| Name | p38 |
|---|---|
| Synonyms | AIMP 2; p38; AIMP2; JTV 1; JTV1; JTV1 gene; JTV1 protein; Multisynthetase complex auxiliary component p38… |
| Name | sodium azide |
|---|---|
| CAS | sodium azide |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12945585 | Le Panse R, Dubertret L, Coulomb B: p38 mitogen-activated protein kinase activation by ultraviolet A radiation in human dermal fibroblasts. Photochem Photobiol. 2003 Aug;78(2):168-74. and sodium azide had an inhibitory effect on UVA activation of p38 MAPK, pointing to a role of singlet in transduction of the UVA effect. |
85(1,1,1,5) | Details |
| 11375893 | Buchczyk DP, Klotz LO, Lang K, Fritsch C, Sies H: High efficiency of -photodynamic treatment using UVA irradiation. Carcinogenesis. 2001 Jun;22(6):879-83. ALA-PDT using red light (550-750 nm) is known to lead to the activation of stress kinases, such as c-Jun-N-terminal kinase and p38. |
2(0,0,0,2) | Details |
| 16571865 | Li Z, Hyseni X, Carter JD, Soukup JM, Dailey LA, Huang YC: Pollutant particles enhanced H2O2 production from NAD (P) H oxidase and mitochondria in human pulmonary artery endothelial cells. Am J Physiol Cell Physiol. 2006 Aug;291(2):C357-65. Epub 2006 Mar 29. We measured the production of extracellular H2O2, activation of extracellular signal-regulated kinases1/2 (ERK1/2) and p38 MAPKs in human pulmonary artery endothelial cells (HPAEC) treated with urban particles (UP; SRM1648), and assessed the effects of H2O2 on vasoconstriction in pulmonary artery ring and isolated perfused lung. Within minutes after UP treatment, HPAEC increased H2O2 production that could be inhibited by diphenyleneiodonium (DPI), apocynin (APO), and sodium azide (NaN3). |
2(0,0,0,2) | Details |
| 20032508 | Endale M, Kim SD, Lee WM, Kim S, Suk K, Cho JY, Park HJ, Wagley Y, Kim S, Oh JW, Rhee MH: Ischemia induces regulator of G protein signaling 2 (RGS2) protein upregulation and enhances apoptosis in astrocytes. Am J Physiol Cell Physiol. 2010 Mar;298(3):C611-23. Epub 2009 Dec 23. Upregulated RGS2 was significantly inhibited by SB-203580, a p38 MAPK inhibitor. A marked increase in RGS2 occurred after ischemic stress induced by chemicals (sodium azide and 2-deoxyglucose) or - deprivation (OGD, real ischemia). |
2(0,0,0,2) | Details |
| 19191104 | Kikuchi K, Kohyama T, Yamauchi Y, Kato J, Takami K, Okazaki H, Desaki M, Nagase T, Rennard SI, Takizawa H: C-reactive protein modulates human lung fibroblast migration. Exp Lung Res. 2009 Feb;35(1):48-58. Western blot analysis showed that CRP inhibited the p38 mitogen-activated protein kinase (MAPK) activity in the presence of HFn. |
2(0,0,0,2) | Details |
| 15064160 | Okai Y, Sato EF, Higashi-Okai K, Inoue M: Enhancing effect of the endocrine disruptor para-nonylphenol on the generation of reactive species in human blood neutrophils. Environ Health Perspect. 2004 Apr;112(5):553-6. -dependent oxidase inhibitor, diphenyl iodonium and the myeloperoxidase inhibitor sodium azide (NaN3) showed remarkable inhibitory effects on ROS generation induced by NP, but an inhibitor against mitochondrial respiratory function, (KCN), did not exhibit significant effect. The selective protein kinase C inhibitor Ro-32-0432, p38 MAP kinase inhibitor SB 203580, and ERK MAP kinase inhibitor PD 98059 also showed significant suppressive effects on NP-induced ROS generation. |
1(0,0,0,1) | Details |
| 18563357 | Han M, Im DS: Effects of mitochondrial inhibitors on cell viability in U937 monocytes under deprivation. Arch Pharm Res. 2008 Jun;31(6):749-57. Epub 2008 Jun 19. Mitochondrial inhibitors such as rotenone, TTFA, antimycin A, sodium azide, oligomycin, and valinomycin were used in this study. Activities of Akt and p38 MAPK, however, were decreased by the inhibitors under deprivation condition except TTFA. |
1(0,0,0,1) | Details |
| 17384288 | Siniscalchi A, Cavallini S, Marino S, Falzarano S, Franceschetti L, Selvatici R: Effects of chemical ischemia on cerebral cortex slices: focus on mitogen-activated protein kinase cascade. Ann N Y Acad Sci. 2006 Dec;1090:445-54. In superfused, electrically stimulated rat cerebral cortex slices, chemical ischemia (CI) was induced by a 5-min treatment with the mitochondrial toxin, sodium azide (10 mM), combined with the glycolysis blocker, 2-deoxyglucose (2 mM). Western blot analysis of p21Ras, extracellular signal-regulated protein kinases (ERK) 1/2 (p44/42), phospho-ERK1/2, mitogen-activated protein kinase (MAPK)-p38, phospho-p38, stress-activated protein kinases/c-Jun NH2-terminal protein kinases (SAPK/JNK), phospho-SAPK/JNK was carried out. |
1(0,0,0,1) | Details |
| 16621957 | Ossum CG, Wulff T, Hoffmann EK: Regulation of the mitogen-activated protein kinase p44 ERK activity during anoxia/recovery in rainbow trout hypodermal fibroblasts. J Exp Biol. 2006 May;209(Pt 9):1765-76. Here we characterise a p44ERK-like protein in the rainbow trout cell line RTHDF and study the effect of (i) serum stimulation, (ii) sodium azide (chemical anoxia) and removal of azide (recovery) and (iii) anoxia (P (O) 2 <0.1%) and recovery. The inhibition was secondary to activation of p38 (MAPK) and the increase was MEK dependent, as SB203580 inhibited the dephosphorylation during anoxia and the presence of PD98059 inhibited phosphorylation of p44ERK during recovery. |
1(0,0,0,1) | Details |
| 17900002 | Okai Y, Sato EF, Higashi-Okai K, Inoue M: Potentiating effect of an endocrine disruptor, paranonylphenol, on the generation of reactive species (ROS) in human venous blood -- association with the activation of signal transduction pathway. J UOEH. 2007 Sep 1;29(3):221-33. An -dependent oxidase inhibitor, diphenyl iodonium (DPI), and a myeloperoxidase inhibitor, sodium azide (NaN3), showed remarkable inhibitory effects on ROS generation induced by NP, but an inhibitor against mitochondrial respiratory function, (KCN), did not exhibit a significant effect. Selective protein kinase C inhibitor, Ro-32-0432, p38 MAP kinase inhibitor, SB-203580, and ERK MAP kinase inhibitor, PD 98059, showed significant suppressive effects on NP-induced ROS generation. |
1(0,0,0,1) | Details |