| Name | CYP1A2 |
|---|---|
| Synonyms | CP12; CYP1A2; CYPIA 2; CYPIA2; Cytochrome P450 1A2; Dioxin inducible P3 450; P(3)450; P3 450… |
| Name | sodium azide |
|---|---|
| CAS | sodium azide |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11236840 | Salmela KS, Tsyrlov IB, Lieber CS: Azide inhibits human cytochrome P -4502E1, 1A2, and 3A4. Alcohol Clin Exp Res. 2001 Feb;25(2):253-60. METHODS AND RESULTS: Concentrations of sodium azide as low as 0.1 mM markedly inhibited the specific oxidation (mean +/- SEM) by recombinant CYP1A2 and CYP3A4 expressed in HepG2 cells (to 16 +/- 1% and 22 +/- 2% of control without azide, respectively; p < 0.01). |
167(2,2,2,7) | Details |
| 9918136 | Williams JA, Stone EM, Millar BC, Gusterson BA, Grover PL, Phillips DH: Determination of the enzymes responsible for activation of the heterocyclic amine 2-amino-3-methylimidazo [4,5-f] quinoline in the human breast. Pharmacogenetics. 1998 Dec;8(6):519-28. In man, hepatic activation is carried out by cytochrome P450 (CYP) 1A2 and the ultimate DNA-reactive species is thought to be a nitrenium ion formed via an acetoxy ester of an exocyclic amino group. Adduct formation in stimulated neutrophils was inhibited 80% by the myeloperoxidase inhibitor sodium azide (1 mM) but was not affected by proadifen (100 microM), indomethacin (100 microM), or eicosatetraynoic acid (100 microM), inhibitors of cytochrome P450, prostaglandin synthetase, and lipoxygenase, respectively. |
1(0,0,0,1) | Details |