| Name | p38 |
|---|---|
| Synonyms | AIMP 2; p38; AIMP2; JTV 1; JTV1; JTV1 gene; JTV1 protein; Multisynthetase complex auxiliary component p38… |
| Name | sodium arsenite |
|---|---|
| CAS | sodium arsenenite |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9671412 | Lim CP, Jain N, Cao X: Stress-induced immediate-early gene, egr-1, involves activation of p38/JNK1. Oncogene. 1998 Jun 4;16(22):2915-26. Here we report that in NIH3T3 cells, egr-1 is induced by various stress treatments such as heat shock, sodium arsenite, ultraviolet (U.V.) radiation, and anisomycin. p38 and JNK1, but not ERK2, were activated by these stress treatments. |
4(0,0,0,4) | Details |
| 11698504 | Werz O, Klemm J, Radmark O, Samuelsson B: p38 MAP kinase mediates stress-induced leukotriene synthesis in a human B-lymphocyte cell line. J Leukoc Biol. 2001 Nov;70(5):830-8. Here we demonstrate that several stimuli of cell stress such as osmotic shock NaCl), oxidative stress peroxide, diamide), chemical stress sodium arsenite, and inflammatory cytokines enhanced cellular 5-LO activity in a B cell line (BL41-E95-A), when added simultaneously with ionophore plus |
4(0,0,0,4) | Details |
| 12637567 | Kietzmann T, Samoylenko A, Immenschuh S: Transcriptional regulation of heme oxygenase-1 gene expression by MAP kinases of the JNK and p38 pathways in primary cultures of rat hepatocytes. J Biol Chem. 2003 May 16;278(20):17927-36. Epub 2003 Mar 11. Heme oxygenase-1 (HO-1) gene expression is induced by various oxidative stress stimuli including sodium arsenite. |
4(0,0,0,4) | Details |
| 11446828 | Namgung U, Xia Z: Arsenic induces apoptosis in rat cerebellar neurons via activation of JNK3 and p38 MAP kinases. Toxicol Appl Pharmacol. 2001 Jul 15;174(2):130-8. Exposure to 5, 10, or 15 microM sodium arsenite reduced cerebellar neuron viability and induced nuclear fragmentation and condensation as well as DNA degradation to oligonucleosome fragments. |
3(0,0,0,3) | Details |
| 19082730 | Chowdhury R, Chowdhury S, Roychoudhury P, Mandal C, Chaudhuri K: Arsenic induced apoptosis in malignant melanoma cells is enhanced by through ROS generation, p38 signaling and p53 activation. Apoptosis. 2009 Jan;14(1):108-23. |
3(0,0,0,3) | Details |
| 11312036 | Son MH, Kang KW, Lee CH, Kim SG: Potentiation of arsenic-induced cytotoxicity by amino acid deprivation (SAAD) through activation of ERK1/2, p38 kinase and JNK1: the distinct role of JNK1 in SAAD-potentiated mercury toxicity. Toxicol Lett. 2001 Apr 8;121(1):45-55. Viability was assessed in H4IIE cells treated with sodium arsenite, mercuric selenite, lead trioxide or |
3(0,0,0,3) | Details |
| 11807011 | Werz O, Burkert E, Samuelsson B, Radmark O, Steinhilber D: Activation of 5-lipoxygenase by cell stress is independent in human polymorphonuclear leukocytes. Blood. 2002 Feb 1;99(3):1044-52. This study showed that various forms of cell stress, such as chemical stress (sodium arsenite), osmotic stress, or heat shock lead to substantial formation of 5-LO products in freshly isolated human polymorphonuclear leukocytes (PMNLs), when exogenous (10 microM) was present. In parallel, cell stress led to activation of p38 MAPK (mitogen-activated protein kinase) and mitogen-activated protein kinase-activated protein kinases (MAPKAPKs) kinases, which can phosphorylate 5-LO in vitro. |
3(0,0,0,3) | Details |
| 10944112 | Goh KC, deVeer MJ, Williams BR: The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin. EMBO J. 2000 Aug 15;19(16):4292-7. |
3(0,0,0,3) | Details |
| 11278616 | Kayyali US, Donaldson C, Huang H, Abdelnour R, Hassoun PM: Phosphorylation of xanthine dehydrogenase/oxidase in hypoxia. . J Biol Chem. 2001 Apr 27;276(17):14359-65. Epub 2001 Jan 22. XDH/XO phosphorylation appears to be mediated, at least in part, by casein kinase II and p38 kinase as inhibitors of these kinases partially prevent XDH/XO phosphorylation. |
3(0,0,0,3) | Details |
| 12639917 | Vandeput F, Perpete S, Coulonval K, Lamy F, Dumont JE: Role of the different mitogen-activated protein kinase subfamilies in the stimulation of dog and human thyroid epithelial cell proliferation by cyclic 5'-monophosphate and growth factors. Endocrinology. 2003 Apr;144(4):1341-9. ERKs, c-Jun N-terminal kinases (JNKs), and p38 MAPK in the proliferation of dog and human thyroid epithelial cells (thyrocytes) in primary cultures. |
2(0,0,0,2) | Details |
| 15056798 | Trouba KJ, Germolec DR: Micromolar concentrations of sodium arsenite induce cyclooxygenase-2 expression and stimulate p42/44 mitogen-activated protein kinase phosphorylation in normal human epidermal keratinocytes. Toxicol Sci. 2004 Jun;79(2):248-57. Epub 2004 Mar 31. Inhibitors of p42/44 and p38 MAPKs were used to evaluate the contribution of mitogen and stress signaling to the modulation of COX-2. |
2(0,0,0,2) | Details |
| 11325585 | Chevalier D, Thorin E, Allen BG: Simultaneous measurement of ERK, p38, and JNK MAP kinase cascades in vascular smooth muscle cells. J Pharmacol Toxicol Methods. 2000 Sep-Oct;44(2):429-39. Activation of the mitogen-activated protein kinase (MAP kinase) pathways in cultured porcine aortic vascular smooth muscle cells (VSMCs) was determined following a 5-min stimulation with endothelin-1 (ET-1), phorbol 12- 13- (PMA), H2O2, or sodium arsenite. |
2(0,0,0,2) | Details |
| 17645694 | Lin AM, Fang SF, Chao PL, Yang CH: attenuates arsenite-induced apoptosis in rat brain: involvement of mitochondrial and endoplasmic reticulum pathways and aggregation of alpha-synuclein. J Pineal Res. 2007 Sep;43(2):163-71. In the present study, the protective effect of on sodium arsenite (arsenite)-induced apoptosis was investigated. Furthermore, attenuated arsenite-induced increases in heat shock protein 70 and heme oxygenase-1 as well as phosphorylation of p38 mitogen-activated protein kinase and elevations in cyclooxygenase II and inducible synthase expression. |
1(0,0,0,1) | Details |
| 9873045 | Macfarlane WM, McKinnon CM, Felton-Edkins ZA, Cragg H, James RF, Docherty K: stimulates translocation of the homeodomain transcription factor PDX1 from the cytoplasm to the nucleus in pancreatic beta-cells. J Biol Chem. 1999 Jan 8;274(2):1011-6. One of the mechanisms whereby stimulates insulin gene transcription in pancreatic beta-cells involves activation of the homeodomain transcription factor PDX1 (pancreatic/duodenal homeobox-1) via a stress-activated pathway involving stress-activated protein kinase 2 (SAPK2, also termed RK/p38, CSBP, and Mxi2). These effects of could be mimicked by chemical stress (sodium arsenite), or by overexpression of SAPK2 in the beta-cell line MIN6. |
1(0,0,0,1) | Details |
| 16256366 | Zhao Q, Chen P, Manson ME, Liu Y: Production of active recombinant mitogen-activated protein kinases through transient transfection of 293T cells. Protein Expr Purif. 2006 Apr;46(2):468-74. Epub 2005 Oct 10. We cloned JNK1, p38, and p38-regulated MAP kinase-activated protein kinase-2 into the mammalian expression vector pEBG, and expressed these protein kinases as glutathione S-transferase fusion proteins in human embryonic kidney 293T cells through transient transfection. The protein kinases were activated in vivo through treating the transfected cells with sodium arsenite and affinity-purified using -Sepharose beads. |
1(0,0,0,1) | Details |
| 8665897 | Meier R, Rouse J, Cuenda A, Nebreda AR, Cohen P: Cellular stresses and cytokines activate multiple mitogen-activated-protein kinase kinase homologues in PC12 and KB cells. Eur J Biochem. 1996 Mar 15;236(3):796-805. The identities of the upstream activators of the mitogen-activated protein (MAP) kinase homologues termed stress-activated-protein (SAP) kinase-1 (also known as JNK or SAPK) and SAP kinase-2 (also known as p38, RK and CSBP) were investigated in rat PC12 cells and human KB cells after exposure to cellular stresses and cytokines. In PC12 cells, the same two upstream activators, SAP kinase kinase-1 (SAPKK-1) and SAPKK-2 were activated after exposure to osmotic shock, ultraviolet irradiation or the protein synthesis inhibitor anisomycin, and more weakly in response to sodium arsenite. |
1(0,0,0,1) | Details |
| 18476811 | Zeng Y, Sankala H, Zhang X, Graves PR: Phosphorylation of Argonaute 2 at serine-387 facilitates its localization to processing bodies. Biochem J. 2008 Aug 1;413(3):429-36. Phosphorylation of Ago2 at serine-387 was significantly induced by treatment with sodium arsenite or anisomycin, and arsenite-induced phosphorylation was inhibited by a p38 MAPK (mitogen-activated protein kinase) inhibitor, but not by inhibitors of JNK (c-Jun N-terminal kinase) or MEK [MAPK/ERK (extracellular-signal-regulated kinase) kinase]. Finally, mutation of serine-387 to an residue or treatment of cells with a p38 MAPK inhibitor reduced the localization of Ago2 to processing bodies. |
1(0,0,0,1) | Details |
| 11574405 | Elrick LJ, Docherty K: Phosphorylation-dependent nucleocytoplasmic shuttling of pancreatic duodenal homeobox-1. Diabetes. 2001 Oct;50(10):2244-52. Insulin and sodium arsenite, an activator of the stress-activated pathway, also stimulated PDX-1 movement from the nuclear periphery to the nucleoplasm. and insulin regulate PDX-1 by way of a signaling pathway involving phosphatidylinositol 3-kinase (PI 3-kinase) and SAPK2/p38. |
2(0,0,0,2) | Details |
| 12075113 | Muscarella DE, Bloom SE: Differential activation of the c-Jun N-terminal kinase pathway in arsenite-induced apoptosis and sensitization of chemically resistant compared to susceptible B-lymphoma cell lines. Toxicol Sci. 2002 Jul;68(1):82-92. Therefore, we investigated the involvement of key mitogen-activated protein kinase pathways and apoptosis induction by sodium arsenite in a model system of chemically resistant and susceptible B-lymphoma cell lines. Moreover, pretreatment with an inhibitor of p38 kinase acted synergistically with hyperthermia to further sensitize EW36 cells. |
2(0,0,0,2) | Details |
| 10704466 | Allen M, Svensson L, Roach M, Hambor J, McNeish J, Gabel CA: Deficiency of the stress kinase p38alpha results in embryonic lethality: characterization of the kinase dependence of stress responses of enzyme-deficient embryonic stem cells. J Exp Med. 2000 Mar 6;191(5):859-70. The mitogen-activated protein (MAP) kinase p38 is a key component of stress response pathways and the target of cytokine-suppressing antiinflammatory drugs (CSAIDs). |
2(0,0,0,2) | Details |
| 18754769 | Hansen TE, Puntervoll P, Seternes OM, Jorgensen JB: Atlantic salmon possess three mitogen activated protein kinase kinase 6 paralogs responding differently to stress. FEBS J. 2008 Oct;275(19):4887-902. Epub 2008 Aug 27. Mitogen activated protein kinase kinase (MKK) 3 and 6 are the main p38 mitogen-activated protein kinase activators in mammals. In cells exposed to sodium arsenite and UV radiation, the different salmon MKK6s were shown to be selectively activated. |
2(0,0,0,2) | Details |
| 16797887 | Suzuki T, Tsukamoto I: Arsenite induces apoptosis in hepatocytes through an enhancement of the activation of Jun N-terminal kinase and p38 mitogen-activated protein kinase caused by partial hepatectomy. Toxicol Lett. 2006 Sep 10;165(3):257-64. Epub 2006 May 12. To investigate the effects of arsenite on cell proliferation and the signal transduction in hapatocytes in vivo, rats received a single injection of sodium arsenite immediately after partial hepatectomy. |
2(0,0,0,2) | Details |
| 11525238 | Kato K, Ito H, Iwamoto I, Lida K, Inaguma Y: Protein kinase inhibitors can suppress stress-induced dissociation of Hsp27. Cell Stress Chaperones. 2001 Jan;6(1):16-20. These results suggest that the phosphorylation of Hsp27 is catalyzed by 2 protein kinases, p38 MAP kinase-activated protein (MAPKAP) kinase-2/3 and protein kinase C. |
1(0,0,0,1) | Details |
| 15734884 | Nuntharatanapong N, Chen K, Sinhaseni P, Keaney JF Jr: EGF receptor-dependent JNK activation is involved in arsenite-induced p21Cip1/Waf1 upregulation and endothelial apoptosis. Am J Physiol Heart Circ Physiol. 2005 Jul;289(1):H99-H107. Epub 2005 Feb 25. In this study, we sought to explore the signaling pathway triggered by sodium arsenite and its implication for endothelial phenotype. Arsenite-induced activation of JNK and p38 MAPK was distinct, with only JNK as a downstream target of the EGF receptor. |
1(0,0,0,1) | Details |
| 15327774 | Thomson S, Hollis A, Hazzalin CA, Mahadevan LC: Distinct stimulus-specific histone modifications at hsp70 chromatin targeted by the transcription factor heat shock factor-1. Mol Cell. 2004 Aug 27;15(4):585-94. The stress-inducible gene Hsp70 is activated by heat shock or by sodium arsenite. However, independently of p38 MAP kinase, both stresses strongly activate the transcription factor Hsf1. |
1(0,0,0,1) | Details |
| 19429265 | Das J, Ghosh J, Manna P, Sinha M, Sil PC: protects rat testes against NaAsO (2)-induced oxidative stress and apoptosis via mitochondrial dependent and independent pathways. Toxicol Lett. 2009 Jun 22;187(3):201-10. Epub 2009 Mar 14. Oral administration of (at a dose of 100mg/kg body weight for 5 days) was found to be effective in counteracting As-induced oxidative stress, attenuation of testicular damages and amelioration of apoptosis in testicular tissue by controlling the reciprocal regulation of Bcl-2/Bad, phospho-ERK1/2, phospho-p38, phospho-Akt and NF-kappaB. |
1(0,0,0,1) | Details |
| 9535875 | Elbirt KK, Whitmarsh AJ, Davis RJ, Bonkovsky HL: Mechanism of sodium arsenite-mediated induction of heme oxygenase-1 in hepatoma cells. J Biol Chem. 1998 Apr 10;273(15):8922-31. We conclude that the MAP kinases ERK and p38 are involved in the induction of heme oxygenase-1, and that at least one AP-1 element (located -1576 base pairs upstream of the transcription start site) is involved in this response. |
1(0,0,0,1) | Details |
| 16818494 | Cai B, Chang SH, Becker EB, Bonni A, Xia Z: p38 MAP kinase mediates apoptosis through phosphorylation of BimEL at Ser-65. J Biol Chem. 2006 Sep 1;281(35):25215-22. Epub 2006 Jul 3. Here we report evidence that sodium arsenite-induced apoptosis in PC12 cells may be due to direct phosphorylation of Bim (EL) at Ser-65 by p38. |
165(2,2,2,5) | Details |
| 12482858 | Duyndam MC, Hulscher ST, van der Wall E, Pinedo HM, Boven E: Evidence for a role of p38 kinase in hypoxia-inducible factor 1-independent induction of vascular endothelial growth factor expression by sodium arsenite. J Biol Chem. 2003 Feb 28;278(9):6885-95. Epub 2002 Dec 13. By using kinase inhibitors in OVCAR-3 cells, both effects of sodium arsenite were found to be independent of phosphatidylinositol 3-kinase and p44/p42 MAPKS but were attenuated by inhibition of p38 MAPK. |
113(1,2,2,3) | Details |
| 10779545 | Werz O, Klemm J, Samuelsson B, Radmark O: 5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases. Proc Natl Acad Sci U S A. 2000 May 9;97(10):5261-6. Different agents activated the 5-LO kinase activities, including stimuli for cellular leukotriene biosynthesis (A23187, thapsigargin, N-formyl-leucyl- compounds that up-regulate the capacity for leukotriene biosynthesis (phorbol 12- 13- tumor necrosis factor alpha, granulocyte/macrophage colony-stimulating factor), and well known p38 stimuli as sodium arsenite and |
35(0,1,1,5) | Details |
| 10221768 | Burns CJ, Howell SL, Jones PM, Persaud SJ: The p38 mitogen-activated protein kinase cascade is not required for the stimulation of insulin secretion from rat islets of Langerhans. Mol Cell Endocrinol. 1999 Feb 25;148(1-2):29-35. The cellular stress agents sodium arsenite and hyperosmotic significantly stimulated p38 MAPK activity, as did the phosphatase inhibitor pervanadate and the serine/ phosphatase inhibitor okadaic acid. |
34(0,1,1,4) | Details |
| 8971075 | Sutherland C, Tebbey PW, Granner DK: Oxidative and chemical stress mimic insulin by selectively inhibiting the expression of phosphoenolpyruvate carboxykinase in hepatoma cells. Diabetes. 1997 Jan;46(1):17-22. The reactivating kinase (RK, also known as p38 mitogen activated protein kinase) is induced by insulin, peroxide, or meta-arsenite in hepatoma cells, and these effects are blocked by SB203580, a selective inhibitor of RK. |
1(0,0,0,1) | Details |
| 12749847 | Fernando P, Megeney LA, Heikkila JJ: Phosphorylation-dependent structural alterations in the small hsp30 chaperone are associated with cellular recovery. Exp Cell Res. 2003 Jun 10;286(2):175-85. Both heat stress and sodium arsenite treatment in A6 cells resulted in a rapid activation of p38alpha and MAPKAPK-2. Treatment of A6 cells with SB203580, an inhibitor of the p38 MAP kinase pathway, resulted in a loss of hsp30 phosphorylation. |
1(0,0,0,1) | Details |
| 18465250 | Cai B, Xia Z: p38 MAP kinase mediates arsenite-induced apoptosis through FOXO3a activation and induction of Bim transcription. Apoptosis. 2008 Jun;13(6):803-10. Sodium arsenite induces apoptosis in PC12 cells by activating the stress-activated p38 MAP kinase and the pro-apoptotic Bcl-2 family protein Bim (EL). |
91(1,1,2,6) | Details |
| 8902523 | Liu Y, Guyton KZ, Gorospe M, Xu Q, Lee JC, Holbrook NJ: Differential activation of ERK, JNK/SAPK and P38/CSBP/RK map kinase family members during the cellular response to arsenite. Free Radic Biol Med. 1996;21(6):771-81. In the present study, we examined ERK, JNK/SAPK, and p38 activation in cells treated with the sulfhydryl-reactive agent sodium arsenite. |
85(1,1,1,5) | Details |
| 11035063 | Hossain K, Akhand AA, Kato M, Du J, Takeda K, Wu J, Takeuchi K, Liu W, Suzuki H, Nakashima I: Arsenite induces apoptosis of murine T lymphocytes through membrane raft-linked signaling for activation of c-Jun amino-terminal kinase. J Immunol. 2000 Oct 15;165(8):4290-7. We demonstrated that NaAsO (2)-induced caspase activation is dependent on -sensitive c-Jun amino-terminal kinase and barely dependent on SB203580-sensitive p38 kinase or PD98059-sensitive extracellular signal-regulated kinase. |
1(0,0,0,1) | Details |
| 9712902 | Cheong J, Coligan JE, Shuman JD: Activating transcription factor-2 regulates phosphoenolpyruvate carboxykinase transcription through a stress-inducible mitogen-activated protein kinase pathway. J Biol Chem. 1998 Aug 28;273(35):22714-8. In this regard, we show that treatment with sodium arsenite, a known activator of p38 MAP kinases, also stimulates expression from the PEPCK promoter. |
82(1,1,1,2) | Details |
| 14962831 | Liu Q, Hofmann PA: Protein phosphatase 2A-mediated cross-talk between p38 MAPK and ERK in apoptosis of cardiac myocytes. Am J Physiol Heart Circ Physiol. 2004 Jun;286(6):H2204-12. Epub 2004 Feb 12. We demonstrated that inhibition of p38 MAPK with SB-203580 and SB-239063 enhanced H (2) O (2)-stimulated ERK phosphorylation, whereas preactivation of p38 MAPK with sodium arsenite reduced H (2) O (2)-stimulated ERK phosphorylation. |
36(0,1,1,6) | Details |
| 18715270 | Lin AM, Feng SF, Chao PL, Yang CH: inhibits arsenite-induced peripheral neurotoxicity. J Pineal Res. 2009 Jan;46(1):64-70. Epub 2008 Aug 18. In this study, the effect of on sodium arsenite (arsenite)-induced peripheral neurotoxicity was investigated using dorsal root ganglion (DRG) explants. Furthermore, inhibited arsenite-induced phosphorylation of p38 and DNA fragmentation. |
1(0,0,0,1) | Details |
| 18836437 | Arimoto K, Fukuda H, Imajoh-Ohmi S, Saito H, Takekawa M: Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathways. Nat Cell Biol. 2008 Nov;10(11):1324-32. Epub 2008 Oct 5. Type 2 stress, which includes X-rays and genotoxic drugs, induce apoptosis through the stress-activated p38 and JNK MAPK (SAPK) pathways. |
1(0,0,0,1) | Details |
| 11160250 | Chakravortty D, Kato Y, Sugiyama T, Koide N, Mu MM, Yoshida T, Yokochi T: The inhibitory action of sodium arsenite on lipopolysaccharide-induced production in RAW 267.4 macrophage cells: a role of Raf-1 in lipopolysaccharide signaling. J Immunol. 2001 Feb 1;166(3):2011-7. |
0(0,0,0,0) | Details |
| 10986282 | Yu R, Chen C, Mo YY, Hebbar V, Owuor ED, Tan TH, Kong AN: Activation of mitogen-activated protein kinase pathways induces antioxidant response element-mediated gene expression via a Nrf2-dependent mechanism. J Biol Chem. 2000 Dec 22;275(51):39907-13. Here, we report that the expression of mitogen-activated protein (MAP) kinase/extracellular signal-regulated kinase kinase kinase 1 (MEKK1), transforming growth factor-beta-activated kinase (TAK1), and apoptosis signal-regulating kinase (ASK1) in HepG2 cells activated the ARE reporter gene, whereas the expression of their dominant-negative mutants impaired ARE activation by the chemicals sodium arsenite and mercury |
0(0,0,0,0) | Details |
| 9299480 | Wang X, Proud CG: p70 S6 kinase is activated by sodium arsenite in adult rat cardiomyocytes: roles for phosphatidylinositol 3-kinase and p38 MAP kinase. Biochem Biophys Res Commun. 1997 Sep 8;238(1):207-12. |
32(0,1,1,2) | Details |
| 11807808 | Kim JY, Choi JA, Kim TH, Yoo YD, Kim JI, Lee YJ, Yoo SY, Cho CK, Lee YS, Lee SJ: Involvement of p38 mitogen-activated protein kinase in the cell growth inhibition by sodium arsenite. J Cell Physiol. 2002 Jan;190(1):29-37. |
32(0,1,1,2) | Details |
| 9288946 | Thomas G, Haavik J, Cohen P: Participation of a stress-activated protein kinase cascade in the activation of tyrosine hydroxylase in chromaffin cells. Eur J Biochem. 1997 Aug 1;247(3):1180-9. Sodium arsenite and osmotic shock both stimulated stress-activated protein kinase-2 (SAPK2, also termed RK, p38, CSBP and Mxi2) and its downstream target mitogen-activated protein kinase (MAP kinase)-activated protein kinase-2 (MAPKAP-K2) in bovine chromaffin and rat PC12 cells. |
31(0,1,1,1) | Details |
| 10964950 | Namgung U, Xia Z: Arsenite-induced apoptosis in cortical neurons is mediated by c-Jun N-terminal protein kinase 3 and p38 mitogen-activated protein kinase. J Neurosci. 2000 Sep 1;20(17):6442-51. Here we investigated the role of JNK and p38 in cortical neuron apoptosis caused by sodium arsenite treatment. |
12(0,0,1,7) | Details |
| 17961518 | DeFuria J, Shea TB: Arsenic inhibits neurofilament transport and induces perikaryal accumulation of phosphorylated neurofilaments: roles of JNK and GSK-3beta. Brain Res. 2007 Nov 21;1181:74-82. Epub 2007 Apr 12. We examined herein the impact of sodium arsenite (the inorganic form of arsenic) on NF dynamics. |
0(0,0,0,0) | Details |
| 9877156 | McDowell HE, Eyers PA, Hundal HS: Regulation of System A amino acid transport in L6 rat skeletal muscle cells by insulin, chemical and hyperthermic stress. FEBS Lett. 1998 Dec 11;441(1):15-9. Uptake of alpha-methyl-aminoisobutyric acid (Me-AIB), a non-metabolisable System A substrate, was increased by between 50% and 80% when muscle cells were exposed to a maximally effective concentration of insulin (100 nM), sodium arsenite (ARS, 0.5 mM) or a 42 degrees C heat shock (HS). |
0(0,0,0,0) | Details |
| 9722676 | Masuya Y, Hioki K, Tokunaga R, Taketani S: Involvement of the phosphorylation pathway in induction of human heme oxygenase-1 by hemin, sodium arsenite, and cadmium J Biochem. 1998 Sep;124(3):628-33. |
0(0,0,0,0) | Details |
| 9688607 | Hedges JC, Yamboliev IA, Ngo M, Horowitz B, Adam LP, Gerthoffer WT: p38 mitogen-activated protein kinase expression and activation in smooth muscle. Am J Physiol. 1998 Aug;275(2 Pt 1):C527-34. |
10(0,0,0,10) | Details |
| 17373649 | Li JP, Yang JL: Cyclin B1 proteolysis via p38 MAPK signaling participates in G2 checkpoint elicited by arsenite. J Cell Physiol. 2007 Aug;212(2):481-8. |
6(0,0,0,6) | Details |
| 9768359 | Ben-Levy R, Hooper S, Wilson R, Paterson HF, Marshall CJ: Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2. Curr Biol. 1998 Sep 24;8(19):1049-57. |
6(0,0,0,6) | Details |
| 12842450 | Carter Y, Liu G, Stephens WB, Carter G, Yang J, Mendez C: Heat shock protein (HSP72) and p38 MAPK involvement in sublethal hemorrhage (SLH)-induced tolerance. J Surg Res. 2003 May 1;111(1):70-7. This study investigated if SLH induces in vivo HSP72 expression and whether in vitro HSP72 induction by sodium arsenite (NaArs) alters intracellular signal transduction and cytokine production similar to SLH. |
5(0,0,0,5) | Details |
| 19616567 | Ghosh J, Das J, Manna P, Sil PC: prevents arsenic-induced cardiac oxidative stress and apoptotic damage: role of NF-kappa B, p38 and JNK MAPK pathway. Toxicol Appl Pharmacol. 2009 Oct 1;240(1):73-87. Epub 2009 Jul 17. |
4(0,0,0,4) | Details |