| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | sodium arsenite |
|---|---|
| CAS | sodium arsenenite |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8431965 | Falkner KC, McCallum GP, Cherian MG, Bend JR: Effects of acute sodium arsenite administration on the pulmonary chemical metabolizing enzymes, cytochrome P-450 monooxygenase, NAD (P) H:quinone acceptor oxidoreductase and glutathione S-transferase in guinea pig: comparison with effects in liver and kidney. Chem Biol Interact. 1993 Jan;86(1):51-68. |
87(1,1,2,2) | Details |
| 7600446 | Albores A, Sinal CJ, Cherian MG, Bend JR: Selective increase of rat lung cytochrome P450 1A1 dependent monooxygenase activity after acute sodium arsenite administration. Can J Physiol Pharmacol. 1995 Jan;73(1):153-8. Consequently, the ability of arsenite (As3+) to modulate isozyme-selective cytochrome P450 (P450) dependent monooxygenase activities was investigated in microsomes prepared from lung, liver, and kidney of male, adult Sprague-Dawley rats treated subcutaneously (s.c.) with sodium arsenite (75 mumol/kg body weight) 24 h before death. |
31(0,1,1,1) | Details |
| 6895259 | Sardana MK, Drummond GS, Sassa S, Kappas A: The potent heme oxygenase inducing action of arsenic and parasiticidal arsenicals. Pharmacology. 1981;23(5):247-53. The administration of trivalent arsenic, either as sodium arsenite or as the trypanocidal drug melarsoprol, to rats produced a profound induction of microsomal heme oxygenase (EC 1.14.99.3) in both liver and kidney and a concomitant decrease in cytochrome P-450 content. |
6(0,0,1,1) | Details |
| 10525283 | Jacobs JM, Marek D, Walton HS, Sinclair PR, Sinclair JF: Effect of sodium arsenite on heme metabolism in cultured chick embryo hepatocytes. Arch Biochem Biophys. 1999 Nov 1;371(1):8-14. We had previously reported that low concentrations of sodium arsenite (1-5 microM) decreased the induction of cytochrome P450 CYP1A and CYP2H in cultured chick embryo hepatocytes in parallel with increases in heme oxygenase. |
6(0,0,1,1) | Details |
| 8992607 | Albores A, Cebrian ME, Garcia-Vargas GG, Connelly JC, Price SC, Hinton RH, Bach PH, Bridges JW: Enhanced arsenite-induced hepatic morphological and biochemical changes in phenobarbital-pretreated rats. Toxicol Pathol. 1996 Mar-Apr;24(2):172-80. Changes in liver morphology and biochemistry have been assessed 16 hr after a sc injection of sodium arsenite [As (III), 75 mumol/kg] to control and phenobarbital (PB)-pretreated (80 mg/kg, ip daily for 3 days) adult male Wistar rats. There was a 30% decrease in total hepatic cytochrome P-450 (CYP450). |
2(0,0,0,2) | Details |
| 2593134 | Albores A, Cebrian ME, Bach PH, Connelly JC, Hinton RH, Bridges JW: Sodium arsenite induced alterations in excretion and heme metabolism. J Biochem Toxicol. 1989 Summer;4(2):73-8. The first stage was an increase in the cytosolic "free" heme without significant effects on the content of cytochrome P-450 or on excretion. |
2(0,0,0,2) | Details |
| 11368792 | Ding S, Yao D, Deeni YY, Burchell B, Wolf CR, Friedberg T: Human -P450 oxidoreductase modulates the level of cytochrome P450 CYP2D6 holoprotein via haem oxygenase-dependent and -independent pathways. Biochem J. 2001 Jun 1;356(Pt 2):613-9. Furthermore, treatment of cells with sodium arsenite increased levels of haem oxygenase concomitant with a marked decrease of spectrally detectable CYP2D6 and a rise in levels of ferritin, which sequesters free iron released from the destruction of haem. |
2(0,0,0,2) | Details |
| 16125204 | Shinno E, Shimoji M, Imaizumi N, Kinoshita S, Sunakawa H, Aniya Y: Activation of rat liver microsomal glutathione S-transferase by Life Sci. 2005 Nov 19;78(1):99-106. Epub 2005 Aug 25. The MGST1 activity increased by was decreased by further incubation with sodium arsenite, a sulfenic acid reducing agent, but was not with a disulfide bond reducing agent. The incubation of microsomes with in the presence of the generating system which generates reactive species (ROS) through cytochrome P-450 system increased the MGST1activity in spite of scavenging the ROS and the increase was also depressed by SOD/catalase. |
1(0,0,0,1) | Details |
| 18528686 | Naraharisetti SB, Aggarwal M, Sarkar SN, Malik JK: Concurrent subacute exposure to arsenic through drinking water and malathion via diet in male rats: effects on hepatic drug-metabolizing enzymes. Arch Toxicol. 2008 Aug;82(8):543-51. Epub 2008 Jun 5. At term, toxicity was assessed by evaluating changes in body weight, liver weight, levels of cytochrome P (450) (CYP), cytochrome b (5) and microsomal and cytosolic proteins, and activities of aminopyrine-N-demethylase (ANDM), -P-hydroxylase (APH), glutathione-S-transferase (GST) and glucuronosyltransferase (UGT) in liver. |
1(0,0,0,1) | Details |
| 16433889 | Bashir S, Sharma Y, Irshad M, Gupta SD, Dogra TD: Arsenic-induced cell death in liver and brain of experimental rats. Basic Clin Pharmacol Toxicol. 2006 Jan;98(1):38-43. Sodium arsenite was administered orally at doses of 6.3 mg/kg, 10.5 mg/kg and 12.6 mg/kg of body weight on the basis of a lethal dose 50% (LD50) for 24 hr. In liver the following biochemical changes were observed, a significant lipid peroxidation and cytochrome-P450 induction along with significant decrease in catalase and superoxide dismutase was observed at 10.5 mg/kg and 12.6 mg/kg. |
1(0,0,0,1) | Details |
| 19084030 | Medina-Diaz IM, Estrada-Muniz E, Reyes-Hernandez OD, Ramirez P, Vega L, Elizondo G: Arsenite and its metabolites, MMA (III) and DMA (III), modify CYP3A4, PXR and RXR alpha expression in the small intestine of CYP3A4 transgenic mice. Toxicol Appl Pharmacol. 2009 Sep 1;239(2):162-8. Epub 2008 Nov 24. Cytochrome P450 (P450) modification may be one of the factors contributing to these disorders. The present study investigates the effect of sodium arsenite and its metabolites monomethylarsonous acid (MMA (III)) and dimethylarsinous acid (DMA (III)) on CYP3A4, PXR, and RXR alpha expression in the small intestine of CYP3A4 transgenic mice. |
1(0,0,0,1) | Details |
| 18288313 | Davey JC, Nomikos AP, Wungjiranirun M, Sherman JR, Ingram L, Batki C, Lariviere JP, Hamilton JW: Arsenic as an endocrine disruptor: arsenic disrupts receptor-and thyroid hormone receptor-mediated gene regulation and thyroid hormone-mediated amphibian tail metamorphosis. Environ Health Perspect. 2008 Feb;116(2):165-72. METHODS AND RESULTS: Human embryonic NT2 or rat pituitary GH3 cells were treated with 0.01-5 microM sodium arsenite for 24 hr, with or without RA or TH, respectively, to examine effects of As on receptor-mediated gene transcription. At low, noncytotoxic doses, As significantly altered RAR-dependent gene transcription of a transfected RAR response element-luciferase construct and the native RA-inducible cytochrome P450 CYP26A gene in NT2 cells. |
1(0,0,0,1) | Details |
| 12723893 | Ramanathan K, Shila S, Kumaran S, Panneerselvam C: Protective role of and on arsenic-induced microsomal dysfunctions. Hum Exp Toxicol. 2003 Mar;22(3):129-36. and treatment decreases the activity of haem oxygenase, whereas it increases the levels/ activity of cytochrome P450, cytochrome b5 and NADPH-cytochrome P450 reductase in arsenic-intoxicated rats. |
1(0,0,0,1) | Details |
| 11854143 | Spink DC, Katz BH, Hussain MM, Spink BC, Wu SJ, Liu N, Pause R, Kaminsky LS: Induction of CYP1A1 and CYP1B1 in T-47D human breast cancer cells by benzo [a] pyrene is diminished by arsenite. Drug Metab Dispos. 2002 Mar;30(3):262-9. Polycyclic aromatic hydrocarbons (PAHs) and metals are often environmental cocontaminants, yet there have been relatively few studies of combined effects of PAHs and metals on cytochrome P450 (P450)-catalyzed metabolism. |
1(0,0,0,1) | Details |
| 11353140 | Liu J, Kadiiska MB, Liu Y, Lu T, Qu W, Waalkes MP: Stress-related gene expression in mice treated with inorganic arsenicals. Toxicol Sci. 2001 Jun;61(2):314-20. Mice were injected sc with either sodium arsenite [As (III), 100 micromol/kg], arsenate [As (V), 300 micromol/kg], or saline. Downregulation of certain cytochrome P450 enzymes occurred with arsenic treatment. |
1(0,0,0,1) | Details |
| 15964037 | Requejo R, Tena M: Proteome analysis of maize roots reveals that oxidative stress is a main contributing factor to plant arsenic toxicity. Phytochemistry. 2005 Jul;66(13):1519-28. Maize seedlings were fed hydroponically with 300 microM arsenate or 250 microM sodium arsenite for 24 h, and changes in differentially displayed proteins were studied by two-dimensional electrophoresis and digital image analysis. The set of identified maize root proteins highly responsive to arsenic exposure included a major and functionally homogeneous group of seven enzymes involved in cellular homeostasis for redox perturbation (e.g., three superoxide dismutases, two peroxidases, one peroxiredoxin, and one reductase) besides four additional, functionally heterogeneous, proteins (e.g., ATP synthase, synthetase, cytochrome P450 and guanine nucleotide-binding protein beta subunit). |
1(0,0,0,1) | Details |
| 16288947 | Bashir S, Sharma Y, Irshad M, Nag TC, Tiwari M, Kabra M, Dogra TD: Arsenic induced apoptosis in rat liver following repeated 60 days exposure. Toxicology. 2006 Jan 5;217(1):63-70. Epub 2005 Nov 9. RESULTS: A significant increase in cytochrome-P450 and lipid peroxidation accompanied with a significant alteration in the activity of many of the antioxidants was observed, all suggestive of arsenic induced oxidative stress. AIM: The present study was focused to elucidate the role of free radicals in arsenic toxicity and to investigate the nature of in vivo sodium arsenite induced cell death in liver. |
1(0,0,0,1) | Details |
| 9261921 | Brown JL, Kitchin KT, George M: Dimethylarsinic acid treatment alters six different rat biochemical parameters: relevance to arsenic carcinogenesis. Teratog Carcinog Mutagen. 1997;17(2):71-84. In a previous study, we found that sodium arsenite increased hepatic ornithine decarboxylase (ODC) activity and hepatic heme oxygenase (HO) activity, but did not cause any DNA damage in adult female rat liver or lung, suggesting that arsenite may be a promoter of carcinogenesis. DNA damage (DD), cytochrome P450 content (P450), content (GSH), ODC, serum alanine aminotransferase (ALT) and HO were measured in liver and/or lung tissue. |
1(0,0,0,1) | Details |
| 9604300 | Price RJ, Ball SE, Renwick AB, Barton PT, Beamand JA, Lake BG: Use of precision-cut rat liver slices for studies of xenobiotic metabolism and toxicity: comparison of the Krumdieck and Brendel tissue slicers. Xenobiotica. 1998 Apr;28(4):361-71. GSH and (GSH) and cytochrome P450 and activities of 7-ethoxyresorufin O-deethylase and 7-benzoxyresorufin O-debenzylase in freshly cut rat liver slices produced by the two tissue slicers. With liver slices produced by both tissue slicers 50 microM sodium arsenite produced a greater induction of heat shock protein 70 levels in slices cultured for 24 h in a high than in an air atmosphere. 6. |
1(0,0,0,1) | Details |
| 8556713 | Brown JL, Kitchin KT: Arsenite, but not cadmium, induces ornithine decarboxylase and heme oxygenase activity in rat liver: relevance to arsenic carcinogenesis. Cancer Lett. 1996 Jan 2;98(2):227-31. Sodium arsenite and cadmium were administered orally to adult female rats at 21 and 4 h prior to sacrifice. DNA damage, cytochrome P450, content (GSH), ornithine decarboxylase (ODC), serum alanine aminotransferase and heme oxygenase activity were measured. |
1(0,0,0,1) | Details |
| 3236342 | Cebrian ME, Albores A, Connelly JC, Bridges JW: Assessment of arsenic effects on cytosolic heme status using tryptophan pyrrolase as an index. J Biochem Toxicol. 1988 Summer;3:77-86. Acute arsenic (As) administration produced in rat liver a decrease in the heme saturation of tryptophan pyrrolase (TP), accompanied by dose-related increases in synthetase (ALAS) and heme oxygenase (HO) activities, along with a corresponding decrease in cytochrome P-450 (P-450) concentration. The magnitude of these effects was related to the oxidation state of arsenic, sodium arsenite (AsIII) being more potent than arsenate (AsV). |
1(0,0,0,1) | Details |