Protein Information

Name stearoyl CoA desaturase
Synonyms Acyl CoA desaturase; Acyl Coenzyme A desaturase; Delta(9) desaturase; Delta 9 desaturase; FADS 5; FADS5; Fatty acid desaturase; PRO0998…

Compound Information

Name 2,4-D
CAS 2-(2,4-dichlorophenoxy)acetic acid

Reference List

PubMed Abstract RScore(About this table)
15781260 Viegas CA, Cabral MG, Teixeira MC, Neumann G, Heipieper HJ, Sa-Correia I: Yeast adaptation to 2,4-dichlorophenoxyacetic acid involves increased membrane fatty acid saturation degree and decreased OLE1 transcription. Biochem Biophys Res Commun. 2005 Apr 29;330(1):271-8.

The decreased transcription of the OLE1 gene (encoding the Delta9 fatty acid desaturase that catalyses the conversion of palmitic and stearic acids to palmitoleic and oleic acids, respectively) registered in 2,4-D adapted cells suggests that yeast adaptation to the herbicide involves the enhancement of the ratio of saturated (C (16:0) and C (18:0)) to monounsaturated (C (16:1) and C (18:1)) membrane fatty acids through a reduced OLE1 expression.
31(0,1,1,1) Details
6470926 Kawashima Y, Hanioka N, Kozuka H: Induction of microsomal stearoyl-CoA desaturase by the administration of various phenoxyacetic acid derivatives. J Pharmacobiodyn. 1984 May;7(5):286-93.

The other four phenoxyacetic acid derivatives, 2-(phenoxy)-propionic acid, 4-chlorophenoxyacetic acid, 2-chlorophenoxyacetic acid and 2, 4-dichlorophenoxyacetic acid (2,4-D) changed scarcely the desaturation activity.
1(0,0,0,1) Details