| Name | Ah receptor |
|---|---|
| Synonyms | AHR; Ah receptor; AhR; Aryl hydrocarbon receptor; Aryl hydrocarbon receptor precursor; Dioxin receptor; Ah receptors; AhRs… |
| Name | biphenyl |
|---|---|
| CAS | 1,1′-biphenyl |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19144771 | Buckley DB, Klaassen CD: Induction of mouse UDP-glucuronosyltransferase mRNA expression in liver and intestine by activators of aryl-hydrocarbon receptor, constitutive androstane receptor, pregnane X receptor, peroxisome proliferator-activated receptor alpha, and nuclear factor erythroid 2-related factor 2. Drug Metab Dispos. 2009 Apr;37(4):847-56. Epub 2009 Jan 14. Male C57BL/6 mice were treated for four consecutive days with activators of AhR [2,3,7,8-tetrachlorodibenzodioxin (TCDD), polychlorinated biphenyl 126, and beta-naphthoflavone], CAR [1,4-bis [2-(3,5-dichloropyridyloxy)] (TCPOBOP), phenobarbital, and diallyl sulfide], PXR -16alpha-carbonitrile (PCN), spironolactone, and dexamethasone], PPARalpha (clofibrate, ciprofibrate, and diethylhexylphthalate), and Nrf2 (oltipraz, ethoxyquin, and butylated hydroxyanisole), respectively. |
36(0,1,1,6) | Details |
| 19692669 | Carlson EA, McCulloch C, Koganti A, Goodwin SB, Sutter TR, Silkworth JB: Divergent transcriptomic responses to aryl hydrocarbon receptor agonists between rat and human primary hepatocytes. Toxicol Sci. 2009 Nov;112(1):257-72. Epub 2009 Aug 19. This study employed toxicogenomic technology to reveal species differences in response to two prototypical aryl hydrocarbon receptor (AHR) agonists 2,3,7,8-tetrachlorodibenzo-p-dioxin and the polychlorinated biphenyl (PCB) congener PCB 126. |
82(1,1,1,2) | Details |
| 18311929 | Alonso M, Casado S, Miranda C, Tarazona JV, Navas JM, Herradon B: Decabromobiphenyl (PBB-209) activates the aryl hydrocarbon receptor while decachlorobiphenyl (PCB-209) is inactive: experimental evidence and computational rationalization of the different behavior of some halogenated biphenyls. Chem Res Toxicol. 2008 Mar;21(3):643-58. Epub 2008 Mar 1. |
7(0,0,0,7) | Details |
| 18786521 | Lim EJ, Majkova Z, Xu S, Bachas L, Arzuaga X, Smart E, Tseng MT, Toborek M, Hennig B: Coplanar polychlorinated biphenyl-induced CYP1A1 is regulated through caveolae signaling in vascular endothelial cells. Chem Biol Interact. 2008 Nov 25;176(2-3):71-8. Epub 2008 Aug 22. We focused on the role of caveolae and their major protein component, caveolin-1 (Cav-1), on aryl hydrocarbon receptor (AhR)-mediated induction of cytochrome P450 1A1 (CYP1A1) by coplanar PCBs. |
2(0,0,0,2) | Details |
| 19344927 | Luo J, Ma M, Zha J, Wang Z: Characterization of aryl hydrocarbon receptor agonists in sediments of Wenyu River, Beijing, China. Water Res. 2009 May;43(9):2441-8. Epub 2009 Mar 20. |
2(0,0,0,2) | Details |
| 18399641 | Tsutsumi T, Amakura Y, Ashieda K, Okuyama A, Tanioka Y, Sakata K, Kobayashi Y, Sasaki K, Maitani T: PCB 118 and Aryl Hydrocarbon Receptor Immunoassays for Screening Dioxins in Retail Fish. J Agric Food Chem. 2008 May 14;56(9):2867-74. Epub 2008 Apr 10. The coplanar PCB-EIA system, which is a competitive immunoassay specific for polychlorinated biphenyl (PCB) 118, was tested as a screening method for mono- ortho PCBs. |
2(0,0,0,2) | Details |
| 18602130 | Royland JE, Kodavanti PR: Gene expression profiles following exposure to a developmental neurotoxicant, Aroclor 1254: pathway analysis for possible mode (s) of action. Toxicol Appl Pharmacol. 2008 Sep 1;231(2):179-96. Epub 2008 May 6. Epidemiological studies indicate that low levels of polychlorinated biphenyl (PCB) exposure can adversely affect neurocognitive development. Functional analysis suggests that pathways related to homeostasis (Gng3, Ryr2, Trdn, Cacna1a), intracellular signaling (Camk2d, Stk17b, Pacsin2, Ryr2, Trio, Fert2, Ptk2b), axonal guidance (Lum, Mxd3, Akap11, Gucy1b3), aryl hydrocarbon receptor signaling (Nfia, Col1a2), and transcripts involved in cell proliferation (Gspt2, Cdkn1c, Ptk2b) and differentiation (Ifitm31, Hpca, Zfp260, Igsf4a, Hes5) leading to the development of nervous system were significantly altered by Aroclor 1254 exposure. |
1(0,0,0,1) | Details |
| 18560532 | Arsenescu V, Arsenescu RI, King V, Swanson H, Cassis LA: Polychlorinated biphenyl-77 induces adipocyte differentiation and proinflammatory adipokines and promotes obesity and atherosclerosis. Environ Health Perspect. 2008 Jun;116(6):761-8. For in vivo studies, we treated C57BL/6 wild-type (WT) or aryl hydrocarbon receptor (AhR)(-/-) mice with vehicle or PCB-77 (49 mg/kg, by intraperitoneal injection) and examined body weight gain. |
2(0,0,0,2) | Details |
| 20170748 | Soffientino B, Nacci DE, Specker JL: Effects of the dioxin-like PCB 126 on larval summer flounder (Paralichthys dentatus). Comp Biochem Physiol C Toxicol Pharmacol. 2010 Feb 16. Larval and metamorphosing summer flounder (Paralichthys dentatus) were exposed to the dioxin-like polychlorinated biphenyl congener PCB 126, to compare their sensitivity to other fish species early life stages, and to document effects on metamorphic development, including degree of eye migration and gastric maturation. Consistent with the presence of a functional aryl hydrocarbon receptor pathway, dose-dependent induction of cytochrome P-4501A (CYP1A) at four days post-exposure was observed in liver, stomach, intestine, and kidney of metamorphosing larvae. |
1(0,0,0,1) | Details |
| 20204344 | Wilson LK, Harris ML, Trudeau S, Ikonomou MG, Elliott JE: Properties of Blood, Porphyrins, and Exposure to Legacy and Emerging Persistent Organic Pollutants in Surf Scoters (Melanitta perspicillata) Overwintering on the South Coast of British Columbia, Canada. Arch Environ Contam Toxicol. 2010 Mar 5. Hepatic organochlorine pesticide, polychlorinated dibenzo-p-dioxin, polychlorinated dibenzofuran, polychlorinated biphenyl (PCB), polybrominated diphenyl ether, and nonylphenol concentrations were relatively low; for example, SigmaTEQs (toxic equivalents) for PCBs, dioxins, and furans combined ranged from 4.7 ng/kg wet weight in reference-site (Baynes Sound) birds to 11.4 ng/kg wet weight in birds from Vancouver Harbour. Nonetheless, elevated EROD activity indicated that birds in Howe Sound were responding to an Ah-receptor-mediated stressor, which was also affecting hematocrit values and possibly status. |
1(0,0,0,1) | Details |
| 18274624 | Robertson LW, Berberian I, Borges T, Chen LC, Chow CK, Glauert HP, Filser JG, Thomas H: Suppression of Peroxisomal Enzyme Activities and Cytochrome P450 4A Isozyme Expression by Congeneric Polybrominated and Polychlorinated Biphenyls. PPAR Res. 2007;2007:15481. None of the peroxisomal enzyme activities were significantly increased by any of the halogenated biphenyl congeners tested. The two Ah receptor agonists, 3,3',4,4'-tetrabromobiphenyl and 3,3',4,4',5-pentachlorobiphenyl, significantly diminished the liver content of CYP4A proteins and activities of the peroxisomal enzymes studied. |
1(0,0,0,1) | Details |
| 18178546 | Silkworth JB, Carlson EA, McCulloch C, Illouz K, Goodwin S, Sutter TR: Toxicogenomic analysis of gender, chemical, and dose effects in livers of TCDD- or aroclor 1254-exposed rats using a multifactor linear model. Toxicol Sci. 2008 Apr;102(2):291-309. Epub 2008 Jan 3. The relative potency of dioxins and polychlorinated biphenyl mixtures, such as Aroclor 1254, is often estimated using the internationally endorsed toxic equivalency (TEQ) approach. The known aryl hydrocarbon receptor (AHR) battery genes (Cyp1a1, Cyp1a2, Cyp1b1, Aldh3a1), and novel genes, responded in a TEQ dose-dependent manner in both genders. |
1(0,0,0,1) | Details |
| 18681238 | Sisman T, Geyikoglu F, Atamanalp M: Early life-stage toxicity in zebrafish (Danio rerio) following embryonal exposure to selected polychlorinated biphenyls. Toxicol Ind Health. 2007 Oct;23(9):529-36. The inhibition of swim bladder inflation was the most sensitive endpoint measured, and it is suggested that the inhibition of swim bladder inflation may be mediated by mechanism with an aryl hydrocarbon receptor activation. In this article, specific polychlorinated biphenyl congeners were examined for embryo and early life-stage toxicity in zebrafish (Danio rerio). |
1(0,0,0,1) | Details |
| 19969354 | Lai I, Chai Y, Simmons D, Luthe G, Coleman MC, Spitz D, Haschek WM, Ludewig G, Robertson LW: Acute toxicity of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) in male Sprague-Dawley rats: Effects on hepatic oxidative stress, and metals status. Environ Int. 2009 Dec 5. Although polychlorinated biphenyl (PCBs) production, and new uses for PCBs, was halted in the 1970s in the United States, PCBs continue to be used in closed systems and persist in the environment, accumulating in fatty tissues. The goal of the present study was to evaluate the effects of a single, very low dose of PCB 126 (3,3',4,4',5-pentachlorobiphenyl), a coplanar, dioxin-like PCB congener and aryl hydrocarbon receptor (AhR) agonist, on redox status, metals homeostasis, antioxidant enzymes, and cellular morphology. |
1(0,0,0,1) | Details |
| 19616879 | Hansson MC, Persson ME, Larsson P, von Schantz T: Polychlorinated biphenyl (PCB) load, lipid reserves and biotransformation activity in migrating Atlantic salmon from River Morrum, Sweden. Environ Pollut. 2009 Dec;157(12):3396-403. Epub 2009 Jul 18. For these analyses we sampled adult Atlantic salmon during migration in the Swedish River Morrum and measured the 21 most common PCB congeners ( summation operatorPCB) and lipid levels in muscle tissue, aryl hydrocarbon receptor (AHR2) and cytochrome P4501A1 (CYP1A1) transcript levels as well as ethoxyresorufin-O-deethylase activity (EROD) in liver. |
1(0,0,0,1) | Details |
| 18953099 | Ptak A, Ludewig G, Gregoraszczuk EL: A low halogenated biphenyl (PCB3) increases CYP1A1 expression and activity via the estrogen receptor beta in the porcine ovary. J Physiol Pharmacol. 2008 Sep;59(3):577-88. |
0(0,0,0,0) | Details |