| Name | MCH1R |
|---|---|
| Synonyms | G protein coupled receptor 24; GPR24; MCH receptor 1; MCH 1R; MCH R1; MCH1R; MCHR; MCHR 1… |
| Name | biphenyl |
|---|---|
| CAS | 1,1′-biphenyl |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17897032 | Hertzog DL, Witty DR: Biphenyl amides and isosteres as MCH R1 antagonists. . Curr Top Med Chem. 2007;7(15):1455-70. |
65(0,2,2,5) | Details |
| 19137910 | Cirauqui N, Ceras J, Galiano S, Perez-Silanes S, Juanenea L, Rivera G, Aldana I, Monge A: New amide derivatives as melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity. Arzneimittelforschung. 2008;58(11):585-91. The results showed that diphenyl substituents on the amide lead to better activity than biphenyl substituents. |
2(0,0,0,2) | Details |
| 17897030 | DeVita RJ: Aminoquinoline melanin-concentrating hormone 1-receptor (MCH1-R) antagonists. Curr Top Med Chem. 2007;7(15):1433-9. Improvements to the original screening lead were made by addition of lipophilic groups at the 2-position and biphenyl, cyclohexyl phenyl and hydrocinnamyl carboxamides at the 6-position. Transposition of the 4-amino group to the 2-position of the quinoline core structure provided the 2-aminoquinoline lead class with similar MCH1R binding affinity. |
2(0,0,0,2) | Details |
| 19540226 | Able SL, Ivarsson M, Fish RL, Clarke TL, McCourt C, Duckworth JM, Napier C, Katugampola SD: Localisation of melanin-concentrating hormone receptor 1 in rat brain and evidence that sleep parameters are not altered despite high central receptor occupancy. Eur J Pharmacol. 2009 Aug 15;616(1-3):101-6. Epub 2009 Jun 18. The present study describes the optimisation of an autoradiography assay that provides a means to measure the in vitro potency of melanin-concentrating hormone receptor 1 (MCH (1)) antagonists in native tissues and their ex vivo receptor occupancy. |
1(0,0,0,1) | Details |