| Name | demethylase |
|---|---|
| Synonyms | DMTase; Demethylase; MBD 2; MBD2; Methyl CpG binding domain protein 2; Methyl CpG binding protein MBD2; NY CO 41; Demethylases… |
| Name | vinclozolin |
|---|---|
| CAS | 3-(3,5-dichlorophenyl)-5-ethenyl-5-methyl-2,4-oxazolidinedione |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7986207 | Ronis MJ, Ingelman-Sundberg M, Badger TM: Induction, suppression and inhibition of multiple hepatic cytochrome P450 isozymes in the male rat and bobwhite quail (Colinus virginianus) by biosynthesis inhibiting fungicides (EBIFs). Biochem Pharmacol. 1994 Nov 16;48(10):1953-65. In the current study, we examined the effects of two EBIFs in clinical use, and ketoconazole, and two agricultural EBIFs, propiconazole and vinclozolin, on hepatic monooxygenase activities and P450 apoprotein expression in the male Sprague-Dawley rat and the male bobwhite quail. EBIFs produced Type II binding spectra with hepatic microsomes from both species and were effective inhibitors of methoxyresorufin O-demethylase, an activity selective for P450 isozymes in gene family 1. |
1(0,0,0,1) | Details |
| 7722883 | Lodovici M, Aiolli S, Monserrat C, Dolara P, Medica A, Di Simplicio P: Effect of a mixture of 15 commonly used pesticides on DNA levels of and xenobiotic metabolizing enzymes in rat liver. J Environ Pathol Toxicol Oncol. 1994;13(3):163-8. The level of 8-OH- in rat liver DNA was measured as an index of oxidative damage after treating rats for 10 days at a dose ranging from 0.75 to 10 mg/kg with a mixture of 15 pesticides (dithiocarbamate, benomyl, thiabendazole, diphenylamine, chlorthalonil, procimidone, methidathion, chlorpyrifos-ethyl, fenarimol, parathion-methyl, chlorpropham, parathion, vinclozolin, chlorfenvinphos, pirimiphos-ethyl) commonly found in foods of central Italy. The administration of the pesticide mixture dose dependently reduced benzo (a) pyrene hydroxylase, N-demethylase activities, peroxidase, glutathione reductase, glutathione-S-transferase and thiol transferase activities in the liver. |
1(0,0,0,1) | Details |