Protein Information

Name Tyrosinase
Synonyms LB24 AB; Monophenol monooxygenase; OCA1A; OCAIA; SK29 AB; TYR; TYR protein; Tumor rejection antigen AB…

Compound Information

Name biphenyl
CAS 1,1′-biphenyl

Reference List

PubMed Abstract RScore(About this table)
19610592 Manini P, Napolitano A, Westerhof W, Riley PA, d'Ischia M: A reactive ortho-quinone generated by tyrosinase-catalyzed oxidation of the skin depigmenting agent monobenzone: self-coupling and thiol-conjugation reactions and possible implications for melanocyte toxicity. Chem Res Toxicol. 2009 Aug;22(8):1398-405.

Preparative scale oxidation of 1 with tyrosinase and catalytic l-DOPA, followed by reductive workup and acetylation, led to the isolation of two main products that were identified as the acetylated catechol derivative 4 and an unusual biphenyl-type dimer of 4, acetylated 5, arising evidently by coupling of 4 with 1-quinone.
35(0,1,1,5) Details
18573327 Momtaz S, Mapunya BM, Houghton PJ, Edgerly C, Hussein A, Naidoo S, Lall N: Tyrosinase inhibition by extracts and constituents of Sideroxylon inerme L. stem bark, used in South Africa for skin lightening. J Ethnopharmacol. 2008 Oct 28;119(3):507-12. Epub 2008 Jun 13.

6(0,0,0,6) Details
18350234 Donsing P, Limpeanchob N, Viyoch J: Evaluation of the effect of Thai breadfruit's heartwood extract on melanogenesis-inhibitory and antioxidation activities. J Cosmet Sci. 2008 Jan-Feb;59(1):41-58.


The ether extract was then evaluated for tyrosinase-inhibitory, melanogenesis-inhibitory, and antioxidant activities.
4(0,0,0,4) Details
19652388 Chen LG, Chang WL, Lee CJ, Lee LT, Shih CM, Wang CC: Melanogenesis inhibition by gallotannins from Chinese galls in B16 mouse melanoma cells. Biol Pharm Bull. 2009 Aug;32(8):1447-52.


The 70% acetone extracts of 10 kinds of herbs were investigated for their mushroom tyrosinase activity inhibition.
4(0,0,0,4) Details
19270380 Morimura K, Hiramatsu K, Yamazaki C, Hattori Y, Makabe H, Hirota M: Daedalin A, a metabolite of Daedalea dickinsii, inhibits melanin synthesis in an in vitro human skin model. Biosci Biotechnol Biochem. 2009 Mar 23;73(3):627-32. Epub 2009 Mar 7.


The culture broth of Daedalea dickinsii was found to predominantly contain the tyrosinase inhibitor, (2R)-6-hydroxy-2-hydroxymethyl-2-methyl-2H-chromene, daedalin A (1).
3(0,0,0,3) Details
19467035 Khazaeli P, Goldoozian R, Sharififar F: An evaluation of extracts of five traditional medicinal plants from Iran on the inhibition of mushroom tyrosinase activity and scavenging of free radicals. Int J Cosmet Sci. 2009 Oct;31(5):375-81.

3(0,0,0,3) Details
19359068 Lee KH, Ab Aziz FH, Syahida A, Abas F, Shaari K, Israf DA, Lajis NH: Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities. Eur J Med Chem. 2009 Aug;44(8):3195-200. Epub 2009 Mar 26.

2(0,0,0,2) Details
19282644 Fukai S, Tanimoto S, Maeda A, Fukuda H, Okada Y, Nomura M: Pharmacological activity of compounds extracted from persimmon peel (Diospyros kaki THUNB.). J Oleo Sci. 2009;58(4):213-9.


And (8) had higher tyrosinase inhibiting activity than that of arbutin using both L-tyrosine and L-DOPA as substrates.
2(0,0,0,2) Details
18806960 Choi MY, Song HS, Hur HS, Sim SS: Whitening activity of luteolin related to the inhibition of cAMP pathway in alpha-MSH-stimulated B16 melanoma cells. Arch Pharm Res. 2008 Sep;31(9):1166-71. Epub 2008 Sep 20.


To examine the possibility of luteolin as a whitening agent, we measured antioxidant activity using DPPH assay, NBT/XO assay and intracellular ROS scavengning assay and depigmenting activity using tyrosinase assay, alpha-MSH-induced melanin production in B-16 cells.
1(0,0,0,1) Details
17986791 Morimura K, Yamazaki C, Hattori Y, Makabe H, Kamo T, Hirota M: A tyrosinase inhibitor, Daedalin A, from mycelial culture of Daedalea dickinsii. Biosci Biotechnol Biochem. 2007 Nov;71(11):2837-40. Epub 2007 Nov 7.

2(0,0,0,2) Details
19731133 Dai Y, Zhou GX, Kurihara H, Ye WC, Yao XS: A biphenyl glycoside from Pyracantha fortuneana. Nat Prod Res. 2009;23(13):1163-7.

Compounds 1-3 showed mild inhibitory activity against tyrosinase.
1(0,0,0,1) Details
19814867 Song HS, Sim SS: Acteoside inhibits alpha-MSH-induced melanin production in B16 melanoma cells by inactivation of adenyl cyclase. J Pharm Pharmacol. 2009 Oct;61(10):1347-51.


METHODS: We used tyrosinase activity and melanin production stimulated in B16 melanoma cells by alpha-melanocyte stimulating hormone (alpha-MSH) or forskolin to measure the whitening effect of acteoside.
1(0,0,0,1) Details
17886844 Xu M, Zha ZJ, Qin XL, Zhang XL, Yang CR, Zhang YJ: Phenolic antioxidants from the whole plant of Phyllanthus urinaria. Chem Biodivers. 2007 Sep;4(9):2246-52.


The antioxidant activities and mushroom-tyrosinase-inhibitory activities of all compounds were determined by DPPH-radical-scavenging and mushroom-tyrosinase-inhibitory assays (Table 2).
1(0,0,0,1) Details