Protein Information

Name neurotoxic esterase
Synonyms NTE; SWS; Neuropathy target esterase; Neurotoxic esterase; PNPLA 6; patatin like phospholipase domain containing 6; Neuropathy target esterases…

Compound Information

Name trichlorfon
CAS

Reference List

PubMed Abstract RScore(About this table)
10509429 Abdelsalam EB: Neurotoxic potential of six organophosphorus compounds in adult hens. Vet Hum Toxicol. 1999 Oct;41(5):290-2.

The neurotoxic potential of trichlorfon, diazinon, phosmet, dichlorvos, phosphamidon and coumaphos was evaluated for their ability to inhibit brain neurotoxic esterase (NTE) activity in adult hens.
81(1,1,1,1) Details
7344417 Johnson MK: Delayed neurotoxicity - do trichlorphon and/or dichlorvos cause delayed neuropathy in man or in test animals?. Acta Pharmacol Toxicol. 1981;49 Suppl 5:87-98.


In hens double doses of trichlorphon each exceeding unprotected LD50 can produce moderate neuropathy associated with appropriately high inhibitions of neurotoxic esterase.
3(0,0,0,3) Details
7199685 Olajos EJ, Rosenblum I: Membrane-bound and soluble esterase activities in various hen brain regions after diisopropyl phosphorofluoridate and trichlorfon treatment. Neurotoxicology. 1981 Nov;2(3):463-70.

Acetylcholinesterase, neurotoxic esterase, and nonspecific esterase activities were studied in subcellular fractions obtained from homogenates of forebrain, cerebellum, and brainstem areas of hen brain.
3(0,0,0,3) Details
9823777 Tian Y, Xie XK, Piao FY, Yamauchi T: Delayed neuropathy and inhibition of soluble neuropathy target esterase following the administration of organophosphorus compounds to hens. Tohoku J Exp Med. 1998 Jul;185(3):161-71.

2(0,0,0,2) Details
9268605 Ehrich M, Correll L, Veronesi B: Acetylcholinesterase and neuropathy target esterase inhibitions in neuroblastoma cells to distinguish organophosphorus compounds causing acute and delayed neurotoxicity. Fundam Appl Toxicol. 1997 Jul;38(1):55-63.

Inhibition of AChE was greater than inhibition of NTE, without overlap of the concentration-response curves, for OPs which are more likely to cause acute, rather than delayed, neurotoxic effects in vivo (e.g., chlorpyrifos-oxon, dichlorvos, and trichlorfon).
2(0,0,0,2) Details
12425964 Honorato de Oliveira G, Moreira V, Ribeiro Goes SP: Organophosphate induced delayed neuropathy in genetically dissimilar chickens: studies with tri-ortho-cresyl phosphate (TOCP) and trichlorfon. Toxicol Lett. 2002 Dec 15;136(2):143-50.

Measurements of plasma cholinesterase (pl.ChE), brain cholinesterase (Br.ChE) and brain Neuropathy Target Esterase (Br.NTE) were made in three different lineages of chickens.
1(0,0,0,1) Details
10706244 Huggins DJ, Richardson RJ: Brainstem axolemmal protein phosphorylation in vitro in hens dosed with di-1-butyl-2,2-dichlorovinyl phosphate. J Toxicol Environ Health A. 1999 Feb 26;56(4):263-82.


Neuropathy target esterase (neurotoxic esterase, NTE), a protein thought to be involved in the production of organophosphorus compound-induced delayed neurotoxicity (OPIDN), has been postulated to be a component of endogenous neuronal protein phosphorylation systems.
1(0,0,0,1) Details
6733596 Slott V, Ecobichon DJ: An acute and subacute neurotoxicity assessment of trichlorfon. . Can J Physiol Pharmacol. 1984 May;62(5):513-8.

At 24 h posttreatment, the birds were observed for visible signs of neurotoxicity, were euthanized, and samples of blood plasma, brain, and spinal cord (cervical and thoracic regions) were obtained for quantification of cholinesterase and neurotoxic esterase (NTE) activities.
1(0,0,0,1) Details
9513919 Xie X, Piao FY, Tian Y, Yamauchi T: Pharmacokinetics and neurotoxicity of dipterex in hens. J Toxicol Sci. 1998 Feb;23(1):25-33.


We compared the tissue concentration of dipterex and the inhibition of the neuropathy target esterase (NTE) activity among groups of hens (n = 8 each) which were intravenously (i.v.), subcutaneously (s.c.) or orally (p.o.) administered the insecticide dipterex.
1(0,0,0,1) Details
16042503 Lotti M, Moretto A: Organophosphate-induced delayed polyneuropathy. . Toxicol Rev. 2005;24(1):37-49.

Neuropathy target esterase (NTE) is thought to be the target of OPIDP initiation.
In this article, we mainly discuss OP pesticide poisoning, particularly when caused by chlorpyrifos, dichlorvos, isofenphos, methamidophos, mipafox, trichlorfon, trichlornat, phosphamidon/mevinphos and by certain carbamates.
1(0,0,0,1) Details
8065512 Mehl A, Schanke TM, Johnsen BA, Fonnum F: The effect of trichlorfon and other organophosphates on prenatal brain development in the guinea pig. Neurochem Res. 1994 May;19(5):569-74.

0(0,0,0,0) Details