| Name | glutathione S transferases |
|---|---|
| Synonyms | GST class alpha 2; Gst2; GST class alpha; GST class alpha member 2; GST gamma; GSTA 2; GSTA2; GSTA2 2… |
| Name | 2,4-D |
|---|---|
| CAS | 2-(2,4-dichlorophenoxy)acetic acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7480325 | Bilang J, Sturm A: Cloning and characterization of a glutathione S-transferase that can be photolabeled with 5-azido- Plant Physiol. 1995 Sep;109(1):253-60. Auxins reduced enzyme activity only at high concentrations, with 2,4-dichlorophenoxyacetic acid (2,4-D) and 2,4,5-trichlorophenoxyacetic acid being more effective than (IAA) and naphthylacetic acid. |
2(0,0,0,2) | Details |
| 14984703 | Oruc EO, Sevgiler Y, Uner N: Tissue-specific oxidative stress responses in fish exposed to 2,4-D and azinphosmethyl. Comp Biochem Physiol C Toxicol Pharmacol. 2004 Jan;137(1):43-51. Glutathione S-transferase (GST) activity was higher than the control levels in kidney of both fish exposed to pesticides. |
1(0,0,0,1) | Details |
| 3969683 | Hietanen E, Ahotupa M, Heinonen T, Hamalainen H, Kunnas T, Linnainmaa K, Mantyla E, Vainio H: Enhanced peroxisomal beta-oxidation of fatty acids and glutathione metabolism in rats exposed to phenoxyacetic acids. Toxicology. 1985 Feb;34(2):103-11. Peroxisomal beta-oxidation of fatty acids and the activities of -metabolizing enzymes in rat liver were measured after administration of 2,4-dichlorophenoxyacetic acid (2,4-D), 4-chloro-2-methylphenoxyacetic acid (MCPA), clofibrate [ethyl], 2-(p-chlorophenoxy)- (N-phosphonomethyl a herbicide not structurally related to phenoxy acids) or saline for 14 days. beta-Oxidation increased by 6-fold in the group given clofibrate, 3-fold in the 2,4-D-treated group, and 2-fold in the MCPA-treated group over the level in the controls (saline-treated). A slight decrease in glutathione S-transferase activity was found in the group treated with clofibrate. |
1(0,0,0,1) | Details |
| 12242687 | Oruc EO, Uner N: Marker enzyme assessment in the liver of cyprinus carpio (L.) exposed to 2,4-D and azinphosmethyl. J Biochem Mol Toxicol. 2002;16(4):182-8. The most sensitive parameter was glutathione S-transferase (GST) activity, which significantly increased with experimental exposures. |
1(0,0,0,1) | Details |
| 11246500 | Oruc EO, Uner N: Combined effects of 2,4-D and azinphosmethyl on antioxidant enzymes and lipid peroxidation in liver of Oreochromis niloticus. Comp Biochem Physiol C Toxicol Pharmacol. 2000 Dec;127(3):291-6. |
0(0,0,0,0) | Details |
| 6719464 | Vessey DA, Boyer TD: Differential activation and inhibition of different forms of rat liver glutathione S-transferase by the herbicides 2,4-dichlorophenoxyacetate (2,4-D) and 2,4,5-trichlorophenoxyacetate (2,4,5-T). Toxicol Appl Pharmacol. 1984 May;73(3):492-9. Glutathione S-transferase form YaYa was maximally inhibited by 72 and 30%, respectively, by 2,4-D and 2,4,5-T. |
194(2,3,3,4) | Details |
| 4060158 | Singh SV, Awasthi YC: Inhibition of human glutathione S-transferases by 2,4-dichlorophenoxyacetate (2,4-D) and 2,4,5-trichlorophenoxyacetate (2,4,5-T). Toxicol Appl Pharmacol. 1985 Nov;81(2):328-36. |
81(1,1,1,1) | Details |
| 18436336 | Peixoto FP, Gomes-Laranjo J, Vicente JA, Madeira VM: Comparative effects of the herbicides dicamba, 2,4-D and paraquat on non-green potato tuber calli. J Plant Physiol. 2008 Jul 31;165(11):1125-33. Epub 2008 Apr 23. Paraquat slightly inhibited glutathione S-transferase (GST), whereas 2,4-D and dicamba promoted significant activation. |
31(0,1,1,1) | Details |
| 1852715 | Santagostino A, Leone MP, Maci R, Casale A, Marabini L: Effects of phenoxyacetic acid herbicides on chicken embryo liver drug metabolizing enzymes. Pharmacol Toxicol. 1991 Feb;68(2):110-4. The higher dose of MCPA increased NADPH-cytochrome P450 reductase. 2,4-D treatment increased by activity of glutathione-S-transferases in the hepatic post-microsomal fraction while MCPA increased them at the lower dose and significantly reduced them at the higher. |
31(0,1,1,1) | Details |
| 8368864 | Evangelista de Duffard AM, Fabra de Peretti A, Castro de Cantarini S, Duffard R: Effects of 2,4-dichlorophenoxyacetic acid butyl ester on chick liver. . Arch Environ Contam Toxicol. 1993 Aug;25(2):204-11. On the other hand, the microsomal and cytosolic glutathione S-transferases activities remained unchanged, even though in vitro studies 2,4-D ester caused a decrease of the enzyme activities with an I50 value of 0.2 mM. |
7(0,0,1,2) | Details |
| 20138240 | Park K, Park J, Kim J, Kwak IS: Biological and molecular responses of Chironomus riparius (Diptera, Chironomidae) to herbicide 2,4-D (2,4-dichlorophenoxyacetic acid). Comp Biochem Physiol C Toxicol Pharmacol. 2010 May;151(4):439-46. Epub 2010 Feb 4. Furthermore, we evaluated the molecular and biochemical responses of biomarker genes such as gene expression of heat shock proteins (HSPs), ferritins and glutathione S-transferases (GSTs) in C. riparius exposed to 2,4-D for 24h. |
6(0,0,1,1) | Details |
| 16906522 | Celik I, Tuluce Y, Isik I: Influence of subacute treatment of some plant growth regulators on serum marker enzymes and erythrocyte and tissue antioxidant defense and lipid peroxidation in rats. J Biochem Mol Toxicol. 2006;20(4):174-82. This study aims to investigate the effects of the plant growth regulators (PGRs) (2,3,5-triiodobenzoic acid (TIBA), Naphthaleneacetic acid (NAA), and 2,4-dichlorofenoxyacetic acid (2,4-D)) on serum marker enzymes (aspartate aminotransferase (AST), alanin aminotransferase (ALT), phosphokinase (CPK), and lactate dehydrogenase (LDH)), antioxidant defense systems (GSH), glutathione reductase (GR), superoxide dismutase (SOD), glutathione-S-transferase (GST), and catalase (CAT)), and lipid peroxidation content (malondialdehyde = MDA) in various tissues of rats. 50 and 100 ppm of PGRs as drinking water were administered orally to rats (Sprague-Dawley albino) ad libitum for 25 days continuously. |
6(0,0,1,1) | Details |
| 6624478 | Hietanen E, Linnainmaa K, Vainio H: Effects of phenoxyherbicides and on the hepatic and intestinal biotransformation activities in the rat. Acta Pharmacol Toxicol. 1983 Aug;53(2):103-12. Both 2,4-D and MCPA increased the hepatic epoxide hydrolase activity and decreased the hepatic glutathione S-transferase activity. |
6(0,0,1,1) | Details |
| 18000851 | Celik I, Tuluce Y: Determination of toxicity of subacute treatment of some plant growth regulators on rats. Environ Toxicol. 2007 Dec;22(6):613-9. The effects of some plant growth regulators (PGRs), 2,3,5-triiodobenzoic acid (TIBA), Naphthaleneacetic acid (NAA) and 2,4-Dichlorofenoxyacetic acid (2,4-D), at sublethal concentrations on antioxidant defense system peroxidases (GPx), (GSH), glutathione reductase (GR), glutathione-S-transferase (GST) and catalase (CAT)], immune potential enzymes [adenosine deaminase (ADA) and myeloperoxidase (MPO)], and lipid peroxidation content [Malondialdehyde, (MDA)] were investigated in lung and speen tissues of rats. |
6(0,0,1,1) | Details |
| 3358263 | Vessey DA, Boyer TD: Characterization of the activation of rat liver glutathione S-transferases by nonsubstrate ligands. Toxicol Appl Pharmacol. 1988 Apr;93(2):275-80. Examination of the organic peroxidase activity of the enzyme revealed inhibition by 2,4,5-T and 2,4-D rather than activation. |
2(0,0,0,2) | Details |