Protein Information

Name prion protein
Synonyms ASCR; PRIP; PRP; PRNP; Prion related protein; CD230; CD230 antigen; CJD…

Compound Information

Name sodium azide
CAS sodium azide

Reference List

PubMed Abstract RScore(About this table)
16784193 Kirchmayr R, Reichl HE, Schildorfer H, Braun R, Somerville RA: Prion protein: detection in 'spiked' anaerobic sludge and degradation experiments under anaerobic conditions. Water Sci Technol. 2006;53(8):91-8.

In comparison, with sterilized (121 degrees C, steam pressure) or poisoned (sodium azide, 1% w/v) sludge used as incubation matrix a much shorter time resulted until no prion protein could be detected.
3(0,0,0,3) Details
11243411 Bailleul-Winslett PA, Newnam GP, Wegrzyn RD, Chernoff YO: An antiprion effect of the anticytoskeletal drug latrunculin A in yeast. Gene Expr. 2000;9(3):145-56.

In vitro, prion proteins form amyloid fibers, resembling cytoskeletal structures.
On the other hand, treatments with sodium azide or cycloheximide, agents blocking yeast protein synthesis and cell proliferation but not disrupting the cytoskeleton, do not cause a significant loss of [PSI].
1(0,0,0,1) Details