| Name | IgE |
|---|---|
| Synonyms | IGHE; Ig epsilon chain C region; IgE; immunoglobulin heavy constant epsilon; Ig epsilon chain C regions; IgEs; immunoglobulin heavy constant epsilons |
| Name | 2,4-D |
|---|---|
| CAS | 2-(2,4-dichlorophenoxy)acetic acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7161824 | Cushman JR, Street JC: Allergic hypersensitivity to the herbicide 2,4-D in BALB/c mice. J Toxicol Environ Health. 1982 Oct-Nov;10(4-5):729-41. Specific IgE was determined with the rat passive cutaneous anaphylaxis test using a conjugate of 2,4-D with bovine serum albumin for challenge. |
113(1,2,2,3) | Details |
| 19467290 | Fukuyama T, Tajima Y, Ueda H, Hayashi K, Shutoh Y, Harada T, Kosaka T: Allergic reaction induced by dermal and/or respiratory exposure to low-dose phenoxyacetic acid, organophosphorus, and pesticides. Toxicology. 2009 Jul 10;261(3):152-61. Epub 2009 May 23. One day post-challenge, the mice were processed to obtain biologic materials for use in assays of total IgE levels in serum and bronchoalveolar lavage fluid (BALF); differential cell counts and chemokine levels in BALF; lymphocyte counts and surface antigen expression on B-cells within regional lymph nodes (LNs); and, ex situ cytokine production by cells from these LNs. 2,4-D-induced immune responses characteristic of immediate-type respiratory reactions, as evidenced by increased total IgE levels in both serum and BALF; an influx of eosinophils, neutrophils, and chemokines (MCP-1, eotaxin, and MIP-1beta) in BALF; increased surface antigen expression on B-cells IgE and MHC class II production) in both auricular and the lung-associated LNs; and increased Th2 cytokine production (IL-4, IL-5, IL-10, and IL-13) in both auricular and the lung-associated LN cells. |
31(0,1,1,1) | Details |
| 20219652 | Fukuyama T, Tajima Y, Ueda H, Hayashi K, Shutoh Y, Harada T, Kosaka T: A method for measuring mouse respiratory allergic reaction to low-dose chemical exposure to allergens: An environmental chemical of uncertain allergenicity, a typical contact allergen and a non-sensitizing irritant. Toxicol Lett. 2010 Feb 26. Our aim was to improve a method for detecting respiratory hypersensitivity by testing three confirmed respiratory allergens (trimellitic anhydride [TMA], phthalic anhydride [PA] and toluene diisocyanate [TDI]), an environmental chemical of uncertain allergenicity (2,4-d-butyl [DB]), a confirmed contact allergen (2,4-dinitrochlorobenzene [DNCB]) and a standard irritant [SDS]). One day post-challenge, samples were taken from the mice to assay for total immunoglobulin (IgE and IgG (1)) levels in serum and bronchoalveolar lavage fluid (BALF); differential cell counts and cytokine/chemokine levels in BALF; lymphocyte counts and surface antigen expression on B-cells within lung-associated lymph nodes (LNs); ex situ cytokine production by cells from these LNs; and gene expression in BALF (CCR3) and LNs (CCR4, STAT6 and GATA-3). |
2(0,0,0,2) | Details |