| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | acetochlor |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 1818121 | Antov G, Zaikov C, Bouzidi A, Mitova S, Michaelova A, Halkova J, Choumkov N: [Biochemical and histological changes after acute oral poisoning with the acetanilide herbicide acetochlor]. J Toxicol Clin Exp. 1991 Oct;11(6):349-56. Remarkable is the compensatory effect of the cytochrome P-450 system responsible for the metabolism of acetochlor. |
81(1,1,1,1) | Details |
| 11133395 | Coleman S, Linderman R, Hodgson E, Rose RL: Comparative metabolism of chloroacetamide herbicides and selected metabolites in human and rat liver microsomes. Environ Health Perspect. 2000 Dec;108(12):1151-7. We have also shown that the cytochrome P450 isoforms responsible for human metabolism of acetochlor, butachlor, and metolachlor are CYP3A4 and CYP2B6. |
81(1,1,1,1) | Details |
| 11029275 | Green T, Lee R, Moore RB, Ashby J, Willis GA, Lund VJ, Clapp MJ: Acetochlor-induced rat nasal tumors: further studies on the mode of action and relevance to humans. Regul Toxicol Pharmacol. 2000 Aug;32(1):127-33. The formation of a -imine from the sulfoxide was facilitated by hydroxylation of the phenyl ring by a cytochrome P450 isoenzyme which was specific to the nasal epithelium in the rat. |
1(0,0,0,1) | Details |
| 10910473 | Rakitsky VN, Koblyakov VA, Turusov VS: Nongenotoxic (epigenetic) carcinogens: pesticides as an example. Teratog Carcinog Mutagen. 2000;20(4):229-40. There exist examples of lack of correlation between genotoxicity and carcinogenicity: some pesticides are genotoxic (although not strongly) but noncarcinogenic, others are considered as nongenotoxic but are strongly carcinogenic (chlorothalonil, acetochlor). The general scheme of the promoters' effect is presented in which an important role is attributed to the cytochrome P-450 induction (some pesticides are the cytochrome P-450 inducers), formation of reactive species and peroxitome proliferation. |
1(0,0,0,1) | Details |
| 18217708 | Hirose S, Kawahigashi H, Tagiri A, Ohkawa Y: Herbicide-induced anthocyanin accumulation in transgenic rice by expression of rice OSB2 under the control of rice CYP72A21 promoter. J Agric Food Chem. 2008 Feb 27;56(4):1259-63. Epub 2008 Jan 25. CYP72A21, a rice cytochrome P450 gene, is induced by chloroacetamide herbicides. Leaves of the transgenic plants turned red upon treatment with the chloroacetamide herbicides acetochlor, alachlor, and metolachlor. |
1(0,0,0,1) | Details |