| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | MAA |
|---|---|
| CAS | methylarsonic acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 6235789 | Sugiyama S, Satoh T, Uzalp B, Ueno K, Igarashi T, Kitagawa H: Effects of a single administration of 6-aminonicotinamide on hepatic microsomal drug metabolism in rats. Arch Int Pharmacodyn Ther. 1984 May;269(1):20-33. Of the first two steps of AM metabolism mediated by cytochrome P-450-coupled monooxygenase, the second step (from MAA to MA) was found to be more affected by 6-AN than the first one (from AM to MAA). |
81(1,1,1,1) | Details |
| 2440440 | Slusher LB, Park SS, Gelboin HV, Vesell ES: Studies on the metabolism of aminopyrine, antipyrine and using monoclonal antibodies to cytochrome P-450 isozymes purified from rat liver. Biochem Pharmacol. 1987 Jul 15;36(14):2359-67. |
3(0,0,0,3) | Details |
| 3415241 | Imaoka S, Inoue K, Funae Y: Aminopyrine metabolism by multiple forms of cytochrome P-450 from rat liver microsomes: simultaneous quantitation of four aminopyrine metabolites by high-performance liquid chromatography. Arch Biochem Biophys. 1988 Aug 15;265(1):159-70. |
2(0,0,0,2) | Details |
| 10945659 | Comings DE, Gade-Andavolu R, Gonzalez N, Wu S, Muhleman D, Blake H, Chiu F, Wang E, Farwell K, Darakjy S, Baker R, Dietz G, Saucier G, MacMurray JP: Multivariate analysis of associations of 42 genes in ADHD, ODD and conduct disorder. Clin Genet. 2000 Jul;58(1):31-40. In contrast to ADHD and ODD, CD preferentially utilized hormone and neuropeptide genes These included CCK, CYP19 (aromatase cytochrome P-450), ESR1, and INS (p = 0.005). |
1(0,0,0,1) | Details |
| 12678737 | Leu TH, Maa MC: The molecular mechanisms for the antitumorigenic effect of . Curr Med Chem Anticancer Agents. 2002 May;2(3):357-70. These included the aryl hydrocarbon receptor, cytochrome P450, glutathione S-transferase, serine/threonine kinases, transcription factors, cyclooxygenase, ornithine decarboxylase, synthase, matrix metalloproteinases and kinases. |
1(0,0,0,1) | Details |
| 2872706 | Hoshi K, Senda N, Igarashi T, Satoh T, Ueno K, Kitagawa H: Effects of co-administration of monomethylaminoantipyrine with diethylaminoethyl 2,2-diphenylvalerate (SKF 525-A) on gamma-glutamyltranspeptidase, glutathione S-transferase and hepatic drug metabolizing enzyme activities in rats. Res Commun Chem Pathol Pharmacol. 1986 Apr;52(1):71-80. 4-Monomethylaminoantipyrine (MAA)-induced increase of hepatic drug metabolizing enzymes was suppressed by SKF 525-A. This may be due to the partial binding of SKF 525-A to a portion of cytochrome P-450. |
1(0,0,0,1) | Details |
| 2706012 | Loft S, Poulsen HE: Metabolism of metronidazole and antipyrine in isolated rat hepatocytes. Biochem Pharmacol. 1989 Apr 1;38(7):1125-36. The results suggest that the formation of MAA, HM, HMAP, NORAP and OHAP from metronidazole and antipyrine is catalyzed by different cytochrome P-450 isozymes, which may be supplemented or substituted by PB or MC induced species. |
1(0,0,0,1) | Details |
| 15871691 | Toh YC, Ng S, Khong YM, Samper V, Yu H: A configurable three-dimensional microenvironment in a microfluidic channel for primary hepatocyte culture. Assay Drug Dev Technol. 2005 Apr;3(2):169-76. Primary rat hepatocytes cultured for 24 h in the 3D matrix within the microchannel showed comparable or enhanced cytochrome P450 7-ethoxyresorufin-O-deethylation activity with static controls. |
1(0,0,0,1) | Details |
| 6668542 | Matsuyama K, Noda A, Goto S, Tanaka T, Iguchi S: Influence of phenobarbital and 3-methylcholanthrene on the metabolism of aminopyrine in isolated hepatocyte system. J Pharmacobiodyn. 1983 Nov;6(11):821-8. Present observation suggests the participation of cytochrome P-448 as well as cytochrome P-450 in the metabolism of AM. |
1(0,0,0,1) | Details |