Protein Information

Name aspartate aminotransferase
Synonyms Aspartate Aminotransferase 1; GIG18; GOT 1; GOT1; Aspartate aminotransferase; Glutamate oxaloacetate transaminase 1; Transaminase A; Aspartate aminotransferases…

Compound Information

Name 2,4-D
CAS 2-(2,4-dichlorophenoxy)acetic acid

Reference List

PubMed Abstract RScore(About this table)
1726651 Paulino CA, Palermo-Neto J: Effects of acute 2,4-dichlorophenoxyacetic acid intoxication on some rat serum components and enzyme activities. Braz J Med Biol Res. 1991;24(2):195-8.

The present study was undertaken to investigate the effects of acute 2,4-dichlorophenoxyacetic acid (2,4-D) intoxication (0.6 g/kg, po) on lactate dehydrogenase, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, amylase, creatinine, glucose, total protein and albumin levels in rats.
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8540221 Paulino CA, Palermo-Neto J: Effects of acute 2,4-dichlorophenoxyacetic acid on cattle serum components and enzyme activities. Vet Hum Toxicol. 1995 Aug;37(4):329-32.

The acute toxicity of 2,4-dichlorophenoxyacetic acid (2,4-D) was studied in cattle.
Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (AP), O-glutamyl transferase (O-GT), creatine kinase (CK), lactate dehydrogenase (LDH) activities and urea, creatinine, glucose, total proteins and albumin levels were determined at intervals after dosing.
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9928676 Charles JM, Leeming NM: Chronic dietary toxicity study on 2,4-dichlorophenoxybutyric acid in the dog. Toxicol Sci. 1998 Nov;46(1):134-42.


Treatment-related findings included reductions in body weight gain and food consumption, and minor increases in inorganic phosphorus, blood urea nitrogen, creatinine, aspartate aminotransferase, and alanine aminotransferase.
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9565231 Morgulis MS, Oliveira GH, Dagli ML, Palermo-Neto J: Acute 2,4-dichlorophenoxyacetic acid intoxication in broiler chicks. Poult Sci. 1998 Apr;77(4):509-15.


The acute toxicity of 2,4-dichlorophenoxyacetic acid (2,4-D), a herbicide, was studied in chicks dosed with 100, 300, 500, or 600 mg 2,4-D/kg BW, by the oral route.
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8888538 Paulino CA, Guerra JL, Oliveira GH, Palermo-Neto J: Acute, subchronic and chronic 2,4-dichlorophenoxyacetic acid (2,4-D) intoxication in rats. Vet Hum Toxicol. 1996 Oct;38(5):348-52.

After acute exposure, the herbicide decreased locomotor activity and induced ataxia, sedation, muscular weakness (mainly of the hind quarters) and gasping for breath; increased aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), alkaline phosphatase (AP), amylase activities and creatinine levels; decreased total protein (TP) and glucose levels; and increased hematocrit values.
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2627000 Somlyay IM, Varnagy LE: Changes in blood plasma biochemistry of chicken embryos exposed to various pesticide formulations. Acta Vet Hung. 1989;37(1-2):179-83.

Wofatox 50 EC (methylparathion 50%), Nevifosz 50 EC (phosmethylan 50%), Kolfugo 25 FW (carbendazim 25%) and Dikamin D (2,4-D 40%) pesticide formulations were used as test material.
Blood samples were obtained and some plasma parameters including packed cell volume (PCV), total protein, glucose, cholesterol, aspartate aminotransferase (AST), lactate dehydrogenase (LDH) and plasma pseudocholinesterase (PChE) activities were evaluated.
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16906522 Celik I, Tuluce Y, Isik I: Influence of subacute treatment of some plant growth regulators on serum marker enzymes and erythrocyte and tissue antioxidant defense and lipid peroxidation in rats. J Biochem Mol Toxicol. 2006;20(4):174-82.

This study aims to investigate the effects of the plant growth regulators (PGRs) (2,3,5-triiodobenzoic acid (TIBA), Naphthaleneacetic acid (NAA), and 2,4-dichlorofenoxyacetic acid (2,4-D)) on serum marker enzymes (aspartate aminotransferase (AST), alanin aminotransferase (ALT), creatine phosphokinase (CPK), and lactate dehydrogenase (LDH)), antioxidant defense systems (reduced glutathione (GSH), glutathione reductase (GR), superoxide dismutase (SOD), glutathione-S-transferase (GST), and catalase (CAT)), and lipid peroxidation content (malondialdehyde = MDA) in various tissues of rats. 50 and 100 ppm of PGRs as drinking water were administered orally to rats (Sprague-Dawley albino) ad libitum for 25 days continuously.
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