| Name | ATPase |
|---|---|
| Synonyms | ATP7A; MK; ATPase; Cation transporting ATPase; ATP7A protein; ATPase Cu(2+) transporting alpha polypeptide; Copper pump 1; Copper transporting ATPase 1… |
| Name | lindane |
|---|---|
| CAS | (1α,2α,3β,4α,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 1447481 | Janik F, Wolf HU: The Ca (2+)-transport-ATPase of human erythrocytes as an in vitro toxicity test system--acute effects of some chlorinated compounds. J Appl Toxicol. 1992 Oct;12(5):351-8. Investigations to determine the inhibitory activity on the Ca (2+)-transport-ATPase of human erythrocyte membranes were performed with various compounds of toxicological significance, mostly chlorinated and mainly used as biocides, such as 4-chlorophenol, 2,6-dichlorophenol, 3,4-dichlorophenol, 2,3,4-trichlorophenol, 2,3,4,5-tetrachlorophenol, pentachlorophenol (PCP), captan, folpet, captafol, (+)-camphene, toxaphene, dichlorodiphenyltrichloroethane (DDT), lindane, endrin, dieldrin, alpha-endosulfan, beta-endosulfan, paraquat, diallate, 2,4-dichlorophenoxyacetic acid (2,4-D) and 2,4,5-trichlorophenoxyacetic acid (2,4,5-T). |
34(0,1,1,4) | Details |
| 10048752 | Tiemann U, Kuchenmeister U: Influence of organochlorine pesticides on ATPase activities of microsomal fractions of bovine oviductal and endometrial cells. Toxicol Lett. 1999 Jan 11;104(1-2):75-81. In the present study the effects of organochlorine pesticides: o,p'-DDT, p,p''-DDT, methoxychlor, and lindane on ATPase activities of microsomal fractions of bovine oviductal and endometrial cells were investigated. |
8(0,0,1,3) | Details |
| 8896723 | Moreno MJ, Pellicer S, Fernandez-Otero MP: Effects of in situ and systemic lindane treatment on in vivo absorption of and in rat jejunum. Arch Toxicol. 1996;70(11):767-72. In situ lindane treatment (0.3, 0.2 and 0.1 mM) induces a significant decrease in basolateral (Na (+)-K (+)-ATPase activity. |
6(0,0,1,1) | Details |
| 16432761 | Srivastava A, Shivanandappa T: Causal relationship between hexachlorocyclohexane cytotoxicity, oxidative stress and Na+, K +-ATPase in Ehrlich Ascites tumor cells. Mol Cell Biochem. 2006 Jun;286(1-2):87-93. Epub 2006 Jan 24. |
3(0,0,0,3) | Details |
| 19818741 | Srivastava A, Shivanandappa T: Stereospecificity in the cytotoxic action of hexachlorocyclohexane isomers. Chem Biol Interact. 2010 Jan 5;183(1):34-9. Epub . HCH inhibited Na (+),K (+)-ATPase, which could be involved in raising the intracellular and increased Ca (2+),Mg (2+)-ATPase activity. |
2(0,0,0,2) | Details |
| 9989472 | Sahoo A, Samanta L, Das A, Patra SK, Chainy GB: Hexachlorocyclohexane-induced behavioural and neurochemical changes in rat. J Appl Toxicol. 1999 Jan-Feb;19(1):13-8. Effect of chronic oral exposure (10 and 20 mg kg (-1) body wt. for 7, 15 and 30 days) to hexachlorocyclohexane (HCH) on open-field behaviour and activities of cerebral Na+,K+-ATPase, Mg2+-ATPase and acetylcholinesterase (AChE) of rat was evaluated. |
2(0,0,0,2) | Details |
| 7685730 | Agrawal D, Sultana P: Biochemical and structural alterations in rat erythrocytes due to hexachlorocyclohexane exposure. Food Chem Toxicol. 1993 Jun;31(6):443-8. The phospholipid:cholesterol ratio was altered, and there were changes in the activities of the membrane-bound enzymes ATPase and acetylcholinesterase. |
2(0,0,0,2) | Details |
| 7594191 | Anand M, Meera P, Kumar R, Gupta GS, Tripathi O, Srimal RC: Possible role of in the cardiovascular effects of prolonged administration of gamma-HCH (lindane) in rats. J Appl Toxicol. 1995 Jul-Aug;15(4):245-8. The plasma concentration was increased (32%) and Ca,K-ATPase activity in heart was decreased (50%). |
1(0,0,0,1) | Details |
| 17369300 | Endo R, Ohtsubo Y, Tsuda M, Nagata Y: Identification and characterization of genes encoding a putative ABC-type transporter essential for utilization of gamma-hexachlorocyclohexane in Sphingobium japonicum UT26. J Bacteriol. 2007 May;189(10):3712-20. Epub 2007 Mar 16. This putative ABC transporter consists of four components, permease, ATPase, periplasmic protein, and lipoprotein, encoded by linK, linL, linM, and linN, respectively. |
1(0,0,0,1) | Details |
| 7533627 | Moreno MJ, Pellicer S, Marti A, Arenas JC, Fernandez-Otero MP: Effect of lindane on and transport in chicken enterocytes. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1994 Oct;109(2):159-66. Furthermore, the exit of across the basolateral membrane, as well as (Na (+)-K+)-ATPase activity, was significantly decreased in pesticide-treated chickens. |
1(0,0,0,1) | Details |
| 9865422 | Bhalla P, Agrawal D: Alterations in rat erythrocyte membrane due to hexachlorocyclohexane (technical) exposure. Hum Exp Toxicol. 1998 Nov;17(11):638-42. Administration of HCH (technical) to rats at 5 mg/kg, orally, 5 days a week for 1, 2 and 3 months caused marked increase in erythrocyte membrane fluidity, osmotic fragility and decrease in levels of Na+, K (+)-ATPase, acetylcholinesterase in erythrocytes and in blood. 2. |
1(0,0,0,1) | Details |
| 10097797 | Samanta L, Roy A, Chainy GB: Changes in rat testicular antioxidant defence profile as a function of age and its impairment by hexachlorocyclohexane during critical stages of maturation. Andrologia. 1999 Mar;31(2):83-90. On the other hand, hexachlorocyclohexane elevated total testicular Ca (2+)-Mg (2+)-ATPase activity. |
1(0,0,0,1) | Details |
| 16461706 | Schmitt M, Schwanewilm P, Ludwig J, Lichtenberg-Frate H: Use of PMA1 as a housekeeping biomarker for assessment of toxicant-induced stress in Saccharomyces cerevisiae. Appl Environ Microbiol. 2006 Feb;72(2):1515-22. In this study, toxicant-induced stresses of pure compounds were investigated in Saccharomyces cerevisiae utilizing a destabilized version of the green fluorescent protein optimized for expression in yeast (yEGFP3) under control of the promoter of the housekeeping plasma membrane ATPase gene PMA1. Dose-response experiments were conducted in which yeast cells were exposed in minimal medium and in the presence of 20% fetal calf serum to sublethal concentrations of an array of heavy metals, salt, and a number of stress-inducing compounds (Diclofenac, Lindane, methyl-N-nitro-N-nitrosoguanidine [MNNG], hydroxyurea, and |
1(0,0,0,1) | Details |
| 9026152 | Roy A, Chainy GB: Age-related change in rat testicular ATPase activities in response to HCH treatment. Bull Environ Contam Toxicol. 1996 Jan;56(1):165-70. |
1(0,0,0,1) | Details |
| 7532328 | Srivastava SC, Kumar R, Prasad AK, Srivastava SP: Effect of hexachlorocyclohexane (HCH) on testicular plasma membrane of rat. Toxicol Lett. 1995 Jan;75(1-3):153-7. The results indicate inhibition in the activity of the Ca (2+)-ATPase, Na (+)+K (+)+Mg (2+)-ATPase and 5'Nucleotidase. |
1(0,0,0,1) | Details |