| Name | phospholipase A2 |
|---|---|
| Synonyms | 14 3 3 protein zeta/delta; Phospholipase A2; KCIP 1; Protein kinase C inhibitor protein 1; 14 3 3 protein/cytosolic phospholipase A2; 14 3 3 zeta; FAS; Factor activating exoenzyme S… |
| Name | lindane |
|---|---|
| CAS | (1α,2α,3β,4α,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10613396 | Criswell KA, Loch-Caruso R: Lindane-induced inhibition of spontaneous contractions of pregnant rat uterus. Reprod Toxicol. 1999 Nov-Dec;13(6):481-90. Additionally, the phospholipase A2 inhibitor and antioxidant quinacrine increased the ED50 for contraction force inhibition to 84.5 microM lindane. |
31(0,1,1,1) | Details |
| 10653519 | Tithof PK, Olivero J, Ruehle K, Ganey PE: Activation of neutrophil -dependent and -independent phospholipases A2 by organochlorine compounds. Toxicol Sci. 2000 Jan;53(1):40-7. Phospholipase A2 (PLA2)-mediated release of has been shown to play an essential role in (O2-) production in neutrophils exposed to various physiologic and pharmacologic agents. Therefore, studies were performed to determine if the organochlorine pesticides, lindane and dieldrin, activate neutrophils to produce O2- by a mechanism that requires PLA2. |
1(0,0,0,1) | Details |
| 16686424 | Mariussen E, Fonnum F: Neurochemical targets and behavioral effects of organohalogen compounds: an update. Crit Rev Toxicol. 2006 Mar;36(3):253-89. For instance, several reports have shown that OHCs alter neurotransmitter functions in CNS and Ca2+ homeostatic processes, induce protein kinase C (PKC) and phospholipase A2 (PLA2) mobilization, and induce oxidative stress. In the 1970s it was discovered that PCBs and some chlorinated pesticides, such as lindane, have potentials after both acute and chronic exposure. |
1(0,0,0,1) | Details |
| 11097267 | Lu CH, Lee KC, Chen YC, Cheng JS, Yu MS, Chen WC, Jan CR: Lindane (gamma-hexachlorocyclohexane) induces internal Ca2+ release and capacitative Ca2+ entry in Madin-Darby canine kidney cells. Pharmacol Toxicol. 2000 Oct;87(4):149-55. |
0(0,0,0,0) | Details |