Protein Information

Name casein
Synonyms Alpha; Alpha s1 casein; Alpha s1 casein precursor; CASA; CSN 1; CSN1; CSN1S1; Casein…

Compound Information

Name potassium thiocyanate
CAS potassium thiocyanate

Reference List

PubMed Abstract RScore(About this table)
490674 Philbrick DJ, Hopkins JB, Hill DC, Alexander JC, Thomson RG: Effects of prolonged cyanide and thiocyanate feeding in rats. J Toxicol Environ Health. 1979 Jul;5(4):579-92.

Male weaning rats were fed a semipurified diet containing 10% casein; this diet restricted in methionine, vitamin B12, and iodine; or the complete and restricted diets supplemented with either 1500 ppm potassium cyanide or 2240 ppm potassium thiocyanate for 11.5 mo.
6(0,0,1,1) Details
510280 Shikimi T, Kobayashi T, Hattori K: Modes of inhibition of activities of trypsin and chymotrypsin by potassium thiocyanate. Enzyme. 1979;24(5):348-52.

The inhibition was mixed type on both enzymes with casein as substrate and on trypsin with tosyl-L-arginine methyl ester as substrate, but was uncompetitive on chymotrypsin with benzoyl-L-tyrosine p-nitroanilide as substrate.
1(0,0,0,1) Details
12034886 Akiyama Y: Proton-motive force stimulates the proteolytic activity of FtsH, a membrane-bound ATP-dependent protease in Escherichia coli. Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8066-71. Epub 2002 May 28.

In vitro casein degradation by membrane-integrated FtsH was stimulated by succinate, a respiratory substrate; this stimulation was counteracted by cyanide-3-chlorophenylhydrazone.
Potassium thiocyanate, which specifically collapses Deltapsi, partially canceled the effect of succinate, but ammonium sulfate, which collapses DeltapH, showed little effect.
1(0,0,0,1) Details