| Name | estrogen receptors |
|---|---|
| Synonyms | ER; ERA; ER alpha; ERalpha; ESR; ESR 1; ESR1; ESRA… |
| Name | biphenyl |
|---|---|
| CAS | 1,1′-biphenyl |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19902964 | Williams AB, Weiser PT, Hanson RN, Gunther JR, Katzenellenbogen JA: Synthesis of biphenyl proteomimetics as estrogen receptor-alpha coactivator binding inhibitors. Org Lett. 2009 Dec 3;11(23):5370-3. |
63(0,2,2,3) | Details |
| 18200886 | Owens CV Jr, Lambright C, Bobseine K, Ryan B, Gray LE Jr, Gullett BK, Wilson VS: Identification of estrogenic compounds emitted from the combustion of computer printed circuit boards in electronic waste. Environ Sci Technol. 2007 Dec 15;41(24):8506-11. After HPLC fractionation, GC/MS identified ten chemicals which included bisphenol A; the brominated derivates mono-, di-, and tribisphenol, triphenyl triphenyl phosphine oxide, 4'-bromo-[1,1'-biphenyl]-4-ol,3,5-dibromo-4-hydroxybiphenyl,3,5-dibromo-2- hydroxybiphenyl, and the oxygenated polyaromatic hydrocarbon benzanthrone. The chemical also demonstrated an affinity for binding to the estrogen receptor (ER) with an IC50 of 2 x 10 (-7) M. |
1(0,0,0,1) | Details |
| 19703584 | Yum S, Woo S, Kagami Y, Park HS, Ryu JC: Changes in gene expression profile of medaka with acute toxicity of Arochlor 1260, a polychlorinated biphenyl mixture. Comp Biochem Physiol C Toxicol Pharmacol. 2010 Jan;151(1):51-6. Epub 2009 Aug 22. The transcription of molecular biomarkers known to be involved in endocrine disruption (e.g., vitellogenins, choriogenins, and estrogen receptor alpha) was highly up-regulated. |
1(0,0,0,1) | Details |
| 18439640 | Furuta C, Suzuki AK, Watanabe G, Li C, Taneda S, Taya K: Nitrophenols isolated from diesel exhaust particles promote the growth of MCF-7 breast adenocarcinoma cells. Toxicol Appl Pharmacol. 2008 Aug 1;230(3):320-6. Epub 2008 Mar 10. To further investigate transcriptional activity through the estrogen receptor, MCF-7 cells were transfected with a receptor gene that allowed expression of luciferase enzyme under the control of the regulatory element. |
1(0,0,0,1) | Details |
| 18348622 | Simmons DB, Trudeau VL, Marlatt VL, Moon TW, Sherry JP, Metcalfe CD: Interaction of stilbene compounds with human and rainbow trout estrogen receptors. Environ Toxicol Chem. 2008 Feb;27(2):442-51. Stilbene-related compounds found to act as inhibitors at the estrogen receptor included the plant-derived compound and two formulations of fluorescent whitening agents used in detergents, 4,4'-bis (2-sulfostyryl) biphenyl and diaminostilbene-1. |
35(0,1,1,5) | Details |
| 19307983 | Tamura T, Jamous MA, Kitazato KT, Yagi K, Tada Y, Uno M, Nagahiro S: Endothelial damage due to impaired bioavailability triggers cerebral aneurysm formation in female rats. J Hypertens. 2009 Jun;27(6):1284-92. Immunohistochemically, the expression of eNOS and estrogen receptor alpha (ERalpha) in the vascular wall of hypertensive and OVX rats was decreased; angiotensin II and the nicotinamide adenine dinucleotide phosphate oxidase subunits nicotinamide adenine dinucleotide phosphate oxidase 4 and p22phox were strongly expressed in cerebral aneurysms. |
2(0,0,0,2) | Details |
| 19831396 | Bey E, Marchais-Oberwinkler S, Negri M, Kruchten P, Oster A, Klein T, Spadaro A, Werth R, Frotscher M, Birk B, Hartmann RW: New insights into the SAR and binding modes of bis (hydroxyphenyl) thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitory activity and selectivity. J Med Chem. 2009 Nov 12;52(21):6724-43. E2 stimulates the proliferation of hormone-dependent diseases via activation of the estrogen receptor alpha (ERalpha). |
2(0,0,0,2) | Details |
| 18599599 | Xue B, Zhao Y, Johnson AK, Hay M: Central inhibition of angiotensin II-induced hypertension in male mice and the role of reactive species. Am J Physiol Heart Circ Physiol. 2008 Sep;295(3):H1025-H1032. Epub 2008 Jul 3. The present study used in vivo telemetry recording and in vitro living mouse brain slices to test the hypothesis that the central activation of estrogen receptors in male mice inhibits ANG II-induced hypertension via the modulation of the central ROS production. |
2(0,0,0,2) | Details |
| 17870144 | Jofre MB, Karasov WH: Effect of mono-ortho and di-ortho substituted polychlorinated biphenyl (PCB) congeners on leopard frog survival and sexual development. Chemosphere. 2008 Feb;70(9):1609-19. Epub 2007 Sep 17. PCBs 101 and 70 were selected because they were present in amphibians collected in the Fox River-Green Bay ecosystem and they have the theoretical structural requirements to be able to bind to the estrogen receptor and mediate estrogenic responses. |
1(0,0,0,1) | Details |
| 19626933 | Ferrari S: [Bone remodeling: new therapeutic approaches] . Rev Med Suisse. 2009 Jun 10;5(207):1325-8. Bisphosphonates and selective estrogen receptor modulators decrease bone remodeling by preventing osteoclast-mediated bone resorption, whereas parathyroid hormone/teriparatide increase bone remodeling in favor of new bone formation. |
1(0,0,0,1) | Details |
| 18953099 | Ptak A, Ludewig G, Gregoraszczuk EL: A low halogenated biphenyl (PCB3) increases CYP1A1 expression and activity via the estrogen receptor beta in the porcine ovary. J Physiol Pharmacol. 2008 Sep;59(3):577-88. |
0(0,0,0,0) | Details |
| 19356928 | Sarachine MJ, Janjic JM, Wipf P, Day BW: Biphenyl C-cyclopropylalkylamides: New scaffolds for targeting estrogen receptor beta. Bioorg Med Chem Lett. 2009 May 1;19(9):2404-8. Epub 2009 Mar 25. A second generation library provided three compounds that bind estrogen receptor (ER) alpha. |
1(0,0,0,1) | Details |