| Name | glutathione S transferase |
|---|---|
| Synonyms | GST class alpha 2; Gst2; GST class alpha; GST class alpha member 2; GST gamma; GSTA 2; GSTA2; GSTA2 2… |
| Name | lindane |
|---|---|
| CAS | (1α,2α,3β,4α,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11758396 | Yin D, Jin H, Yu H, Chen L: [A comparative study on the sensitivity and specificity of cholinesterase and glutathione s-transferase in Gammarus pulex L.]. Ying Yong Sheng Tai Xue Bao. 2001 Aug;12(4):615-8. Studies on the influences of lindane, pirimiphos methyl, permethrin, zinc and dodecyl linear alkybenzene sulfonate (LAS) on the activity and toxicity of cholinesterase (ChE) and glutathione s-transferase (GST) in Gammarus pulex L. showed that only pirimiphos methyl caused a change in ChE activity in Gammarus, with a significant reduction in enzyme activity after 24 h and 48 h exposure. |
32(0,1,1,2) | Details |
| 8703089 | Syvanen M, Zhou Z, Wharton J, Goldsbury C, Clark A: Heterogeneity of the glutathione transferase genes encoding enzymes responsible for insecticide degradation in the housefly. J Mol Evol. 1996 Sep;43(3):236-40. One of the four glutathione-S-transferases (GST) that is overproduced in the insecticide-resistant Cornell-R strain of the housefly (Musca domestica) produces an activity that degrades the insecticide dimethyl parathion and conjugates to lindane. |
31(0,1,1,1) | Details |
| 18389491 | Ahmed RS, Suke SG, Seth V, Chakraborti A, Tripathi AK, Banerjee BD: Protective effects of dietary ginger (Zingiber officinales Rosc.) on lindane-induced oxidative stress in rats. Phytother Res. 2008 Jul;22(7):902-6. Concomitant dietary feeding of ginger (1%w/w) significantly attenuated lindane-induced lipid peroxidation, accompanied by modulation of OFR scavenging enzymes as well as (GSH) and the GSH dependent enzymes peroxidase (Gpx), glutathione reductase (GR) and glutathione-S-transferase (GST) in these rats. |
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| 15620088 | Sheweita SA: Carcinogen-metabolizing enzymes and insecticides. J Environ Sci Health B. 2004;39(5-6):805-18. In addition, the activity of glutathione S-transferase (GST), glutathione reductase (GR), and the level of (GSH) were determined in the liver of male mice after oral administration of sumithion, dursban, chlordane, methoxychlor, heptachlor epoxide, and lindane as single (24h) or as repeated doses for six consecutive days. |
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| 7692623 | Junqueira VB, Barros SB, Simizu K, Fernandez V, Carrion Y, Pimentel R, Azzalis LA, Videla LA: Turnover of hepatic after acute lindane intoxication. Toxicol Lett. 1993 Aug;69(2):211-6. At these experimental times, the activities of peroxidase, glutathione reductase, glutathione-S-transferases and gamma-glutamyltransferase in the liver of lindane-treated rats and control animals were comparable. |
6(0,0,1,1) | Details |
| 11583927 | Wei SH, Clark AG, Syvanen M: Identification and cloning of a key insecticide-metabolizing glutathione S-transferase (MdGST-6A) from a hyper insecticide-resistant strain of the housefly Musca domestica. Insect Biochem Mol Biol. 2001 Nov 1;31(12):1145-53. When expressed in Escherichia coli, one of the cloned GSTs, MdGST-6A, produces an enzyme that conjugates to the insecticides methyl parathion and lindane. |
2(0,0,0,2) | Details |
| 12487730 | Garcia-Fernandez AJ, Bayoumi AE, Perez-Pertejo Y, Romero D, Ordonez C, Reguera RM, Balana-Fouce R, Ordonez D: Changes in -redox balance induced by hexachlorocyclohexane and lindane in CHO-K1 cells. Xenobiotica. 2002 Nov;32(11):1007-16. The -redox cycle enzymes peroxidase, glutathione reductase and glutathione S-transferase, and total and were evaluated at several points during the standard growth curve of the cultures. 2. |
1(0,0,0,1) | Details |
| 11165752 | Masuda C, Wanibuchi H, Otori K, Wei M, Yamamoto S, Hiroi T, Imaoka S, Funae Y, Fukushima S: Presence of a no-observed effect level for enhancing effects of development of the alpha-isomer of benzene hexachloride (alpha-BHC) on diethylnitrosamine-initiated hepatic foci in rats. Cancer Lett. 2001 Feb 26;163(2):179-85. All surviving animals were killed at week 8, and their livers were examined immunohistochemically for detection of glutathione S-transferase placental form (GST-P)-positive foci, surrogate preneoplastic lesions. |
1(0,0,0,1) | Details |
| 18941829 | Sole M, Hambach B, Cortijo V, Huertas D, Fernandez P, Company JB: Muscular and hepatic pollution biomarkers in the fishes Phycis blennoides and Micromesistius poutassou and the crustacean Aristeus antennatus in the Blanes Submarine Canyon (NW Mediterranean). Arch Environ Contam Toxicol. 2009 Jul;57(1):123-32. Epub 2008 Oct 22. Several pollution biomarkers in muscle (activity of cholinesterases) and liver/hepatopancreas (catalase, glutathione S-transferases, carboxylesterases, ethoxyresorufin O-deethylase in fish or mixed function oxygenase (MFO)-related reductases in crustacean, and lipid peroxidation levels) were measured. |
1(0,0,0,1) | Details |
| 16156589 | Kristensen M: Glutathione S-transferase and insecticide resistance in laboratory strains and field populations of Musca domestica. J Econ Entomol. 2005 Aug;98(4):1341-8. Three laboratory strains selected by tetrachlorvinphos, lindane (gamma-HCH) and dimethoate, respectively, had significantly elevated CDNB- and DCNB-GST activities. |
2(0,0,0,2) | Details |
| 8882386 | Descampiaux B, Leroux JM, Peucelle C, Erb F: Assay of free-radical toxicity and antioxidant effect on the Hep 3B cell line: a test survey using lindane. Cell Biol Toxicol. 1996 Feb;12(1):19-28. The content of and of as well as the activities of glutathione reductase, peroxidase, glutathione S-transferases, catalase and superoxide dismutases were determined in human hepatoma Hep 3B cells in relation to free-radical toxicity in order to appreciate the defense capacities of these cells compared to data on normal hepatocytes. |
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| 18940228 | Anilakumar KR, Saritha V, Khanum F, Bawa AS: Ameliorative effect of ajwain extract on hexachlorocyclohexane-induced lipid peroxidation in rat liver. Food Chem Toxicol. 2009 Feb;47(2):279-82. Epub 2008 Oct 4. Prefeeding of ajwain extract resulted in decreased hepatic levels of lipid peroxides and increased GSH, GSH-peroxidase, G-6-PDH, SOD, catalase and glutathione S-transferase (GST) activities. |
1(0,0,0,1) | Details |
| 17761640 | Trivedi NP, Rawal UM, Patel BP: Hepatoprotective effect of andrographolide against hexachlorocyclohexane-induced oxidative injury. Integr Cancer Ther. 2007 Sep;6(3):271-80. (GSH), glutathione-s-transferase (GST), glutathione reductase (GR), peroxidase (GSH-Px), gamma-glutamyl transpeptidase (gamma-GTP), superoxide dismutase (SOD), catalase (CAT), and lipid peroxidation (LPO) are studied by spectrophotometric methods. |
1(0,0,0,1) | Details |
| 8584504 | Puri S, Kohli KK: Differences in hepatic drug metabolizing enzymes and their response to lindane in rat, rabbit and monkey. Pharmacol Toxicol. 1995 Aug;77(2):136-41. The activity of glutathione-S-transferase towards 1-chloro-2,4-dinitrobenzene and the band intensity of 26 KDa polypeptide was found to be at maximum in untreated rabbits, while rat liver demonstrated the highest activity of glutathione-S-transferase towards ethacrynic acid. |
1(0,0,0,1) | Details |
| 16834997 | Rocher B, Le Goff J, Peluhet L, Briand M, Manduzio H, Gallois J, Devier MH, Geffard O, Gricourt L, Augagneur S, Budzinski H, Pottier D, Andre V, Lebailly P, Cachot J: Genotoxicant accumulation and cellular defence activation in bivalves chronically exposed to waterborne contaminants from the Seine River. Aquat Toxicol. 2006 Aug 12;79(1):65-77. Epub 2006 Jun 2. The study focused on polyaromatic hydrocarbons (PAH), lindane, polychlorobiphenyls (PCB) and metals known to be potential genotoxicants and/or reactive species (ROS) inducers. Enzymatic activities related to cellular defence systems including the phase II enzyme glutathione S-transferase (GST) and three antioxidant enzymes superoxide dismutase (SOD), catalase (CAT) and peroxidase (GPx) were measured in gills. |
1(0,0,0,1) | Details |
| 17123163 | Anilakumar KR, Khanum F, Santhanam K: Amelioration of hexachlorocyclohexane-induced oxidative stress by amaranth leaves in rats. Plant Foods Hum Nutr. 2006 Dec;61(4):169-73. The significant reduction in the level of glutathione S-transferase brought about by HCH was restored to control level by feeding 20% AL. |
1(0,0,0,1) | Details |
| 16838206 | Wang F, Xu ZR, Sun JH: Effect of HCH contamination of diet on the growth performance and immune and antioxidant ability in growing/finishing pigs. Vet Res Commun. 2006 Aug;30(6):645-54. Addition of HCH to feedstuff reduced superoxide dismutase (SOD), glutathione S-transferase (GST), glutathione reductase (GR) and peroxidase (GSH-Px) activities in liver, reduced serum catalase (CAT) activity, and increased serum malondialehyde (MDA). |
1(0,0,0,1) | Details |
| 15382504 | Kristensen M, Jespersen JB, Knorr M: Cross-resistance potential of fipronil in Musca domestica. Pest Manag Sci. 2004 Sep;60(9):894-900. Biochemical assays of esterase, glutathione S-transferase and cytochrome P450 monooxygenase indicated that the low fipronil resistance observed in laboratory and field strains could be caused by elevated detoxification or be due to a target-site resistance mechanism with cross-resistance to gamma-HCH. |
1(0,0,0,1) | Details |
| 11166672 | Anguiano OL, Caballero de Castro A, Pechen de D'Angelo AM: The role of conjugation in the regulation of early toad embryos' tolerance to pesticides. Comp Biochem Physiol C Toxicol Pharmacol. 2001 Jan;128(1):35-43. Reduced (GSH) content and glutathione S-transferase (GSH S-transferase) activity were investigated in developing toad embryos exposed to parathion, malathion, lindane and dieldrin. |
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| 16257038 | Romeo M, Gharbi-Bouraoui S, Gnassia-Barelli M, Dellali M, Aissa P: Responses of Hexaplex (Murex) trunculus to selected pollutants. Sci Total Environ. 2006 Apr 15;359(1-3):135-44. Epub 2005 Oct 27. An evaluation of the biological effects of the most toxic metals (cadmium and and of two organics (carbofuran and lindane), present in the sediments of the Bizerta lagoon, was attempted by measuring biomarkers (acetylcholinesterase: AChE, catalase: CAT and glutathione S-transferase: GST activities) in animals experimentally exposed for 48 or 72 h. |
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| 10817630 | Videla LA, Arisi AC, Fuzaro AP, Koch OR, Junqueira VB: Prolonged phenobarbital pretreatment abolishes the early oxidative stress component induced in the liver by acute lindane intoxication. Toxicol Lett. 2000 Apr 10;115(1):45-51. These changes were observed in the absence of changes in either microsomal functions (cytochrome P450 content, -dependent production, and NADPH-cytochrome P450 reductase or oxidase activities) or in oxidative stress-related enzymatic activities (superoxide dismutase, catalase, peroxidase, glutathione reductase, glucose-6-phosphate dehydrogenase, and glutathione-S-transferases), over control values. |
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| 16046044 | Srivastava A, Shivanandappa T: Hexachlorocyclohexane differentially alters the antioxidant status of the brain regions in rat. Toxicology. 2005 Oct 15;214(1-2):123-30. Activities of peroxidase, glutathione reductase, glutathione-S-transferase and catalase were markedly induced whereas superoxide dismutase was inhibited at higher dose in all the brain regions. |
1(0,0,0,1) | Details |
| 9515900 | Miyauchi K, Suh SK, Nagata Y, Takagi M: Cloning and sequencing of a 2,5-dichlorohydroquinone reductive dehalogenase gene whose product is involved in degradation of gamma-hexachlorocyclohexane by Sphingomonas paucimobilis. J Bacteriol. 1998 Mar;180(6):1354-9. The linD gene encodes a peptide of 343 amino acids and has a low level of similarity to proteins which belong to the glutathione S-transferase family. |
1(0,0,0,1) | Details |
| 11349524 | Trivedi NP, Rawal UM: Hepatoprotective and antioxidant property of Andrographis paniculata (Nees) in BHC induced liver damage in mice. Indian J Exp Biol. 2001 Jan;39(1):41-6. Andrographis paniculata (AP) treatment prevents BHC induced increase in the activities of enzymes y-Glutamyl transpeptidase, glutathione-S-transferase and lipid peroxidation. |
1(0,0,0,1) | Details |
| 10414779 | Banerjee BD, Seth V, Bhattacharya A, Pasha ST, Chakraborty AK: Biochemical effects of some pesticides on lipid peroxidation and free-radical scavengers. Toxicol Lett. 1999 Jun 30;107(1-3):33-47. Oxidative stress was studied in blood samples obtained from lindane, malathion and propoxur poisoning cases admitted to the Guru Teg Bahadur Hospital, Delhi and evaluated for lipid peroxidation, free radical (OFR) scavenging enzymes, and (GSH) and related enzymes. The level of thiobarbituric acid reacting substances and activities of superoxide dismutase, catalase, peroxidase, glutathione-S-transferase and GGT were increased and GSH level was decreased in pesticide poisoning. |
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| 16246485 | Puatanachokchai R, Morimura K, Wanibuchi H, Oka M, Kinoshita A, Mitsuru F, Yamaguchi S, Funae Y, Fukushima S: Alpha-benzene hexachloride exerts hormesis in preneoplastic lesion formation of rat hepatocarcinogenesis with the possible role for hepatic detoxifying enzymes. Cancer Lett. 2006 Aug 18;240(1):102-13. Epub 2005 Oct 24. The highest concentration of alpha-BHC significantly increased the number and area of glutathione S-transferase placental form (GST-P) positive foci, preneoplastic lesions in the liver, but its low dose, 0.05 ppm, caused significant reduction, showing a J-shape dose-response curve. |
1(0,0,0,1) | Details |
| 1283138 | Joseph P, Shivanandappa T, Narasimhamurthy K, Krishnakumari MK: Effect of on hexachlorocyclohexane (HCH) toxicity in the rat. Gen Pharmacol. 1992 Nov;23(6):1159-64. The activities of the hepatic xenobiotic metabolizing enzymes were generally low (with the exception of glutathione S-transferase) in the -deficient rats compared to those of the supplemented diet groups. 5. |
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| 7683635 | Tsuda H, Matsumoto K, Ogino H, Ito M, Hirono I, Nagao M, Sato K, Cabral R, Bartsch H: Demonstration of initiation potential of carcinogens by induction of preneoplastic glutathione S-transferase P-form-positive liver cell foci: possible in vivo assay system for environmental carcinogens. Jpn J Cancer Res. 1993 Mar;84(3):230-6. Initiating potential was assayed on the basis of significant increase in values of preneoplastic placental form glutathione S-transferase-positive (GST-P+) foci of more than 3 cells in cross section at week 10. |
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| 11482645 | Hirthe G, Fisher TC, Crane M, Callaghan A: Short-term exposure to sub-lethal doses of lindane affects developmental parameters in Chironomus riparius Meigen, but has no effect on larval glutathione-S-transferase activity. Chemosphere. 2001 Aug;44(4):583-9. |
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| 20182699 | Sharma P, Singh R: Protective Role of on Lindane Induced Reproductive Toxicity in Male Wistar Rats. Bull Environ Contam Toxicol. 2010 Feb 25. |
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