| Name | IL 1beta |
|---|---|
| Synonyms | Catabolin; IL 1; IL 1 beta; IL 1B; IL1 beta; IL1B; IL1F2; Interleukin 1… |
| Name | biphenyl |
|---|---|
| CAS | 1,1′-biphenyl |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19303869 | Chiang J, Shen YC, Wang YH, Hou YC, Chen CC, Liao JF, Yu MC, Juan CW, Liou KT: Honokiol protects rats against eccentric exercise-induced skeletal muscle damage by inhibiting NF-kappaB induced oxidative stress and inflammation. Eur J Pharmacol. 2009 May 21;610(1-3):119-27. Epub 2009 Mar 20. The degree of muscle damage also paralleled dramatic gene expression for cyclooxygenase-2 (COX-2), inducible synthase (iNOS), and inflammation-associated cytokines (interleukin (IL)-1beta, IL-6, tumor necrosis factor-alpha, and monocyte chemoattractant protein-1), possibly through activation of nuclear factor kappa-B (NF-kappaB), a crucial proinflammatory transcription factor. |
1(0,0,0,1) | Details |
| 17869312 | Chenevier-Gobeaux C, Simonneau C, Therond P, Bonnefont-Rousselot D, Poiraudeau S, Ekindjian OG, Borderie D: Implication of cytosolic phospholipase A2 (cPLA2) in the regulation of human synoviocyte oxidase (Nox2) activity. Life Sci. 2007 Sep 8;81(13):1050-8. Epub 2007 Aug 25. production was quantified in synovial cells obtained from six patients with rheumatoid arthritis (RA) and six with osteoarthritis (OA), stimulated with (i) AA, and (ii) PLA (2) inhibitors prior to IL-1beta or TNF-alpha treatment. |
4(0,0,0,4) | Details |
| 19107823 | Lee KH, Kim AJ, Choi EM: Antioxidant and antiinflammatory activity of pine pollen extract in vitro. Phytother Res. 2009 Jan;23(1):41-8. Thereafter, the study investigated the effects of PPE in modulating the production of pro-inflammatory mediators in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages, and the effect of PPE on interleukin (IL)-1beta-induced matrix metalloproteinases (MMPs) production and mitogen-activated protein kinases (MAPKs) activation in the human synovial sarcoma cell line, SW982. |
3(0,0,0,3) | Details |
| 19180509 | Li X, Ellman M, Muddasani P, Wang JH, Cs-Szabo G, van Wijnen AJ, Im HJ: and its cognate EP receptors control human adult articular cartilage homeostasis and are linked to the pathophysiology of osteoarthritis. Arthritis Rheum. 2009 Feb;60(2):513-23. PGE (2) titration combined with interleukin-1 (IL-1) synergistically accelerated expression of pain-associated molecules such as inducible synthase and IL-6. |
1(0,0,0,1) | Details |
| 19211157 | Ashwood P, Schauer J, Pessah IN, Van de Water J: Preliminary evidence of the in vitro effects of BDE-47 on innate immune responses in children with autism spectrum disorders. J Neuroimmunol. 2009 Mar 31;208(1-2):130-5. Epub 2009 Feb 10. A common environmental contaminant, 2,2',4,4'-tetrabrominated biphenyl (BDE-47), was tested for differential effects on the immune response of peripheral blood mononuclear cells (PBMC) isolated from children with ASD (n=19) and age-matched typically developing controls (TD, n=18). In contrast, cells cultured from subjects with ASD demonstrated an increased IL-1beta response to LPS (p=0.033) when pretreated with 100 nM BDE-47 compared with vehicle control. |
1(0,0,0,1) | Details |
| 18287786 | Yamamoto M, Haruna T, Imura K, Hikita I, Furue Y, Higashino K, Gahara Y, Deguchi M, Yasui K, Arimura A: Inhibitory effect of a potent and selective cytosolic phospholipase A2alpha inhibitor RSC-3388 on skin inflammation in mice. Pharmacology. 2008;81(4):301-11. Epub 2008 Feb 21. To examine the contribution of cPLA2alpha to skin inflammation, we evaluated the effect of (E)-N-[(2S,4R)-4-[N-(biphenyl-2-ylmethyl)-N-2-methylpropylamino]-1-[2-(2,4 -difluorobenzoyl) benzoyl] pyrrolidin- 2-yl] methyl-3-[4-(2,4-dioxothiazolidin-5-ylidenemethyl) phenyl] acrylamide (RSC-3388), a potent and selective cPLA2alpha inhibitor, on 2,4,6-trinitro-1-chlorobenzene (TNCB)-induced ear inflammation and mite antigen-induced dermatitis in mice. Comprehensive expression analysis using Gene-Chip technology and subsequent experiments concerning mRNA and protein expression demonstrated that RSC-3388 clearly reduced the levels of interleukin-1beta, macrophage inflammatory protein-1alpha (MIP-1alpha) and MIP-1beta in a TNCB-induced mouse model. |
1(0,0,0,1) | Details |
| 19772287 | Aston NM, Bamborough P, Buckton JB, Edwards CD, Holmes DS, Jones KL, Patel VK, Smee PA, Somers DO, Vitulli G, Walker AL: p38alpha mitogen-activated protein kinase inhibitors: optimization of a series of biphenylamides to give a molecule suitable for clinical progression. J Med Chem. 2009 Oct 22;52(20):6257-69. p38alpha MAP kinase is a key anti-inflammatory target for rheumatoid arthritis, influencing biosynthesis of pro-inflammatory cytokines TNFalpha and IL-1beta at a translational and transcriptional level. |
1(0,0,0,1) | Details |
| 18371952 | Zhao J, Chen H, Li Y: Protective effect of bicyclol on acute -induced liver injury in mice. Eur J Pharmacol. 2008 May 31;586(1-3):322-31. Epub 2008 Feb 29. Over-expression of cytokines, such as tumor necrosis factor alpha and interleukin 1beta, elevated plasma endotoxin level, and up-regulation of CD14 were also suppressed by bicyclol in -intoxicated mice. |
1(0,0,0,1) | Details |
| 20112726 | Yu F: [Protective effects of Angelica sinensis polysaccharide on immunological liver injury induced by concanavalin A in mice]. Zhong Yao Cai. 2009 Oct;32(10):1580-3. METHODS: Sixty NIH mice were randomly divided into 6 groups as normal group, model group, biphenyl group, Angelica sinensis polysaccharide high does group, Angelica sinensis polysaccharide middle dose group and Angelica sinensis polysaccharide low dose group. |
0(0,0,0,0) | Details |