| Name | p38 |
|---|---|
| Synonyms | AIMP 2; p38; AIMP2; JTV 1; JTV1; JTV1 gene; JTV1 protein; Multisynthetase complex auxiliary component p38… |
| Name | biphenyl |
|---|---|
| CAS | 1,1′-biphenyl |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18006306 | Angell RM, Bamborough P, Cleasby A, Cockerill SG, Jones KL, Mooney CJ, Somers DO, Walker AL: Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode. Bioorg Med Chem Lett. 2008 Jan 1;18(1):318-23. Epub 2007 Nov 19. |
31(0,1,1,1) | Details |
| 18602262 | Angell RM, Angell TD, Bamborough P, Bamford MJ, Chung CW, Cockerill SG, Flack SS, Jones KL, Laine DI, Longstaff T, Ludbrook S, Pearson R, Smith KJ, Smee PA, Somers DO, Walker AL: Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4433-7. Epub 2008 Jun 12. |
31(0,1,1,1) | Details |
| 18801463 | Lee SJ, Park SS, Lee US, Kim WJ, Moon SK: Signaling pathway for TNF-alpha-induced MMP-9 expression: mediation through p38 MAP kinase, and inhibition by anti-cancer molecule magnolol in human urinary bladder cancer 5637 cells. Int Immunopharmacol. 2008 Dec 20;8(13-14):1821-6. Epub 2008 Sep 16. |
4(0,0,0,4) | Details |
| 17981461 | Angell RM, Angell TD, Bamborough P, Brown D, Brown M, Buckton JB, Cockerill SG, Edwards CD, Jones KL, Longstaff T, Smee PA, Smith KJ, Somers DO, Walker AL, Willson M: Biphenyl amide p38 kinase inhibitors 2: Optimisation and SAR. Bioorg Med Chem Lett. 2008 Jan 1;18(1):324-8. Epub 2007 Oct 17. |
31(0,1,1,1) | Details |
| 18378223 | Zhou HY, Shin EM, Guo LY, Youn UJ, Bae K, Kang SS, Zou LB, Kim YS: Anti-inflammatory activity of 4-methoxyhonokiol is a function of the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via NF-kappaB, JNK and p38 MAPK inactivation. Eur J Pharmacol. 2008 May 31;586(1-3):340-9. Epub 2008 Feb 26. |
2(0,0,0,2) | Details |
| 18614366 | Angell R, Aston NM, Bamborough P, Buckton JB, Cockerill S, deBoeck SJ, Edwards CD, Holmes DS, Jones KL, Laine DI, Patel S, Smee PA, Smith KJ, Somers DO, Walker AL: Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4428-32. Epub 2008 Jun 18. |
31(0,1,1,1) | Details |
| 18413146 | Idris A, Mrak E, Greig I, Guidobono F, Ralston SH, van 't Hof R: ABD56 causes osteoclast apoptosis by inhibiting the NFkappaB and ERK pathways. Biochem Biophys Res Commun. 2008 Jun 20;371(1):94-8. Epub 2008 Apr 14. ABD56 caused phosphorylation of p38, JNK and nuclear translocation of c-jun in osteoclasts. |
2(0,0,0,2) | Details |
| 18367166 | Chang HL, Chang FR, Chen JS, Wang HP, Wu YH, Wang CC, Wu YC, Hwang TL: Inhibitory effects of 16-hydroxycleroda-3,13 (14) E-dien-15-oic acid on and elastase release in human neutrophils through multiple mechanisms. Eur J Pharmacol. 2008 May 31;586(1-3):332-9. Epub 2008 Mar 4. Furthermore, PL3S attenuated the FMLP-induced protein kinase B (AKT) and p38 mitogen-activated protein kinase phosphorylation. |
2(0,0,0,2) | Details |
| 18507762 | Deng J, Qian Y, Geng L, Chen J, Wang X, Xie H, Yan S, Jiang G, Zhou L, Zheng S: Involvement of p38 mitogen-activated protein kinase pathway in honokiol-induced apoptosis in a human hepatoma cell line (hepG2). Liver Int. 2008 Dec;28(10):1458-64. Epub 2008 May 26. Western blots were used to analyse the expression of various proteins (procaspase-9, procaspase-3, cleaved caspase-3, cytochrome c, Bcl-2, Bax, Bad, Bcl-X (L) and p38). |
2(0,0,0,2) | Details |
| 18959758 | Yamamoto A, Nunoshiba T, Umezu K, Enomoto T, Yamamoto K: Phenyl an Ames test-negative carcinogen, induces Hog1-dependent stress response signaling. FEBS J. 2008 Nov;275(22):5733-44. Furthermore, Hog1 (a p38 MAPK homolog) was robustly phosphorylated by phenyl which can stabilize Swe1. |
1(0,0,0,1) | Details |
| 18956176 | Yu YN, Chen H, Li Y: Protect effect of bicyclol on cisplatin-induced nephrotoxicity in mice. Arch Toxicol. 2009 Apr;83(4):381-7. Epub 2008 Oct 28. Bicyclol suppressed cisplatin-induced extracelluar signal regulated kinases 1/2 and p38 mitogen-activated protein kinase activation in the kidney of mice. |
1(0,0,0,1) | Details |
| 18809416 | Tang HB, Li YS, Miyano K, Nakata Y: Phosphorylation of TRPV1 by neurokinin-1 receptor agonist exaggerates the -mediated substance P release from cultured rat dorsal root ganglion neurons. Neuropharmacology. 2008 Dec;55(8):1405-11. Epub 2008 Sep 17. The increase in the TRPV1 phosphorylated forms induced by a 60-min exposure to GR73632 was completely abolished by the inhibition of either PKC, COX or PLC, p38 or p42/44 MAP kinases. |
1(0,0,0,1) | Details |
| 19655415 | Yao K, Zhang L, Ye PP, Tang XJ, Zhang YD: Protective effect of magnolol against peroxide-induced oxidative stress in human lens epithelial cells. Am J Chin Med. 2009;37(4):785-96. Moreover, magnolol attenuated the deactivation of ERK/MAPK (extracellular signal-regulated kinase/mitogen activated protein kinase) and the enhanced activation of p38, JNK (c-Jun N-terminal kinase) induced by H2O2. |
1(0,0,0,1) | Details |
| 18207396 | Peifer C, Urich R, Schattel V, Abadleh M, Rottig M, Kohlbacher O, Laufer S: Implications for selectivity of 3,4-diarylquinolinones as p38alphaMAP kinase inhibitors. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1431-5. Epub 2008 Jan 5. In this study we report on the specificity profiling of the MAP kinase inhibitors 1, 2, and 3 in a panel of 78 protein kinases including the MAPK isoforms p38 (alpha,beta,gamma,delta), JNK1/2/3, and ERK1/2/8 showing 3-(4-fluorophenyl)-4-pyridin-4-ylquinolin-2 (1H)-one (1) to be highly selective for p38alphaMAPK with an IC (50) of 1.8 microM. |
1(0,0,0,1) | Details |