| Name | peroxisome proliferator activated receptor gamma |
|---|---|
| Synonyms | HUMPPARG; PAX8/PPARG fusion gene; NR1C3; PPAR gamma; PPAR gamma2; PPARG; PPARG 1; PPARG 2… |
| Name | biphenyl |
|---|---|
| CAS | 1,1′-biphenyl |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18501502 | Safe S, Papineni S, Chintharlapalli S: Cancer chemotherapy with bis (3'-indolyl) and synthetic analogs. Cancer Lett. 2008 Oct 8;269(2):326-38. Epub 2008 May 22. For example, p-trifluoromethylphenyl, p-t-butylphenyl and p-biphenyl analogs activate peroxisome proliferator-activated receptor gamma (PPARgamma), and p-methoxyphenyl and p-phenyl compounds activate nerve growth factor-induced-Balpha (NGFI-Balpha, Nur77) orphan nuclear receptor. |
82(1,1,1,2) | Details |
| 19147759 | Ichite N, Chougule MB, Jackson T, Fulzele SV, Safe S, Singh M: Enhancement of docetaxel anticancer activity by a novel diindolylmethane compound in human non-small cell lung cancer. Clin Cancer Res. 2009 Jan 15;15(2):543-52. PURPOSE: This study was conducted to examine the cytotoxic effects of a peroxisome proliferator-activated receptor gamma (PPARgamma) agonist, 1,1-bis (3'-indolyl)-1-(p-biphenyl) (DIM-C-pPhC (6) H (5)), alone and in combination with docetaxel in vitro in A549 lung cancer cells and in vivo in nude mice bearing A549 orthotopic lung tumors. |
81(1,1,1,1) | Details |
| 19504532 | Goebel M, Staels B, Unger T, Kintscher U, Gust R: Characterization of new PPARgamma agonists: benzimidazole derivatives - the importance of position 2. ChemMedChem. 2009 Jul;4(7):1136-42. Probing SAR: The 1-(biphenyl-4-ylmethyl)-1H-benzo [d] moiety is known to be an essential structural component of telmisartan for PPARgamma activation. |
65(0,2,2,5) | Details |
| 17764562 | Su Y, Vanderlaag K, Ireland C, Ortiz J, Grage H, Safe S, Frankel AE: 1,1-Bis (3'-indolyl)-1-(p-biphenyl) inhibits basal-like breast cancer growth in athymic nude mice. Breast Cancer Res. 2007;9(4):R56. INTRODUCTION: 1,1-Bis (3'-indolyl)-1-(p-biphenyl) (CDIM9) has been identified as a new peroxisome proliferator-activated receptor (PPAR)-gamma agonist that exhibits both receptor dependent and independent antitumor activities. |
33(0,1,1,3) | Details |
| 19823826 | Guo J, Chintharlapalli S, Lee SO, Cho SD, Lei P, Papineni S, Safe S: Peroxisome proliferator-activated receptor gamma-dependent activity of ring-substituted 1,1-bis (3'-indolyl)-1-(p-biphenyl) methanes in cancer cells. Cancer Chemother Pharmacol. 2009 Oct 13. |
12(0,0,1,7) | Details |
| 19687349 | Kappert K, Tsuprykov O, Kaufmann J, Fritzsche J, Ott I, Goebel M, Bahr IN, Hassle PL, Gust R, Fleck E, Unger T, Stawowy P, Kintscher U: Chronic treatment with losartan results in sufficient serum levels of the metabolite EXP3179 for PPARgamma activation. Hypertension. 2009 Oct;54(4):738-43. Epub 2009 Aug 17. |
6(0,0,0,6) | Details |
| 19376135 | Choi SS, Cha BY, Lee YS, Yonezawa T, Teruya T, Nagai K, Woo JT: Magnolol enhances adipocyte differentiation and uptake in 3T3-L1 cells. Life Sci. 2009 Jun 19;84(25-26):908-14. Epub 2009 Apr 17. AIMS: The nuclear receptor peroxisome proliferator-activated receptor (PPAR) gamma plays an important role in adipocyte differentiation. |
5(0,0,0,5) | Details |
| 18783396 | Jing L, Li WM, Zhou LJ, Li S, Kou JJ, Song J: Expression of renin-angiotensin system and peroxisome proliferator-activated receptors in alcoholic cardiomyopathy. Alcohol Clin Exp Res. 2008 Nov;32(11):1999-2007. Epub 2008 Sep 9. Given that the expression of peroxisome proliferator-activated receptors (PPARalpha and PPARgamma) changes with alterations in cardiac metabolism and myocardial remodeling, this study was designed to test the hypothesis that protein expression of PPARalpha and PPARgamma is correlated with RAS activation in ACM. |
5(0,0,0,5) | Details |
| 19197922 | Goebel M, Clemenz M, Staels B, Unger T, Kintscher U, Gust R: Characterization of new PPARgamma agonists: analysis of telmisartan's structural components. ChemMedChem. 2009 Mar;4(3):445-56. The basic 1-(biphenyl-4-ylmethyl)-1H-benzimidazole scaffold of telmisartan was identified as an essential moiety with either a carboxylic acid or tetrazole group at the C-2 position of the biphenyl. |
5(0,0,0,5) | Details |
| 18162196 | Fliegner D, Westermann D, Riad A, Schubert C, Becher E, Fielitz J, Tschope C, Regitz-Zagrosek V: Up-regulation of PPARgamma in myocardial infarction. Eur J Heart Fail. 2008 Jan;10(1):30-8. Epub 2007 Dec 27. |
5(0,0,0,5) | Details |
| 19301897 | Lin CH, Peng YH, Coumar MS, Chittimalla SK, Liao CC, Lyn PC, Huang CC, Lien TW, Lin WH, Hsu JT, Cheng JH, Chen X, Wu JS, Chao YS, Lee HJ, Juo CG, Wu SY, Hsieh HP: Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor gamma agonists. J Med Chem. 2009 Apr 23;52(8):2618-22. |
4(0,0,0,4) | Details |
| 20158108 | Waki H, Yamauchi T, Kadowaki T: [PPARgamma antagonist as a potential drug for the treatment of obesity and diabetes]. Nippon Rinsho. 2010 Feb;68(2):350-5. |
4(0,0,0,4) | Details |
| 20029960 | Ren L, Li Y, Li Y, Tang R, Hu D, Sheng Z, Liu N: The inhibitory effects of on cardiac hypertrophy through modulating the renin-angiotensin system in diet-induced hypercholesterolemic rats. Cell Biochem Funct. 2010 Jan;28(1):58-65. It has been demonstrated that peroxisome proliferator-activated receptor-gamma (PPARgamma) ligand agonists attenuate cardiac hypertrophy through anti-inflammatory effects. |
3(0,0,0,3) | Details |
| 18560532 | Arsenescu V, Arsenescu RI, King V, Swanson H, Cassis LA: Polychlorinated biphenyl-77 induces adipocyte differentiation and proinflammatory adipokines and promotes obesity and atherosclerosis. Environ Health Perspect. 2008 Jun;116(6):761-8. RESULTS: Low concentrations of PCB-77 or TCDD increased adipocyte differentiation, dehydrogenase activity, and expression of peroxisome proliferator-activated receptor gamma, whereas higher concentrations inhibited adipocyte differentiation. |
1(0,0,0,1) | Details |