| Name | Acetylcholinesterase |
|---|---|
| Synonyms | ACHE; ACHE protein; AChE; ARACHE; AcChoEase; Acetylcholine acetylhydrolase; Acetylcholinesterase; Acetylcholinesterase isoform E4 E6 variant… |
| Name | pirimiphos-methyl |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 1463899 | Hemingway J, Small GJ, Monro A, Sawyer BV, Kasap H: Insecticide resistance gene frequencies in Anopheles sacharovi populations of the Cukurova plain, Adana Province, Turkey. Med Vet Entomol. 1992 Oct;6(4):342-8. Over the 6 years that pirimiphos-methyl has been applied for malaria vector control in this area, the frequency of the altered acetylcholinesterase resistance gene has declined, although in 1989 and 1990 it was still present at measurable frequencies in An.sacharovi from Cukurova. |
8(0,0,1,3) | Details |
| 2335708 | Lock EA, Johnson MK: Delayed neuropathy and acute toxicity studies with pirimiphos-methyl in the hen. J Appl Toxicol. 1990 Feb;10(1):17-21. Hens dosed with pirimiphos-methyl had very low AChE activities (less than 20% of control) in both the brain and spinal cord, 24 and 48 h after dosing. |
7(0,0,1,2) | Details |
| 12485579 | Crane M, Sildanchandra W, Kheir R, Callaghan A: Relationship between biomarker activity and developmental endpoints in Chironomus riparius Meigen exposed to an organophosphate insecticide. Ecotoxicol Environ Saf. 2002 Nov;53(3):361-9. The biomarkers acetylcholinesterase (AChE) and glutathione S-transferase (GST) were measured in fourth-instar Chironomus riparius Meigen larvae exposed to the organophosphate insecticide pirimiphos methyl (0, 5, 10, and 50ng/g) for 48 or 96h, and at high or low food ration. |
7(0,0,1,2) | Details |
| 18240518 | Rodriguez MM, Bisset JA, Fernandez D: Levels of insecticide resistance and resistance mechanisms in Aedes aegypti from some Latin American countries. J Am Mosq Control Assoc. 2007 Dec;23(4):420-9. Biochemical tests showed high frequencies of esterase and glutathione-S-transferase activity; however, the frequency of altered acetylcholinesterase mechanism was low. Eight Latin American strains of Aedes aegypti were evaluated for resistance to 6 organophosphates (temephos, malathion, fenthion, pirimiphos-methyl, fenitrothion, and chlorpirifos) and 4 pyrethroids (deltamethrin, lambdacyhalothrin, betacypermethrin, and cyfluthrin) under laboratory conditions. |
1(0,0,0,1) | Details |
| 19115232 | Roditakis E, Grispou M, Morou E, Kristoffersen JB, Roditakis N, Nauen R, Vontas J, Tsagkarakou A: Current status of insecticide resistance in Q biotype Bemisia tabaci populations from Crete. Pest Manag Sci. 2009 Mar;65(3):313-22. A propoxur-based AChE diagnostic test indicated that iAChE was widespread in most populations. Low resistance levels (RF < 12) were observed for pirimiphos-methyl. |
1(0,0,0,1) | Details |
| 3385133 | Rajini PS, Krishnakumari MK: Toxicity of pirimiphos-methyl: I. J Environ Sci Health B. 1988 Apr;23(2):127-44. Further, significant inhibition of plasma PChE was evident at 250, 500 and 1000 ppm while the degree of inhibition of brain AChE was significant only at the higher dosages. |
1(0,0,0,1) | Details |
| 2600363 | Rajini PS, Muralidhara, Krishnakumari MK: Inhibitory pattern of tissue esterases in rats fed dietary pirimiphos-methyl. J Environ Sci Health B. 1989 Oct;24(5):509-24. Activities of Acetylcholinesterase (AChE) in brain and erythrocytes, pseudocholinesterase (PChE) in plasma and non-specific carboxylesterase (NSE) in brain, liver, plasma and kidney were assayed at weekly intervals in growing male rats fed dietary pirimiphos-methyl at dosages of 1000, and 1500 ppm for a period of 28 days. |
6(0,0,1,1) | Details |
| 10823356 | Szlendak E, Conyers C, Muggleton J, Thind BB: Pirimiphos-methyl resistance in two stored product mites, Acarus siro and Acarus farris, as detected by impregnated paper bioassay and esterase activity assays. Exp Appl Acarol. 2000 Jan;24(1):45-54. |
0(0,0,0,0) | Details |
| 2132992 | Hemingway J, Callaghan A, Amin AM: Mechanisms of organophosphate and resistance in Culex quinquefasciatus from Saudi Arabia. Med Vet Entomol. 1990 Jul;4(3):275-82. There was a significant increase in the amount of Cytochrome P450 in Cx quinquefasciatus lines selected with the pyrethroid permethrin or with the organophosphate pirimiphos-methyl, but no change in lines selected with five other organophosphates or propoxur, compared to the parental strain, which suggests that oxidases are involved in the P450 mediated resistance to both permethrin and pirimiphos-methyl. |
0(0,0,0,0) | Details |
| 1768912 | Bisset JA, Rodriguez MM, Hemingway J, Diaz C, Small GJ, Ortiz E: Malathion and pyrethroid resistance in Culex quinquefasciatus from Cuba: efficacy of pirimiphos-methyl in the presence of at least three resistance mechanisms. Med Vet Entomol. 1991 Apr;5(2):223-8. Use of malathion for mosquito control in Cuba for 7 years up to 1986 has selected for elevated non-specific esterase and altered acetylcholinesterase (AChE) resistance mechanisms in populations of the pest mosquito Culex quinquefasciatus Say. |
1(0,0,0,1) | Details |
| 8551300 | Mazzarri MB, Georghiou GP: Characterization of resistance to organophosphate, and pyrethroid insecticides in field populations of Aedes aegypti from Venezuela. J Am Mosq Control Assoc. 1995 Sep;11(3):315-22. Resistance to the organophosphates (OP) temephos, malathion, and pirimiphos methyl, and the propoxur was found to be low (< 5-fold) in 3 Aedes aegypti populations collected from Falcon and Aragua states of Venezuela. |
0(0,0,0,0) | Details |
| 8723267 | Wirth MC, Georghiou GP: Organophosphate resistance in Culex pipiens from Cyprus. J Am Mosq Control Assoc. 1996 Mar;12(1):112-8. All population samples generally revealed organophosphate resistance to malathion, temephos, chlorpyrifos, fenthion, dichlorvos, and pirimiphos methyl, in decreasing order of magnitude. Resistance was associated with the presence of 5 different overproduced esterases (esterases A1, A2, A5, B2, and B5) as well as an insensitive form of acetylcholinesterase. |
1(0,0,0,1) | Details |
| 18976553 | Pennetier C, Costantini C, Corbel V, Licciardi S, Dabire RK, Lapied B, Chandre F, Hougard JM: Mixture for controlling insecticide-resistant malaria vectors. Emerg Infect Dis. 2008 Nov;14(11):1707-14. During the first 2 weeks posttreatment, the mixture was as effective as deltamethrin alone and was more effective at killing An. gambiae that carried knockdown resistance (kdr) or insensitive acetylcholinesterase resistance (Ace1R) genes. |
1(0,0,0,1) | Details |
| 17615116 | Carter WG, Tarhoni M, Rathbone AJ, Ray DE: Differential protein adduction by seven organophosphorus pesticides in both brain and thymus. Hum Exp Toxicol. 2007 Apr;26(4):347-53. We found significant adduction of partially characterized protein targets in both rat brain and thymus by azamethiphos, chlorfenvinphos, chlorpyrifos-oxon, diazinon-oxon, dichlorvos and malaoxon, in vitro and pirimiphos-methyl in vivo. |
0(0,0,0,0) | Details |
| 8658539 | Marinovich M, Ghilardi F, Galli CL: Effect of pesticide mixtures on in vitro nervous cells: comparison with single pesticides. Toxicology. 1996 Apr 30;108(3):201-6. The toxicity of dimethoate, azinphos-methyl, diazinon, pirimiphos methyl, organophosphorus insecticides, and benomyl (a benzimidazole fungicide) singly and in mixture was studied in a human neuroblastoma cell line, SH-SY5Y. |
0(0,0,0,0) | Details |
| 11107890 | Diaz C, Perez M, Rodriguez MM, Calvo E, Bisset JA, Fresneda M: [Resistance to insecticides in Blattella germanica species strains from Santiago de Cuba]. Rev Cubana Med Trop. 2000 Jan-Apr;52(1):24-30. A study was conducted on the level of resistance to seven insecticides, namely, 3 organophosphate compounds (malathion, chlorpyrifos and pirimiphos-methyl), one (propoxur) and 1 pyrethroid (cypermethrin, deltamethrin and lambdacialotrine) of three field-collected strains of Blattella germanica (Linnaeus, 1767) from Santiago de Cuba. |
0(0,0,0,0) | Details |
| 1527360 | Qureshi MJ, Jamil FF, Haq A, Naqvi SH: Bioavailability and toxicity to rats of bound residues of 14C-pirimiphos-methyl in stored wheat. J Environ Sci Health B. 1992 Aug;27(4):369-75. In a 90-day feeding study, inhibition of plasma cholinesterase and brain acetylcholinesterase strongly suggest that the bound residues possess a toxicological potential. |
1(0,0,0,1) | Details |
| 12061829 | Callaghan A, Fisher TC, Grosso A, Holloway GJ, Crane M: Effect of temperature and pirimiphos methyl on biochemical biomarkers in Chironomus riparius Meigen. Ecotoxicol Environ Saf. 2002 Jun;52(2):128-33. Two biochemical biomarkers, acetylcholinesterase (AChE) and glutathione S-transferase (GST), were measured in individual larvae from each treatment. |
4(0,0,0,4) | Details |
| 10025366 | Gomes J, Dawodu AH, Lloyd O, Revitt DM, Anilal SV: Hepatic injury and disturbed amino acid metabolism in mice following prolonged exposure to organophosphorus pesticides. Hum Exp Toxicol. 1999 Jan;18(1):33-7. Chronic occupational exposure to organophosphorus and -type pesticides significantly inhibits acetylcholinesterase activity and causes morbidity. Laboratory mice were exposed to a formulated mixture of the six organophosphorus pesticides (Dimethoate, Chlorpyrifos, Profenofos, Pirimiphos methyl, Triazophos and Dimethoate) most commonly used in agriculture in this region of the Middle East. |
4(0,0,0,4) | Details |
| 16289700 | Abdel-Halim KY, Salama AK, El-Khateeb EN, Bakry NM: Organophosphorus pollutants (OPP) in aquatic environment at Damietta Governorate, Egypt: implications for monitoring and biomarker responses. Chemosphere. 2006 Jun;63(9):1491-8. Epub 2005 Nov 14. The obtained results are in parallel to that found in case of cholinesterase activity where the activity of both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) was declined at these seasonal period. Chlorpyrifos, chlorpyrifos-methyl, malathion, diazinon, pirimiphos-methyl and profenofos were detected in most samples. |
3(0,0,0,3) | Details |
| 16159111 | Schulze H, Muench SB, Villatte F, Schmid RD, Bachmann TT: Insecticide detection through protein engineering of Nippostrongylus brasiliensis acetylcholinesterase B. Anal Chem. 2005 Sep 15;77(18):5823-30. The detection limit for pirimiphos methyl could be reduced from 10 microg/L to a value as low as 1 ng/L (3.5 x 10 (-)(12) mol/L). |
3(0,0,0,3) | Details |
| 19894225 | Khajehali J, Van Leeuwen T, Grispou M, Morou E, Alout H, Weill M, Tirry L, Vontas J, Tsagkarakou A: Acetylcholinesterase point mutations in European strains of Tetranychus urticae (Acari: Tetranychidae) resistant to organophosphates. Pest Manag Sci. 2010 Feb;66(2):220-8. RESULTS: The resistance ratios of the OP strains varied from 9 to 43 for pirimiphos-methyl, from 78 to 586 for chlorpyrifos, from 8 to 333 for methomyl and from 137 to 4164 for dimethoate. |
2(0,0,0,2) | Details |
| 6193610 | Pellissier C, Leung Tack D, Gras G: [Effect of temephos on acetylcholinesterase activity in the brain of Tilapia guineensis. 3: Comparative effect of temephos and 3 substitute insecticides]. Toxicol Eur Res. 1983 Mar;5(2):63-9. Among these, chlorphoxim, chlorpyrifos-methyl and pirimiphos-methyl proved to be the most effect of these three organophosphorus compounds to that of temephos on the acetylcholinesterasic activity of the brain of Tilapia but using a much higher dosage (0,05 mg/l during 24 hrs that is 144 times more than for temephos). |
2(0,0,0,2) | Details |
| 12946900 | Maycock DS, Prenner MM, Kheir R, Morris S, Callaghan A, Whitehouse P, Morritt D, Crane M: Incorporation of in situ and biomarker assays in higher-tier assessment of the aquatic toxicity of insecticides. Water Res. 2003 Oct;37(17):4180-90. Experimental ponds were dosed with pirimiphos methyl (PM) and lindane. Surviving larvae were analysed for acetylcholinesterase activity (AChE). |
2(0,0,0,2) | Details |
| 18484351 | Tarhoni MH, Lister T, Ray DE, Carter WG: Albumin binding as a potential biomarker of exposure to moderately low levels of organophosphorus pesticides. Biomarkers. 2008 Jun;13(4):343-63. We have evaluated the potential of plasma albumin to provide a sensitive biomarker of exposure to commonly used organophosphorus pesticides in order to complement the widely used measure of acetylcholinesterase (AChE) inhibition. After dosing rats with pirimiphos-methyl (dimethoxy) or chlorfenvinphos (oxon) (diethoxy) pesticides, the resultant albumin binding were still significant 7 days after dosing. |
2(0,0,0,2) | Details |
| 8481527 | Rodriguez M, Ortiz E, Bisset JA, Hemingway J, Saledo E: Changes in malathion and pyrethroid resistance after cypermethrin selection of Culex quinquefasciatus field populations of Cuba. Med Vet Entomol. 1993 Apr;7(2):117-21. Use of the organophosphorus insecticide malathion for mosquito control in Cuba, for 7 years up to 1986, selected elevated non-specific esterase and altered acetylcholinesterase (AChE) resistance mechanisms in Culex quinquefasciatus. In the central Havana region, pirimiphos-methyl, an organophosphorus insecticide unaffected by the two common malathion resistance mechanisms, is now being used in a resistance management strategy designed to avoid pyrethroid resistance spreading. |
2(0,0,0,2) | Details |
| 15747116 | Del Carlo M, Pepe A, Mascini M, De Gregorio M, Visconti A, Compagnone D: Determining pirimiphos-methyl in durum wheat samples using an acetylcholinesterase inhibition assay. Anal Bioanal Chem. 2005 Apr;381(7):1367-72. Epub 2005 Mar 4. The procedure for the oxidation of pirimiphos methyl via N-bromosuccinimide (NBS) and AChE inhibition was optimised for reagent concentrations and inhibition time in a buffer solution. |
175(1,4,4,5) | Details |
| 17710279 | Dzul FA, Patricia Penilla R, Rodriguez AD: [Susceptibility and insecticide resistance mechanisms in Anopheles albimanus from the southern Yucatan Peninsula, Mexico]. Salud Publica Mex. 2007 Jul-Aug;49(4):302-11. The altered AChE was the mechanism correlated to pirimiphos-methyl resistance in La Union. |
82(1,1,1,2) | Details |