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2,4-D

Identification (Source:EPA,EU)

ID	1010
Name	2,4-D
CAS	94-75-7
IUPAC	(2,4-dichlorophenoxy)acetic acid
Inchi	InChI=1S/C8H6Cl2O3/c9-5-1-2-7(6(10)3-5)13-4-8(11)12/h1-3H,4H2,(H,11,12)
CIPAC	1
EPA Code	030001
Formula	C8H6Cl2O3
SMILES	Clc1cc(Cl)ccc1OCC(=O)O
Status	Approved

Classification

Mode of Action	Selective, systemic, absorbed through roots and increases biosynthesis and production of ethylene causing uncontrolled cell division and so damages vascular tissue. Synthetic auxin.
Pesticide Type	Herbicide, Plant Growth Regulator, Metabolite
Chemical Group	Alkylchlorophenoxy
Classification	phenoxyacetic herbicides auxins

Properties (Source:PubChem)

Molecular Weight	221.04
Physical State	White powder
AlogP	2.623
H-Bond Donor	1
H-Bond Acceptor	3
Surface Area	197.33
Polar Surface Area	46.53

Structure

Ecotoxicology (Source:PPDB,IPM)

Species	Method	Study Time	Dose Type	Value
Algae	Chronic	96 hour	NOEC, growth	100 mg l-1
Algae	Acute	72 hour	EC50, growth	24.2 mg l-1
Aquatic invertebrates	Acute	48 hour	EC50	100 mg l-1
Aquatic invertebrates	Chronic	21 day	NOEC	32 mg l-1
Aquatic plants	Acute	7 day	EC50, biomass	0.58 mg l-1
Birds	Short term dietary		LC50/LD50	> 5620 mg/kg
Birds	Acute		LD50	> 500 mg kg-1
Earthworms	Acute	14 day	LD50	350 mg kg-1
Fish	Chronic	21 day	NOEC	27.2 mg l-1
Fish	Acute	96 hour	LC50	100 mg l-1
Honeybees	Acute	48 hour	LD50	94 μg bee-1
Mammals	Acute oral		LD50	469 mg kg-1
Mammals	Short term dietary		NOEL	25 mg kg-1
	Bio-concentration factor		CT50	Not available days
	Bio-concentration factor		BCF	10

Related targets

Target Name	RScore (About this table)
glutathione S transferases	375(3,6,11,20)	Details
albumin	285(3,4,5,10)	Details
organic anion transporter 3	180(2,2,4,10)	Details
caspase 3	163(2,2,2,3)	Details
caspase 9	162(2,2,2,2)	Details
ATPase	355(1,6,21,50)	Details
casein	225(1,4,12,15)	Details
alkaline phosphatase	169(1,3,6,14)	Details
SPI1	151(1,3,4,6)	Details
IgE	146(1,3,3,6)	Details
SMAP2	145(1,3,3,5)	Details
MAPK (protein family or complex)	115(1,2,2,5)	Details
calcium channel (protein family or complex)	113(1,2,2,3)	Details
muscles	154(1,1,10,29)	Details
Acetylcholinesterase	124(1,1,7,14)	Details
Myosin	98(1,1,3,8)	Details
c Myc	91(1,1,2,6)	Details
calmodulin	86(1,1,1,6)	Details
GSH S	83(1,1,1,3)	Details
chemokine	83(1,1,1,3)	Details
B15	83(1,1,1,3)	Details
caspases (protein family or complex)	82(1,1,1,2)	Details
CYP1	82(1,1,1,2)	Details
protein disulfide isomerase	82(1,1,1,2)	Details
NIPA	82(1,1,1,2)	Details
sulfate transporter	81(1,1,1,1)	Details
cyclin B1	81(1,1,1,1)	Details
alpha L fucosidase	81(1,1,1,1)	Details
organic anion transporter	81(1,1,1,1)	Details
SMAP1	96(0,3,3,6)	Details
P230	69(0,2,3,4)	Details
TPO1	65(0,2,2,5)	Details
cytochrome c	64(0,2,2,4)	Details
ubiquitin	64(0,2,2,4)	Details
catalase	83(0,1,6,28)	Details
beta glucuronidase	69(0,1,5,19)	Details
LDH3	49(0,1,4,4)	Details
DP 2	43(0,1,3,3)	Details
Hsp70	39(0,1,2,4)	Details
S rRNA	39(0,1,2,4)	Details
ornithine decarboxylase	38(0,1,2,3)	Details
Arginine Decarboxylase	38(0,1,2,3)	Details
tyrosine hydroxylase	38(0,1,2,3)	Details
beta glucosidase	35(0,1,1,5)	Details
AMPH	35(0,1,1,5)	Details
arginase	34(0,1,1,4)	Details
arylsulfatase	33(0,1,1,3)	Details
P270	33(0,1,1,3)	Details
NPR1	33(0,1,1,3)	Details
transferase	33(0,1,1,3)	Details
SMALL ACIDIC PROTEIN	33(0,1,1,3)	Details
cullin	32(0,1,1,2)	Details
stearoyl CoA desaturase	32(0,1,1,2)	Details
per 1	32(0,1,1,2)	Details
dopamine beta hydroxylase	32(0,1,1,2)	Details
MOLT	31(0,1,1,1)	Details
NADPH cytochrome P450 reductase	31(0,1,1,1)	Details
eotaxin	31(0,1,1,1)	Details
Basalin	31(0,1,1,1)	Details
IL 10	31(0,1,1,1)	Details
IL 4	31(0,1,1,1)	Details
tph 2	31(0,1,1,1)	Details
myelin basic protein	31(0,1,1,1)	Details
brain 2	31(0,1,1,1)	Details
protein kinase A (protein family or complex)	31(0,1,1,1)	Details
cis 4	31(0,1,1,1)	Details
IL 13	31(0,1,1,1)	Details
ASK1	31(0,1,1,1)	Details
IL 5	31(0,1,1,1)	Details
quaking proteins	31(0,1,1,1)	Details
Fas receptor	31(0,1,1,1)	Details
superoxide dismutase	41(0,0,6,11)	Details
lactate dehydrogenase (protein family or complex)	30(0,0,4,10)	Details
SERK1	23(0,0,3,8)	Details
glutathione reductase	21(0,0,3,6)	Details
C18	19(0,0,2,9)	Details
hemoglobin (protein family or complex)	17(0,0,2,7)	Details
chitinase	17(0,0,1,12)	Details
aspartate aminotransferase	16(0,0,2,6)	Details
alanine aminotransferase	16(0,0,2,6)	Details

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