| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | vinclozolin |
|---|---|
| CAS | 3-(3,5-dichlorophenyl)-5-ethenyl-5-methyl-2,4-oxazolidinedione |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15651921 | Dierickx PJ: Cytotoxicity of the dicarboximide fungicides, vinclozolin and iprodione, in rat hepatoma-derived Fa32 cells. Altern Lab Anim. 2004 Oct;32(4):369-73. A -related cytochrome P450-dependent metabolic attack of vinclozolin and iprodione could be responsible for their cytotoxicity in Fa32 cells. |
112(1,2,2,2) | Details |
| 17686559 | Canistro D, Pozzetti L, Sapone A, Broccoli M, Affatato AA, Stradiotti A, Longo V, Menichini P, Barale R, Paolini M: Perturbation of murine liver cyp-superfamily of isoforms by different combinations of pesticide mixtures. Food Chem Toxicol. 2008 Jan;46(1):34-42. Epub 2007 Jun 28. It was previously found that fenarimol, vinclozolin or acephate, three of the most used pesticides worldwide, provoked a marked perturbation of murine cytochrome P450 (CYP)-linked monooxygenases. |
31(0,1,1,1) | Details |
| 8921505 | Hrelia P, Fimognari C, Maffei F, Vigagni F, Mesirca R, Pozzetti L, Paolini M, Cantelli Forti G: The genetic and non-genetic toxicity of the fungicide Vinclozolin. . Mutagenesis. 1996 Sep;11(5):445-53. Several cytochrome P450 (CYP)-dependent reactions have been monitored in liver, kidney and lung microsomes of male and female Swiss Albino CD1 mice in order to ascertain certain toxic non-genetic properties (related to carcinogenesis) of Vinclozolin. |
6(0,0,1,1) | Details |
| 7986207 | Ronis MJ, Ingelman-Sundberg M, Badger TM: Induction, suppression and inhibition of multiple hepatic cytochrome P450 isozymes in the male rat and bobwhite quail (Colinus virginianus) by biosynthesis inhibiting fungicides (EBIFs). Biochem Pharmacol. 1994 Nov 16;48(10):1953-65. In the current study, we examined the effects of two EBIFs in clinical use, and ketoconazole, and two agricultural EBIFs, propiconazole and vinclozolin, on hepatic monooxygenase activities and P450 apoprotein expression in the male Sprague-Dawley rat and the male bobwhite quail. |
3(0,0,0,3) | Details |
| 9972464 | Ronis MJ, Celander M, Badger TM: Cytochrome P450 enzymes in the kidney of the bobwhite quail (Colinus virginianus): induction and inhibition by biosynthesis inhibiting fungicides. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1998 Nov;121(1-3):221-9. The effects of treatment with the fungicides: propiconazole, vinclozolin, and ketoconazole were examined. |
3(0,0,0,3) | Details |
| 7871535 | Ronis MJ, Badger TM: Toxic interactions between fungicides that inhibit biosynthesis and phosphorothioate insecticides in the male rat and bobwhite quail (Colinus virginianus). Toxicol Appl Pharmacol. 1995 Feb;130(2):221-8. Male Sprague-Dawley rats (300 g) were administered corn oil or the following EBIFs: propiconazole (400 mg/kg/day), vinclozolin (400 mg/kg/day), (100 mg/kg/day), or ketoconazole (100 mg/kg/day) for 3 days by oral gavage. Induction of cytochrome P450 in rat and quail liver by EBIFs was accompanied by enhanced oxidative desulfuration of malathion, parathion, and diazinon to toxic oxon products. |
1(0,0,0,1) | Details |
| 14967917 | Kubota K, Ohsako S, Kurosawa S, Takeda K, Qing W, Sakaue M, Kawakami T, Ishimura R, Tohyama C: Effects of vinclozolin administration on sperm production and biosynthetic pathway in adult male rat. J Reprod Dev. 2003 Oct;49(5):403-12. |
0(0,0,0,0) | Details |