Protein Information

Name angiotensin converting enzyme 2
Synonyms ACE 2; ACE related carboxypeptidase; ACE2; ACEH; Angiotensin I converting enzyme (peptidyl dipeptidase A) 2; Angiotensin converting enzyme 2; Angiotensin converting enzyme 2 precursor; Angiotensin converting enzyme homolog…

Compound Information

Name biphenyl
CAS 1,1′-biphenyl

Reference List

PubMed Abstract RScore(About this table)
19808375 Kassiri Z, Zhong J, Guo D, Basu R, Wang X, Liu PP, Scholey JW, Penninger JM, Oudit GY: Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction. Circ Heart Fail. 2009 Sep;2(5):446-55. Epub 2009 Jun 15.

7(0,0,0,7) Details
18243695 Deaton DN, Graham KP, Gross JW, Miller AB: Thiol-based angiotensin-converting enzyme 2 inhibitors: P1' modifications for the exploration of the S1' subsite. Bioorg Med Chem Lett. 2008 Mar 1;18(5):1681-7. Epub 2008 Jan 18.

Explorations of the S (1') subsite of ACE2 via modifications of the P (1') methylene biphenyl moiety of thiol-based metalloprotease inhibitors led to improvements in ACE2 selectivity versus ACE and NEP, while maintaining potent ACE2 inhibition.
82(1,1,1,2) Details