Protein Information

Name NK1
Synonyms BY55; CD160; CD160 antigen; CD160 antigen precursor; CD160 molecule; NK1; NK28; Natural killer cell receptor BY55…

Compound Information

Name biphenyl
CAS 1,1′-biphenyl

Reference List

PubMed Abstract RScore(About this table)
18187929 Watanabe Y, Asai H, Ishii T, Kiuchi S, Okamoto M, Taniguchi H, Nagasaki M, Saito A: Pharmacological characterization of T-2328, 2-fluoro-4'-methoxy-3'-[[[(2S,3S)-2-phenyl-3-piperidinyl] amino] methyl]-[1, 1'-biphenyl]-4-carbonitrile dihydrochloride, as a brain-penetrating antagonist of tachykinin NK1 receptor. J Pharmacol Sci. 2008 Jan;106(1):121-7. Epub 2008 Jan 11.
81(1,1,1,1) Details
18930727 Haddjeri N, Blier P: Neurokinin-1 receptor antagonists modulate brain noradrenaline and serotonin interactions. Eur J Pharmacol. 2008 Dec 14;600(1-3):64-70. Epub 2008 Oct 9.


Substance P (neurokinin-1; NK1) receptor antagonists represent a putative new class of antidepressant/anxiolytic drugs.
2(0,0,0,2) Details
19279355 Yaraee R, Ghazanfari T: Substance P potentiates TGFbeta-1 production in lung epithelial cell lines. Iran J Allergy Asthma Immunol. 2009 Mar;8(1):19-24.


We have observed that SP (without any other stimulator) significantly augments TGF-beta production of both BEAS and A54 cells and this effect is inhibited by NK1-receptor antagonist (CP-96345).
1(0,0,0,1) Details