| Name | CYP3A |
|---|---|
| Synonyms | CP33; CYP3; HLP; CYP3A; CP34; CYP 3A4; CYP 3; CYP3A3… |
| Name | ethoxyquin |
|---|---|
| CAS | 6-ethoxy-1,2-dihydro-2,2,4-trimethylquinoline |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12011477 | Johnson DR, Klaassen CD: Regulation of rat multidrug resistance protein 2 by classes of prototypical microsomal enzyme inducers that activate distinct transcription pathways. Toxicol Sci. 2002 Jun;67(2):182-9. Mrp2 protein levels were significantly increased by all 3 PXR ligands/CYP3A inducers -16alpha-carbonitrile [PCN], spironolactone [SP], and dexamethasone [DEX]) and by both ARE/EpRE ligands (ethoxyquin [EQ] and oltipraz [OPZ]). |
33(0,1,1,3) | Details |
| 16790489 | Berdikova Bohne VJ, Hamre K, Arukwe A: Hepatic biotransformation and metabolite profile during a 2-week depuration period in Atlantic salmon fed graded levels of the synthetic antioxidant, ethoxyquin. Toxicol Sci. 2006 Sep;93(1):11-21. Epub 2006 Jun 21. Consumption of dietary EQ produced the expression of CYP3A, glutathione S-transferase (GST), and glucuronosyl-transferase (UDPGT) mRNA during the depuration period. |
4(0,0,0,4) | Details |
| 17150295 | Berdikova Bohne VJ, Hamre K, Arukwe A: Hepatic metabolism, phase I and II biotransformation enzymes in Atlantic salmon (Salmo Salar, L) during a 12 week feeding period with graded levels of the synthetic antioxidant, ethoxyquin. Food Chem Toxicol. 2007 May;45(5):733-46. Epub 2006 Nov 10. However, the decrease in biotransformation rate results in the accumulation of EQ metabolites, high concentration of which was postulated to alter translation and post-translational modification of CYP3A, GST and UDPGT at feeding day 14 and 42, with subsequent decreases in the biotransformation of consumed EQ. |
1(0,0,0,1) | Details |
| 11294974 | Sanders JM, Burka LT, Chanas B, Matthews HB: Comparative xenobiotic metabolism between Tg.AC and p53+/- genetically altered mice and their respective wild types. Toxicol Sci. 2001 May;61(1):54-61. The present work tests the generally held assumption that xenobiotic metabolism in the TG:AC and p53+/- mouse is not inherently different from that of the respective wild type, the FVB/N and C57BL/6 mouse, by comparing each genotype's ability to metabolize ethoxyquin, or methacrylonitrile. Further, expression of CYP1A2, CYP2E1, CYP3A, and GST-alpha in liver of naive genetically altered mice was similar to that of corresponding wild-type mice. |
1(0,0,0,1) | Details |