| Name | caspase 3 |
|---|---|
| Synonyms | Apopain; CASP 3; CASP3; CPP 32; CPP32; CPP32B; Caspase 3; Caspase 3 precursor… |
| Name | biphenyl |
|---|---|
| CAS | 1,1′-biphenyl |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18507762 | Deng J, Qian Y, Geng L, Chen J, Wang X, Xie H, Yan S, Jiang G, Zhou L, Zheng S: Involvement of p38 mitogen-activated protein kinase pathway in honokiol-induced apoptosis in a human hepatoma cell line (hepG2). Liver Int. 2008 Dec;28(10):1458-64. Epub 2008 May 26. Western blots were used to analyse the expression of various proteins (procaspase-9, procaspase-3, cleaved caspase-3, cytochrome c, Bcl-2, Bax, Bad, Bcl-X (L) and p38). |
4(0,0,0,4) | Details |
| 18413764 | Huang S, Sinicrope FA: BH3 mimetic ABT-737 potentiates TRAIL-mediated apoptotic signaling by unsequestering Bim and Bak in human pancreatic cancer cells. Cancer Res. 2008 Apr 15;68(8):2944-51. ABT-737 was shown to enhance TRAIL-induced apoptosis as shown by DNA fragmentation, activation of caspase-8 and Bid, and cleavage of caspase-3 and poly (ADP- polymerase. |
3(0,0,0,3) | Details |
| 19010845 | Micha D, Cummings J, Shoemaker A, Elmore S, Foster K, Greaves M, Ward T, Rosenberg S, Dive C, Simpson K: Circulating biomarkers of cell death after treatment with the BH-3 mimetic ABT-737 in a preclinical model of small-cell lung cancer. Clin Cancer Res. 2008 Nov 15;14(22):7304-10. In parallel, tumors were interrogated for cleaved caspase-3 and cleaved cytokeratin 18 as biomarkers of apoptosis. |
3(0,0,0,3) | Details |
| 18440692 | Li Z, Liu Y, Zhao X, Pan X, Yin R, Huang C, Chen L, Wei Y: Honokiol, a natural therapeutic candidate, induces apoptosis and inhibits angiogenesis of ovarian tumor cells. Eur J Obstet Gynecol Reprod Biol. 2008 Sep;140(1):95-102. Epub 2008 Apr 28. Expression of Bcl-2 members and caspase-3 were assessed. |
2(0,0,0,2) | Details |
| 19022367 | Ndountse LT, Chan HM: Role of N-methyl-D-aspartate receptors in polychlorinated biphenyl mediated neurotoxicity. Toxicol Lett. 2009 Jan 10;184(1):50-5. Epub 2008 Oct 28. NMDAR was measured using a radiolabeled phencyclidine receptor ligand [(3) H]-MK801, apoptosis was quantified using fluorogenic substrates specific for caspase-3 (DEVD-AFC) and cell death using lactate dehydrogenase (LDH) release. |
2(0,0,0,2) | Details |
| 19773376 | Kim KW, Moretti L, Mitchell LR, Jung DK, Lu B: Combined Bcl-2/mammalian target of rapamycin inhibition leads to enhanced radiosensitization via induction of apoptosis and autophagy in non-small cell lung tumor xenograft model. Clin Cancer Res. 2009 Oct 1;15(19):6096-105. Epub 2009 Sep 22. ABT-737 induced cleaved caspase-3, a marker of apoptosis, and rapamycin correlated with an increase in punctate localization of green fluorescent protein-LC3, characteristic of autophagy. |
2(0,0,0,2) | Details |
| 19088028 | Okumura K, Huang S, Sinicrope FA: Induction of Noxa sensitizes human colorectal cancer cells expressing Mcl-1 to the small-molecule Bcl-2/Bcl-xL inhibitor, ABT-737. Clin Cancer Res. 2008 Dec 15;14(24):8132-42. Apoptosis induction by the drug combination was associated with enhanced caspase-8, caspase-9, and caspase-3 activation and poly (ADP- polymerase cleavage that were completely abrogated in Bax knockout cells. |
2(0,0,0,2) | Details |
| 19366808 | Kurosu T, Ohki M, Wu N, Kagechika H, Miura O: Sorafenib induces apoptosis specifically in cells expressing BCR/ABL by inhibiting its kinase activity to activate the intrinsic mitochondrial pathway. Cancer Res. 2009 May 1;69(9):3927-36. Epub 2009 Apr 14. It was further revealed that sorafenib activates Bax and caspase-3 and reduces mitochondrial membrane potential specifically in BCR/ABL-driven cells. |
1(0,0,0,1) | Details |
| 19135778 | Park EJ, Min HY, Chung HJ, Hong JY, Kang YJ, Hung TM, Youn UJ, Kim YS, Bae K, Kang SS, Lee SK: Down-regulation of c-Src/EGFR-mediated signaling activation is involved in the honokiol-induced cell cycle arrest and apoptosis in MDA-MB-231 human breast cancer cells. Cancer Lett. 2009 May 18;277(2):133-40. Epub 2009 Jan 9. Apoptosis caused by honokiol was also concomitant with the cleavage of caspases (caspase-3, -8, and -9) and Bid along with the suppressive expression of Bcl-2, but it was independent on the expression of Bax and p53. |
1(0,0,0,1) | Details |
| 18369342 | Yang JY, Della-Fera MA, Rayalam S, Baile CA: Enhanced effects of xanthohumol plus honokiol on apoptosis in 3T3-L1 adipocytes. Obesity (Silver Spring). 2008 Jun;16(6):1232-8. Epub 2008 Mar 27. Expression of apoptosis related proteins including cleaved poly (ADP- polymerase (PARP), cytochrome c, Bcl-2, caspase-3/7, phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and Akt was analyzed by western blotting. |
1(0,0,0,1) | Details |
| 18241858 | Lee SY, Yuk DY, Song HS, Yoon do Y, Jung JK, Moon DC, Lee BS, Hong JT: Growth inhibitory effects of obovatol through induction of apoptotic cell death in prostate and colon cancer by blocking of NF-kappaB. Eur J Pharmacol. 2008 Mar 17;582(1-3):17-25. Epub 2008 Jan 5. Correlated well with the induction of apoptosis, obovatol increased the expression of the apoptotic genes; Bax, caspase-3, caspase-9, whereas inhibited expression of anti-apoptotic genes; Bcl-2, inhibitor of apoptosis protein (IAP-1) and X chromosome IAP (XIAP) as well as the cell proliferation marker genes; Cox-2, c-Fos, c-Jun and cyclin D1. |
1(0,0,0,1) | Details |
| 19147759 | Ichite N, Chougule MB, Jackson T, Fulzele SV, Safe S, Singh M: Enhancement of docetaxel anticancer activity by a novel diindolylmethane compound in human non-small cell lung cancer. Clin Cancer Res. 2009 Jan 15;15(2):543-52. PURPOSE: This study was conducted to examine the cytotoxic effects of a peroxisome proliferator-activated receptor gamma (PPARgamma) agonist, 1,1-bis (3'-indolyl)-1-(p-biphenyl) (DIM-C-pPhC (6) H (5)), alone and in combination with docetaxel in vitro in A549 lung cancer cells and in vivo in nude mice bearing A549 orthotopic lung tumors. Apoptosis and cleaved caspase-3 expression in the harvested tissues were studied by terminal deoxynucleotidyl transferase-mediated nick end labeling and immunohistochemistry, respectively. |
1(0,0,0,1) | Details |
| 18095168 | Aparicio-Fernandez X, Reynoso-Camacho R, Castano-Tostado E, Garcia-Gasca T, Gonzalez de Mejia E, Guzman-Maldonado SH, Elizondo G, Yousef GG, Lila MA, Loarca-Pina G: Antiradical capacity and induction of apoptosis on HeLa cells by a Phaseolus vulgaris extract. Plant Foods Hum Nutr. 2008 Mar;63(1):35-40. Epub 2007 Dec 19. The treatment of HeLa cells with 35 microg BME/ml/24 h increased the expression of Bax and Caspase-3, pro-apoptotic proteins (6.13 and 1.2 times for Caspase-3 and Bax, respectively). |
1(0,0,0,1) | Details |
| 19657189 | Shin HC, Song DW, Baek WK, Lee SR, Kwon TK, Lee J, Park SH, Jang BC, Park JW: Anticancer activity and differentially expressed genes in head and neck cancer cells treated with a novel cyclin-dependent kinase inhibitor. Chemotherapy. 2009;55(5):353-62. Epub 2009 Aug 5. In this study, we investigated the antitumor effect and differentially expressed genes (DEGs) in head and neck cancer cells treated by a novel CDK inhibitor, 2-[1,1'-biphenyl]- 4-yl-N-[5-(1,1-dioxo-1lambda (6)-isothiazolidin-2-yl)-1H-indazol-3-yl] acetamide (BAI). RESULTS: Exposure to BAI of 2 different head and neck cancer cell lines, AMC-HN4 and AMC-HN6, induced apoptosis in association with growth inhibition, cell cycle arrest, caspase-3 activation and cytochrome c release. |
1(0,0,0,1) | Details |
| 18423412 | Sheu ML, Chiang CK, Tsai KS, Ho FM, Weng TI, Wu HY, Liu SH: Inhibition of oxidase-related oxidative stress-triggered signaling by honokiol suppresses high -induced human endothelial cell apoptosis. Free Radic Biol Med. 2008 Jun 15;44(12):2043-50. Epub 2008 Apr 3. Honokiol could reduce increased caspase-3 activity and the subsequent apoptosis and cell death triggered by HG. |
1(0,0,0,1) | Details |
| 18641058 | Jin YC, Kim KJ, Kim YM, Ha YM, Kim HJ, Yun UJ, Bae KH, Kim YS, Kang SS, Seo HG, Lee JH, Chang KC: Anti-apoptotic effect of magnolol in myocardial ischemia and reperfusion injury requires extracellular signal-regulated kinase1/2 pathways in rat in vivo. Exp Biol Med. 2008 Oct;233(10):1280-8. Epub 2008 Jul 18. Apoptosis related events such as p-ERK, p-Bad, Bcl-xl and cytochrome c expression were evaluated by Western blot analysis and myocardial caspase-3 activity was also measured. |
1(0,0,0,1) | Details |
| 19246337 | Li R, Zang Y, Li C, Patel NS, Grandis JR, Johnson DE: ABT-737 synergizes with chemotherapy to kill head and neck squamous cell carcinoma cells via a Noxa-mediated pathway. Mol Pharmacol. 2009 May;75(5):1231-9. Epub 2009 Feb 25. Synergism between ABT-737 and chemotherapy was associated with synergistic activation of caspase-3 and cleavage of poly (ADP- polymerase. |
1(0,0,0,1) | Details |
| 19655415 | Yao K, Zhang L, Ye PP, Tang XJ, Zhang YD: Protective effect of magnolol against peroxide-induced oxidative stress in human lens epithelial cells. Am J Chin Med. 2009;37(4):785-96. Magnolol also inhibited H2O2-induced expressions of caspase-9 and caspase-3 and reduction of Bcl-2/Bax ratio. |
1(0,0,0,1) | Details |
| 18276780 | Setzer B, Lebrecht D, Walker UA: Pyrimidine nucleoside depletion sensitizes to the mitochondrial hepatotoxicity of the reverse transcriptase inhibitor stavudine. Am J Pathol. 2008 Mar;172(3):681-90. Epub 2008 Feb 14. Compared with treatment with stavudine alone, co-treatment with redoxal accelerated mtDNA depletion, impaired cell division, and activated caspase 3. |
1(0,0,0,1) | Details |
| 18661240 | Longpre JM, Loo G: Protection of human colon epithelial cells against by rottlerin. Apoptosis. 2008 Sep;13(9):1162-71. In elucidating its mechansim, rottlerin prevented the release of cytochrome c from mitochondria into cytosol, and also prevented the cleavage of caspase-3. |
1(0,0,0,1) | Details |
| 18987944 | Bellocco E, Barreca D, Lagana G, Leuzzi U, Tellone E, Ficarra S, Kotyk A, Galtieri A: Influence of L-rhamnosyl-D-glucosyl derivatives on properties and biological interaction of flavonoids. Mol Cell Biochem. 2009 Jan;321(1-2):165-71. Epub 2008 Nov 6. induced caspase-3 activation, release of LDH and endogenous accumulation of |
1(0,0,0,1) | Details |