11467929 |
Liao DI, Thompson JE, Fahnestock S, Valent B, Jordan DB: A structural account of substrate and inhibitor specificity differences between two naphthol reductases. Biochemistry. 2001 Jul 31;40(30):8696-704.
Two short chain dehydrogenase/reductases mediate naphthol reduction reactions in fungal melanin biosynthesis. An X-ray structure of 1,3,6,8-tetrahydroxynaphthalene reductase (4HNR) complexed with NADPH and pyroquilon was determined for examining substrate and inhibitor specificities that differ from those of 1,3,8-trihydroxynaphthalene reductase (3HNR). |
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