Protein Information

Name clusterin
Synonyms AAG 4; TRPM2; AAG4; APOJ; Apo J; Apolipoprotein J; CLI; CLU…

Compound Information

Name MAA
CAS methylarsonic acid

Reference List

PubMed Abstract RScore(About this table)
14656996 Barone F, Aguanno S, D'Alessio A, D'Agostino A: Sertoli cell modulates MAA-induced apoptosis of germ cells throughout voltage-operated calcium channels. FASEB J. 2004 Feb;18(2):353-4. Epub 2003 Dec 4.


In this paper, we have used clusterin expression as an indicator of germ cell apoptosis in rat seminiferous tubules treated with MAA in the presence or in the absence of voltage-operated calcium channels (VOCCs) inhibitors.
2(0,0,0,2) Details
9314588 Clark AM, Maguire SM, Griswold MD: Accumulation of clusterin/sulfated glycoprotein-2 in degenerating pachytene spermatocytes of adult rats treated with methoxyacetic acid. Biol Reprod. 1997 Oct;57(4):837-46.

7(0,0,0,7) Details
16002543 Plotton I, Sanchez P, Perrard MH, Durand P, Lejeune H: Quantification of stem cell factor mRNA levels in the rat testis: usefulness of clusterin mRNA as a marker of the amount of mRNA of Sertoli cell origin in post pubertal rats. J Endocrinol. 2005 Jul;186(1):131-43.

6(0,0,0,6) Details
11906924 Bailey RW, Aronow B, Harmony JA, Griswold MD: Heat shock-initiated apoptosis is accelerated and removal of damaged cells is delayed in the testis of clusterin/ApoJ knock-out mice. Biol Reprod. 2002 Apr;66(4):1042-53.

6(0,0,0,6) Details
15840169 Barone F, Aguanno S, D'Agostino A: Modulation of MAA-induced apoptosis in male germ cells: role of Sertoli cell P/Q-type calcium channels. Reprod Biol Endocrinol. 2005 Apr 19;3:13.


In this paper we have used the protein clusterin, produced by Sertoli cells and associated with tissue damage or injury, as indicator of germ cell apoptosis in rat seminiferous tubules treated with MAA in the presence or in the absence of omega-agatoxin, a specific inhibitor of P/Q type voltage-operated calcium channels (VOCC's).
2(0,0,0,2) Details