Protein Information

Name cytochrome c
Synonyms CYC; CYCS; Cytochrome C; HCS; Cytochrome Cs

Compound Information

Name 2,4-D
CAS 2-(2,4-dichlorophenoxy)acetic acid

Reference List

PubMed Abstract RScore(About this table)
8157865 Pereira LF, Campello AP, Silveira O: Effect of Tordon 2,4-D 64/240 triethanolamine BR on the energy metabolism of rat liver mitochondria. J Appl Toxicol. 1994 Jan-Feb;14(1):21-6.

Tordon herbicide, which is a mixture of 4-amino-3,5,6-trichloropicolinic acid (picloram) and 2,4-dichlorophenoxyacetic acid (2,4-D), depresses the phosphorylation efficiency of the rat liver mitochondria, as inferred from the decrease of the respiratory control coefficient and the ADP/O ratios when NAD (+)-dependent substrates were used; NADH oxidase and NADH cytochrome c reductase were also inhibited, without any effect on the other enzymatic complexes of the respiratory chain.
31(0,1,1,1) Details
12512947 De Moliner KL, Evangelista de Duffard AM, Soto E, Duffard R, Adamo AM: Induction of apoptosis in cerebellar granule cells by 2,4-dichlorophenoxyacetic acid. Neurochem Res. 2002 Nov;27(11):1439-46.

Treatment of CGC with 2,4-D appears to induce apoptosis by a direct effect on mitochondria producing cytochrome c release and consequently activation of caspase-3, being mitochondrial damage sufficient for triggering the events that may cause apoptosis.
32(0,1,1,2) Details
12520332 Carimi F, Zottini M, Formentin E, Terzi M, Lo Schiavo F: Cytokinins: new apoptotic inducers in plants. Planta. 2003 Jan;216(3):413-21. Epub 2002 Sep 17.

In the present work, cell death was scored by Evan's blue staining and was also demonstrated to be programmed by various parameters, including chromatin condensation, oligonucleosomal DNA degradation (laddering), and release of cytochrome c from mitochondria.
Two hormones, namely abscisic acid and 2,4-dichlorophenoxyacetic acid (2,4-D), protect cells against the cytokinin-induced death.
1(0,0,0,1) Details
8048053 Palmeira CM, Moreno AJ, Madeira VM: Interactions of herbicides 2,4-D and dinoseb with liver mitochondrial bioenergetics. Toxicol Appl Pharmacol. 1994 Jul;127(1):50-7.

0(0,0,0,0) Details