Protein Information

Name Bcl xL
Synonyms Apoptosis regulator Bcl X; BCL XL/S; BCL2 like 1; BCL2 related gene; BCL2 like 1 isoform 1; BCL2L; BCL2L1; BCLX…

Compound Information

Name maneb
CAS

Reference List

PubMed Abstract RScore(About this table)
15824117 Thiruchelvam M, Prokopenko O, Cory-Slechta DA, Buckley B, Mirochnitchenko O: Overexpression of superoxide dismutase or glutathione peroxidase protects against the paraquat + maneb-induced Parkinson disease phenotype. J Biol Chem. 2005 Jun 10;280(23):22530-9. Epub 2005 Apr 11.

Even a single injection of paraquat + maneb in the non-transgenic treated group modulated several key pro- and anti-apoptotic proteins, including Bax, Bad, Bcl-xL, and upstream stress-induced cascade.
81(1,1,1,1) Details
18266926 Fei Q, Ethell DW: Maneb potentiates paraquat neurotoxicity by inducing key Bcl-2 family members. J Neurochem. 2008 Mar 11.

Focusing on mechanisms responsible for this synergy, we found that maneb+PQ increased the expression of three strong Bak inhibitors, Bfl-1, Bcl-xL and Mcl-1, and also induced Bax activators that included Bik and Bim.
1(0,0,0,1) Details