| Name | organic anion transporter 3 |
|---|---|
| Synonyms | OAT 3; OAT3; Organic anion transporter 3; SLC22A8; Solute carrier family 22 (organic anion transporter) member 8; Solute carrier family 22 member 8; Solute carrier family 22 member 8 variant; hOAT3… |
| Name | 2,4-D |
|---|---|
| CAS | 2-(2,4-dichlorophenoxy)acetic acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17255469 | Nozaki Y, Kusuhara H, Kondo T, Hasegawa M, Shiroyanagi Y, Nakazawa H, Okano T, Sugiyama Y: Characterization of the uptake of organic anion transporter (OAT) 1 and OAT3 substrates by human kidney slices. J Pharmacol Exp Ther. 2007 Apr;321(1):362-9. Epub 2007 Jan 25. In the present study, the uptake of some organic anions was characterized in kidney slices from human intact renal cortical tissues: hOAT1 and hOAT3 substrates (PAH) and 2,4-dichlorophenoxyacetate (2,4-D)] and hOAT3 substrates [benzylpenicillin (PCG), (DHEAS), and (ES)]. |
91(1,1,2,6) | Details |
| 15958719 | Lowes S, Sykes D, Breen CM, Ragone LJ, Miller DS: Multiple components of 2,4-dichlorophenoxyacetic acid uptake by rat choroid plexus. J Pharmacol Exp Ther. 2005 Oct;315(1):136-43. Epub 2005 Jun 15. The -dependent component of 2,4-D uptake coincided with the PAH-sensitive component, indicating uptake mediated by organic anion transporter subtype (Oat) 3. |
81(1,1,1,1) | Details |
| 15389674 | Nagata Y, Kusuhara H, Imaoka T, Endou H, Sugiyama Y: Involvement of rat organic anion transporter 3 in the uptake of an organic herbicide, 2,4-dichlorophenoxyacetate, by the isolated rat choroid plexus. J Pharm Sci. 2004 Nov;93(11):2724-32. The purpose of the present study is to examine whether organic anion transporter 3 (Oat3; Slc22a8) is solely responsible for the uptake of 2,4-D by the isolated rat choroid plexus (CP). |
7(0,0,1,2) | Details |
| 12660303 | Hasegawa M, Kusuhara H, Endou H, Sugiyama Y: Contribution of organic anion transporters to the renal uptake of anionic compounds and nucleoside derivatives in rat. J Pharmacol Exp Ther. 2003 Jun;305(3):1087-97. Epub 2003 Mar 26. Our previous kinetic analyses have shown that rat organic anion transporter 1 (rOat1; Slc22a6) and rOat3 (Slc22a8) are responsible for the renal uptake of and respectively. Transfection of rOat1 resulted in an increase of the uptake of temocaprilat (Km = 0.56 microM), 2,4-dichlorophenoxyacetate (2,4-D; Km = 10 microM), and 3'-azido-3'- (AZT; Km = 43 microM). rOat3-expressing cells showed significant uptake of temocaprilat (Km = 1.4 microM), (Km = 5.3 microM), (DHEAS; Km = 12 microM), and benzylpenicillin (PCG; Km = 85 microM). |
1(0,0,0,1) | Details |