| Name | Ah receptor |
|---|---|
| Synonyms | AHR; Ah receptor; AhR; Aryl hydrocarbon receptor; Aryl hydrocarbon receptor precursor; Dioxin receptor; Ah receptors; AhRs… |
| Name | vinclozolin |
|---|---|
| CAS | 3-(3,5-dichlorophenyl)-5-ethenyl-5-methyl-2,4-oxazolidinedione |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11392371 | Gray LE, Ostby J, Furr J, Wolf CJ, Lambright C, Parks L, Veeramachaneni DN, Wilson V, Price M, Hotchkiss A, Orlando E, Guillette L: Effects of environmental antiandrogens on reproductive development in experimental animals. Hum Reprod Update. 2001 May-Jun;7(3):248-64. Prenatal administration of a single low dose of dioxin (50-1,000 ng TCDD/kg) alters the differentiation of androgen-dependent tissues at p.p.t. concentrations, but the mechanism of action likely involves interaction with a hormone-like nuclear transcription factor, the hormone-like receptor AhR, rather than AR. p,p'-DDT and p,p'-DDE, vinclozolin and di-n-butyl affect reproductive function in rabbits when administered during prenatal and/or neonatal life. |
31(0,1,1,1) | Details |
| 10022274 | Gray LE Jr: Xenoendocrine disrupters: laboratory studies on male reproductive effects. Toxicol Lett. 1998 Dec 28;102-103:331-5. We have identified several pesticides (vinclozolin, procymidone, p,p'-DDE) which bind rat and human androgen receptors, block androgen-induced gene expression in vitro and in vivo, delay puberty, reduce sex accessory gland size and alter sex differentiation in the male rat. Prenatal administration of an Ah receptor agonist (2,3,7,8-TCDD or PCB 169) produces a different spectrum of effects including reduced ejaculated sperm numbers in male rats. |
1(0,0,0,1) | Details |