| Name | alpha synuclein |
|---|---|
| Synonyms | Alpha synuclein; PARK4; PD1; NACP; Non A beta component of AD amyloid; Non A4 component of amyloid; Non A4 component of amyloid precursor; PARK 1… |
| Name | maneb |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17286743 | Ishido M: inhibits maneb-induced aggregation of alpha-synuclein in rat pheochromocytoma cells. J Pineal Res. 2007 Mar;42(2):125-30. Thus, prevents maneb-induced neurodegeneration at a nighttime physiological blood concentration, most likely by inhibiting the aggregation of alpha-synuclein as well as preventing mitochondrial dysfunction in PC 12 cells. |
149(1,3,4,4) | Details |
| 17255333 | Norris EH, Uryu K, Leight S, Giasson BI, Trojanowski JQ, Lee VM: Pesticide exposure exacerbates alpha-synucleinopathy in an A53T transgenic mouse model. Am J Pathol. 2007 Feb;170(2):658-66. In this study, A53T mutant human alpha-synuclein transgenic mice (M83), which develop alpha-synuclein neuropathology, were treated with the pesticides paraquat and maneb (either singly or together), and their effects were analyzed. |
8(0,0,1,3) | Details |
| 18715146 | Ethell DW, Fei Q: Parkinson-linked genes and toxins that affect neuronal cell death through the Bcl-2 family. Antioxid Redox Signal. 2009 Mar;11(3):529-40. Potential causative factors include environmental toxins and gene mutations that can combine to dysregulate the processing and degradation of alpha-synuclein. Oxidative stress induced by the neurotoxins MPTP, paraquat, maneb, and rotenone causes lipid peroxidation and protein misfolding that affects cell death through members of the Bcl-2 family. |
2(0,0,0,2) | Details |
| 15350641 | Zhou Y, Shie FS, Piccardo P, Montine TJ, Zhang J: Proteasomal inhibition induced by ethylene-bis-dithiocarbamate: relevance to Parkinson's disease. Neuroscience. 2004;128(2):281-91. Maneb, a widely used fungicide, has been associated with Parkinsonism in humans. Proteasomal dysfunction was accompanied by formation of cytoplasmic inclusions that were positive for alpha-synuclein immunostaining and significantly increased -insoluble alpha-synuclein aggregation seen by Western blot analysis. |
2(0,0,0,2) | Details |