| Name | p38 |
|---|---|
| Synonyms | AIMP 2; p38; AIMP2; JTV 1; JTV1; JTV1 gene; JTV1 protein; Multisynthetase complex auxiliary component p38… |
| Name | mercuric chloride |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11312036 | Son MH, Kang KW, Lee CH, Kim SG: Potentiation of arsenic-induced cytotoxicity by amino acid deprivation (SAAD) through activation of ERK1/2, p38 kinase and JNK1: the distinct role of JNK1 in SAAD-potentiated mercury toxicity. Toxicol Lett. 2001 Apr 8;121(1):45-55. Viability was assessed in H4IIE cells treated with arsenite, mercuric chloride, selenite, lead trioxide or |
3(0,0,0,3) | Details |
| 15050407 | Kim SH, Sharma RP: Mercury-induced apoptosis and necrosis in murine macrophages: role of -induced reactive species and p38 mitogen-activated protein kinase signaling. Toxicol Appl Pharmacol. 2004 Apr 1;196(1):47-57. The cytotoxic EC (50) of mercury ranged from 62.7 to 81.1 microM by various assays in J774A.1 cultures; accordingly, we employed 70 microM of mercuric chloride in most experiments. |
6(0,0,0,6) | Details |
| 15649634 | Barnes DM, Kircher EA: Effects of mercuric chloride on transport in 3T3-L1 adipocytes. . Toxicol In Vitro. 2005 Mar;19(2):207-14. Phosphorylation of p38 kinase and c-Jun N-terminal kinase (JNK) were examined as possible mediators of mercury induced GLUT 1 levels. |
2(0,0,0,2) | Details |
| 16997801 | Choi CH, Bark H, Chung JM, Park EK, Kim SH: Elevated reactive species but not regulate mercury resistance to AML-2/DX100 cells. Immunopharmacol Immunotoxicol. 2006;28(3):545-55. This study was designed to investigate the role of reactive species (ROS) and on the resistance of AML-2/DX100 cells to mercuric chloride. The specific inhibitor for p38 MAPK and ERK, and antioxidant decreased the production of MRP1 and therefore resistance of AML-2/DX100 cells against mercury exposure. |
2(0,0,0,2) | Details |
| 11104828 | Matsuoka M, Wispriyono B, Iryo Y, Igisu H, Sugiura T: Inhibition of HgCl2-induced mitogen-activated protein kinase activation by LL-Z1640-2 in CCRF-CEM cells. Eur J Pharmacol. 2000 Dec 8;409(2):155-8. Exposure of HgCl2 to CCRF-CEM human lymphoblastoid cells induced phosphorylation of mitogen-activated protein kinases (MAPKs); extracellular signal-regulated protein kinase (ERK), c-Jun N-terminal kinase (JNK) and p38. |
2(0,0,0,2) | Details |
| 10544060 | Turney KD, Parrish AR, Orozco J, Gandolfi AJ: Selective activation in the MAPK pathway by Hg (II) in precision-cut rabbit renal cortical slices. Toxicol Appl Pharmacol. 1999 Nov 1;160(3):262-70. Cortical slices (275 microm) were obtained from 1.0 kg NZW rabbits and exposed to mercuric chloride [Hg (II)] at concentrations of 0.01-10 microM for 2-8 h. |
0(0,0,0,0) | Details |
| 15226156 | Jia Z, Person MD, Dong J, Shen J, Hensley SC, Stevens JL, Monks TJ, Lau SS: Grp78 is essential for 11-deoxy-16,16-dimethyl -mediated cytoprotection in renal epithelial cells. Am J Physiol Renal Physiol. 2004 Dec;287(6):F1113-22. Epub 2004 Jun 29. We have now determined the ability of DDM-PGE (2) to protect against other renal toxicants and report that DDM-PGE (2) only protects against oncotic cell death, induced by H (2) O (2), iodoacetamide, and TGHQ, but not against apoptotic cell death induced by cisplatin, mercuric chloride, or tumor necrosis factor-alpha. Moreover, TGHQ-induced p38 MAPK activation is disrupted under conditions of a compromised ER stress response in pkASgrp78 cells, which likely contributes to the loss of cytoprotection. |
1(0,0,0,1) | Details |