| Name | cycloxygenase 2 |
|---|---|
| Synonyms | COX 2; COX2; PHS2; PGG/HS; Cyclooxygenase 2; Cyclooxygenase 2b; Cycloxygenase 2; PGH synthase 2… |
| Name | biphenyl |
|---|---|
| CAS | 1,1′-biphenyl |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19481465 | Schuhly W, Hufner A, Pferschy-Wenzig EM, Prettner E, Adams M, Bodensieck A, Kunert O, Oluwemimo A, Haslinger E, Bauer R: Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4-formation. Bioorg Med Chem. 2009 Jul 1;17(13):4459-65. Epub 2009 May 18. A set of ten derivatives of methylhonokiol, an anti-inflammatory active biphenyl-type neolignan from Magnolia grandiflora, has been evaluated for their in vitro cyclooxygenase-1/2 (COX-1/2) inhibitory activity using assays with purified prostaglandin H synthase (PGHS)-1 and PGHS-2 enzymes as well as for their 5-lipoxygenase (5-LOX) mediated LTB (4) formation inhibitory activity using an assay with activated human polymorphonuclear leukocytes. |
31(0,1,1,1) | Details |
| 19528508 | Murakami Y, Ishii H, Hoshina S, Takada N, Ueki A, Tanaka S, Kadoma Y, Ito S, Machino M, Fujisawa S: Antioxidant and cyclooxygenase-2-inhibiting activity of 4,4'-biphenol, 2,2'-biphenol and Anticancer Res. 2009 Jun;29(6):2403-10. |
2(0,0,0,2) | Details |
| 17804140 | Yen GC, Duh PD, Huang DW, Hsu CL, Fu TY: Protective effect of pine (Pinus morrisonicola Hay.) needle on LDL oxidation and its anti-inflammatory action by modulation of iNOS and COX-2 expression in LPS-stimulated RAW 264.7 macrophages. Food Chem Toxicol. 2008 Jan;46(1):175-85. Epub 2007 Jul 28. The inducible synthase (iNOS) and cyclooxygenase 2 (COX-2) protein expressions in LPS-stimulated RAW 264.7 cells were inhibited by EAE-PN. |
1(0,0,0,1) | Details |
| 18155686 | Wang L, Reiterer G, Toborek M, Hennig B: Changing ratios of omega-6 to omega-3 fatty acids can differentially modulate polychlorinated biphenyl toxicity in endothelial cells. Chem Biol Interact. 2008 Mar 10;172(1):27-38. Epub 2007 Nov 19. Similar protective effects by increasing ALA were observed by measuring NF-kappaB-responsive genes, such as vascular cell adhesion molecule-1 (VCAM-1) and cyclooxygenase-2 (COX-2). |
1(0,0,0,1) | Details |
| 19702785 | Gardiner SM, March JE, Kemp PA, Bennett T: Factors influencing the regional haemodynamic responses to methanandamide and in conscious rats. Br J Pharmacol. 2009 Oct;158(4):1143-52. Epub 2009 Aug 20. BACKGROUND AND PURPOSE: In vitro evidence suggests that metabolism of by cyclooxygenase-2 (COX-2) may be more important when the primary metabolic pathway [i.e. fatty acid amide hydrolase (FAAH)] is inhibited. KEY RESULTS: Inhibition of FAAH with URB597 (cyclohexycarbamic acid 3'-carbamoyl-biphenyl-3-yl-ester) augmented the haemodynamic actions of but there was no effect of COX-2 inhibition with parecoxib, either in the absence or the presence of URB597. |
1(0,0,0,1) | Details |
| 19303869 | Chiang J, Shen YC, Wang YH, Hou YC, Chen CC, Liao JF, Yu MC, Juan CW, Liou KT: Honokiol protects rats against eccentric exercise-induced skeletal muscle damage by inhibiting NF-kappaB induced oxidative stress and inflammation. Eur J Pharmacol. 2009 May 21;610(1-3):119-27. Epub 2009 Mar 20. The degree of muscle damage also paralleled dramatic gene expression for cyclooxygenase-2 (COX-2), inducible synthase (iNOS), and inflammation-associated cytokines (interleukin (IL)-1beta, IL-6, tumor necrosis factor-alpha, and monocyte chemoattractant protein-1), possibly through activation of nuclear factor kappa-B (NF-kappaB), a crucial proinflammatory transcription factor. |
1(0,0,0,1) | Details |
| 18423412 | Sheu ML, Chiang CK, Tsai KS, Ho FM, Weng TI, Wu HY, Liu SH: Inhibition of oxidase-related oxidative stress-triggered signaling by honokiol suppresses high -induced human endothelial cell apoptosis. Free Radic Biol Med. 2008 Jun 15;44(12):2043-50. Epub 2008 Apr 3. Moreover, honokiol (0.125-1 microM) also suppressed HG-induced cyclooxygenase (COX)-2 upregulation and (2) production in HUVECs. |
1(0,0,0,1) | Details |
| 19105592 | Wangpradit O, Mariappan SV, Teesch LM, Duffel MW, Norstrom K, Robertson LW, Luthe G: Oxidation of 4-chlorobiphenyl metabolites to electrophilic species by prostaglandin H synthase. Chem Res Toxicol. 2009 Jan;22(1):64-71. We found that human recombinant PGHS-2 catalyzed the oxidation of ortho (2',3'- and 3',4'-) and para (2',5'-) dihydroxy 4-chlorobiphenyl metabolites to their corresponding quinones. |
1(0,0,0,1) | Details |
| 18688813 | Yoo EA, Kim SD, Lee WM, Park HJ, Kim SK, Cho JY, Min W, Rhee MH: Evaluation of antioxidant, antinociceptive, and anti-inflammatory activities of extracts from Aloe saponaria Haw. Phytother Res. 2008 Oct;22(10):1389-95. Moreover, fractions potently suppressed the expression of cycloxygenase (COX)-2 and granulocyte-macrophage colony-stimulating factor (GM-CSF), which are stimulated by LPS in RAW264.7 cells. |
1(0,0,0,1) | Details |
| 18241858 | Lee SY, Yuk DY, Song HS, Yoon do Y, Jung JK, Moon DC, Lee BS, Hong JT: Growth inhibitory effects of obovatol through induction of apoptotic cell death in prostate and colon cancer by blocking of NF-kappaB. Eur J Pharmacol. 2008 Mar 17;582(1-3):17-25. Epub 2008 Jan 5. Correlated well with the induction of apoptosis, obovatol increased the expression of the apoptotic genes; Bax, caspase-3, caspase-9, whereas inhibited expression of anti-apoptotic genes; Bcl-2, inhibitor of apoptosis protein (IAP-1) and X chromosome IAP (XIAP) as well as the cell proliferation marker genes; Cox-2, c-Fos, c-Jun and cyclin D1. |
1(0,0,0,1) | Details |