model for gamma-aminobutyric acid receptor noncompetitive antagonist binding: widely diverse structures fit the same site. Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5185-90. Epub 2006 Mar 10. Several major insecticides, including alpha-endosulfan, lindane, and fipronil, and the botanical picrotoxinin are noncompetitive antagonists (NCAs) for the GABA receptor. Despite large structural diversity, the NCAs are proposed to fit a single binding site in the chloride channel lumen lined by five transmembrane 2 segments. |
1(0,0,0,1) | Details |
| 12770368 | Aydar E, Beadle DJ: The pharmacological profile of GABA receptors on cultured insect neurones. J Insect Physiol. 1999 Mar;45(3):213-219. The results indicated that insect GABA receptors are linked to a chloride channel that can be activated by both (A) and (C) receptor agonists. The receptors were modulated by the enantiomers of lindane. |
1(0,0,0,1) | Details |
| 9860498 | Hainzl D, Cole LM, Casida JE: Mechanisms for selective toxicity of fipronil insecticide and its sulfone metabolite and desulfinyl photoproduct. Chem Res Toxicol. 1998 Dec;11(12):1529-35. Fipronil, an N-phenylpyrazole with a trifluoromethylsulfinyl substituent, initiated the second generation of insecticides acting at the (GABA) receptor to block the chloride channel. The first generation includes the polychlorocycloalkanes alpha-endosulfan and lindane. |
1(0,0,0,1) | Details |
| 1663556 | Payne GT, Soderlund DM: Activation of insensitive channels in mouse brain synaptic vesicles by avermectin B1a. J Biochem Toxicol. 1991 Winter;6(4):283-92. However, the chlorinated cycloalkane insecticides dieldrin and lindane were equally effective as inhibitors of -dependent uptake and AVMB1a-stimulated efflux. |
0(0,0,0,0) | Details |
| 7534833 | Pomes A, Frandsen A, Sunol C, Sanfeliu C, Rodriguez-Farre E, Schousboe A: Lindane cytotoxicity in cultured neocortical neurons is ameliorated by and flunitrazepam. J Neurosci Res. 1994 Dec 15;39(6):663-8. An interaction with the GABA receptor-gated chloride channel was demonstrated by an inhibitory action of lindane on [35S] TBPS binding (IC50 188 +/- 51 nM) and on -stimulated 36Cl- influx in the neurons. |
81(1,1,1,1) | Details |
| 1722072 | Narahashi T: Transmitter-activated ion channels as the target of chemical agents. Adv Exp Med Biol. 1991;287:61-73. The -activated chloride channel has been shown to be modulated by general anesthetics, and the pyrethroid, cyclodiene and lindane insecticides. |
31(0,1,1,1) | Details |
| 14635176 | Bloomquist JR: channels as tools for developing selective insecticides. Arch Insect Biochem Physiol. 2003 Dec;54(4):145-56. The (1)) receptor/ ionophore complex is the primary site of action for a number of currently used insecticides, such as lindane, endosulfan, and fipronil. These compounds act as antagonists by stabilizing nonconducting conformations of the chloride channel. |
5(0,0,0,5) | Details |
| 1375788 | Bloomquist JR: Intrinsic lethality of chloride-channel-directed insecticides and convulsants in mammals. Toxicol Lett. 1992 May;60(3):289-98. In contrast, the toxicities of lindane, abamectin, and the bicyclic convulsants TBPS and a TBOB analog were approximately the same by either route of administration. |
3(0,0,0,3) | Details |
| 8054658 | Bloomquist JR: Cyclodiene resistance at the insect GABA receptor/chloride channel complex confers broad cross resistance to convulsants and experimental phenylpyrazole insecticides. Arch Insect Biochem Physiol. 1994;26(1):69-79. The Maryland strain of D. melanogaster was resistant to dieldrin, lindane, picrotoxinin, TBPS, p-CN-TBOB, and JKU 0422. |
3(0,0,0,3) | Details |
| 8750965 | Nagata K, Narahashi T: Differential effects of hexachlorocyclohexane isomers on the GABA receptor-chloride channel complex in rat dorsal root ganglion neurons. Brain Res. 1995 Dec 15;704(1):85-91. |
3(0,0,0,3) | Details |
| 7885191 | Cole LM, Roush RT, Casida JE: Drosophila -gated chloride channel: modified [3H] EBOB binding site associated with --> Ser or Gly mutants of Rdl subunit. Life Sci. 1995;56(10):757-65. This specific binding of [3H] EBOB is strongly inhibited by: a large number and variety of insecticidal channel blockers at 20 nM (lindane, alpha-endosulfan, dieldrin, 12-ketoendrin, fipronil, and a representative bicycloorthobenzoate and dithiane) or 200 nM (picrotoxinin); the insecticidal channel activators avermectin and moxidectin at 20 nM; muscimol at 30 microM and GABA at 300 microM. |
2(0,0,0,2) | Details |
| 17201770 | Eguchi Y, Ihara M, Ochi E, Shibata Y, Matsuda K, Fushiki S, Sugama H, Hamasaki Y, Niwa H, Wada M, Ozoe F, Ozoe Y: Functional characterization of Musca - and -gated channels expressed independently and coexpressed in Xenopus oocytes. Insect Mol Biol. 2006 Dec;15(6):773-83. Genes encoding subunits of two LGICs, -gated chloride channel (MdGluCl-alpha) and a -gated chloride channel (MdRdl), were cloned from house-flies (Musca domestica L.). |
2(0,0,0,2) | Details |
| 11879973 | Ratra GS, Erkkila BE, Weiss DS, Casida JE: Unique insecticide specificity of human homomeric rho 1 (C) receptor. . Toxicol Lett. 2002 Mar 24;129(1-2):47-53. Several convulsants and major insecticides block the -gated chloride channel in brain on binding to the (A) receptor. This (C) rho 1 receptor is very sensitive to CNBOB and lindane relative to alpha-endosulfan, tert-butylbicyclophosphorothionate, picrotoxinin and fipronil (IC (50) values of 23, 91, 800, 1080, 4000 and > 10000 nM, respectively, in displacing [3H] EBOB). |
2(0,0,0,2) | Details |
| 11312652 | Ratra GS, Kamita SG, Casida JE: Role of human (A) receptor beta3 subunit in insecticide toxicity. Toxicol Appl Pharmacol. 2001 May 1;172(3):233-40. The type A (A)) receptor is the target for the major insecticides alpha-endosulfan, lindane, and fipronil and for many analogs. Their action as chloride channel blockers is directly measured by binding studies with [(3) H] ethynylbicycloorthobenzoate ([(3) H] EBOB). |
1(0,0,0,1) | Details |
| 8949935 | Nagata K, Huang CS, Hamilton BJ, Carter DB, Narahashi T: Differential effects of hexachlorocyclohexane isomers on the GABA receptor subunits expressed in human embryonic kidney cell line. Brain Res. 1996 Oct 28;738(1):131-7. We have recently demonstrated by patch clamp experiments that the four isomers of hexachlorocyclohexane (HCH), alpha-, beta-, gamma- and delta-HCH insecticides, modulated the kinetics of the GABAA receptor-chloride channel complex of rat dorsal root ganglion neurons. |
1(0,0,0,1) | Details |
| 8980028 | Lees G, Calder J: Interaction of Lindane Isomers with Currents in Insect Membranes: Steric Requirements for Channel Modulation and Block. Pestic Biochem Physiol. 1996 May;55(1):40-8. Liganding mechanisms and comparative/species differences in chloride channel pharmacology are discussed in the context of potential for development of invertebrate-selective pesticides. |
1(0,0,0,1) | Details |
| 1280523 | Tusell JM, Vendrell M, Serratosa J, Trullas R: Lindane-induced convulsions in NMRI and OF1 mice: antagonism with (+) MK-801 and voltage-dependent calcium channel blockers. Brain Res. 1992 Oct 16;593(2):209-14. Thus, a specific -gated chloride channel blocker, PTX, a GABAA receptor antagonist, PTZ, and an excitatory amino acid receptor agonist, were used. |
1(0,0,0,1) | Details |