| Name | connective tissue growth factor |
|---|---|
| Synonyms | CCN 2; CCN2; CTGF; Connective tissue growth factor; Connective tissue growth factor precursor; FISP 12 protein; HCS24; Hypertrophic chondrocyte specific protein 24… |
| Name | SMA |
|---|---|
| CAS | sodium 2-chloroacetate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19080126 | Liu DG, Wang TM: Role of connective tissue growth factor in experimental radiation nephropathy in rats. Chin Med J. 2008 Oct 5;121(19):1925-31. |
11(0,0,0,11) | Details |
| 19014648 | Kapoor M, Liu S, Huh K, Parapuram S, Kennedy L, Leask A: Connective tissue growth factor promoter activity in normal and wounded skin. Clin Sci. 2009 Sep 14;117(11):375-86. |
10(0,0,0,10) | Details |
| 18784150 | Silver RM, Wells AU: Histopathology and bronchoalveolar lavage. PLoS One. 2009 Oct 13;4(10):e7438. Analysis of BALF suggests an imbalance between pro-fibrotic and anti-fibrotic factors, e.g. an overabundance of TGF-beta, connective tissue growth factor (CTGF), PDGF, leucotriene B4, etc. and in some cases a deficiency of hepatocyte growth factor, (15-HETE), lipoxin A, etc. |
1(0,0,0,1) | Details |
| 20002896 | Klass BR, Branford OA, Grobbelaar AO, Rolfe KJ: The effect of a constituent of green tea, on transforming growth factor-beta1-stimulated wound contraction. J Am Soc Nephrol. 2007 Dec;18(12):3110-8. Epub 2007 Nov 14. appears to affect the role that TGF-beta1 plays in fibroblast populated collagen gel contraction and this seems to be through both myofibroblast differentiation and connective tissue growth factor gene expression and reduces the expression of collagen type I gene regulation. |
1(0,0,0,1) | Details |
| 19916059 | Liu S, Taghavi R, Leask A: Connective tissue growth factor is induced in bleomycin-induced skin scleroderma. J Cell Commun Signal. 2009 Mar;3(1):61-4. Epub 2009 Apr 22. |
10(0,0,0,10) | Details |
| 19112898 | Zuo C, Xie XS, Deng Y, Fan JM: [Effect of Astragalus mongholicus on expression of connective tissue growth factor in kidney of SD rats with unilateral ureteral obstruction]. Fibrogenesis Tissue Repair. 2008 Oct 13;1(1):3. |
8(0,0,0,8) | Details |
| 18610632 | Liu X, Wu W, Chen H: [Effects of CTGF gene silencing on the proliferation and myofibroblast differentiation of human lung fibroblasts]. Nephrol Dial Transplant. 2009 May;24(5):1406-16. Epub 2008 Dec 4. |
8(0,0,0,8) | Details |
| 17651610 | Long X, Xiong SD, Xiong WN, Xu YJ, Zhang ZX, Cao Y, Chen J, Xu XH: [Losartan inhibited angiotensin induced human lung fibroblast transformation and collagen synthesis]. Invest Ophthalmol Vis Sci. 2008 Sep;49(9):3955-60. Epub 2008 Apr 17. OBJECTIVE: To observe the induction of cell transdifferentiation, connective tissue growth factor (CTGF) expression and collagen production of human lung fibroblast (HLF) by angiotensin II (Ang II), and to investigate the inhibitory effect of Ang II receptor antagonist-losartan on this process. |
7(0,0,0,7) | Details |
| 18790236 | Luo GH, Lu YP, Song J, Yang L, Shi YJ, Li YP: Inhibition of connective tissue growth factor by small interfering RNA prevents renal fibrosis in rats undergoing chronic allograft nephropathy. Biosci Biotechnol Biochem. 2010 Mar 23;74(3):477-83. Epub 2010 Mar 7. |
7(0,0,0,7) | Details |
| 18787407 | Mantoni TS, Schendel RR, Rodel F, Niedobitek G, Al-Assar O, Masamune A, Brunner TB: Stromal SPARC expression and patient survival after chemoradiation for non-resectable pancreatic adenocarcinoma. Zhong Yao Cai. 2008 Aug;31(8):1185-90. Experimental design: Immunohistochemical expression of SPARC, CTGF, TGFbeta1, phospho-Akt, survivin and alpha-SMA was analyzed prior to chemoradiation in 58 locally advanced pancreatic cancer (LAPC) biopsy specimens. |
1(0,0,0,1) | Details |
| 20208363 | Lim CS, Kim EY, Lee HS, Soh Y, Sohn Y, Kim SY, Sohn NW, Jung HS, Kim YB: Protective effects of Cinnamomum cassia Blume in the fibrogenesis of activated HSC-T6 cells and dimethylnitrosamine-induced acute liver injury in SD rats. Zhonghua Shao Shang Za Zhi. 2009 Dec;25(6):454-9. CCE significantly reduced the expression of alpha-smooth muscle actin (alpha-SMA), connective tissue growth factor (CTGF), transforming growth factor beta (TGF-beta1), and tissue inhibitor of metalloproteinase-1 (TIMP-1). |
1(0,0,0,1) | Details |
| 19588762 | Li Z, Li SR, Liu JY, Dai X, Tao L: [To transdifferentiate human hypertrophic scar fibroblasts induced by connective tissue growth factor mediated transforming growth factor-beta 1 in vitro]. Zhonghua Shao Shang Za Zhi. 2009 Feb;25(1):49-52. |
7(0,0,0,7) | Details |
| 17718418 | Wang W, Shi YJ, Zhang L, Li Q, Qiu J, Tu ZD, Ye F, Bu H: [Effect of synthesized polypeptide (P16) on inhibiting cell transdifferentiation and fibrosis induced by connective tissue growth factor]. Wound Repair Regen. 2010 Jan-Feb;18(1):80-8. Epub 2009 Dec 11. |
7(0,0,0,7) | Details |
| 19349682 | Wang L, Ning W, Tao L, Wang L, Peng Z: [Dynamic observation of enalapril on the expression of TGF-beta1, CTGF, Smad7 and alpha-SMA in rats with unilateral ureteral obstruction]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2009 Mar;34(3):252-8. |
7(0,0,0,7) | Details |
| 19957515 | Xu YF, Wan JX, Jiang DW: [Effects of bone morphogenic protein-7 on transdifferentiation and the expression of connective tissue growth factor of human renal tubular epithelial cells induced by transforming growth factor-beta1]. Food Chem Toxicol. 2008 Sep;46(9):3122-31. Epub 2008 Jul 10. |
6(0,0,0,6) | Details |
| 19296469 | Van Hul NK, Abarca-Quinones J, Sempoux C, Horsmans Y, Leclercq IA: Relation between liver progenitor cell expansion and extracellular matrix deposition in a CDE-induced murine model of chronic liver injury. Transplant Proc. 2008 Sep;40(7):2365-9. By contrast, at day 3 there was a rapid burst in the expression of components of the ECM, collagen I and laminin, as well as in alpha-SMA and connective tissue growth factor expression. |
1(0,0,0,1) | Details |
| 19065061 | Ren X, Guan G, Liu G, Liu G: Irbesartan ameliorates diabetic nephropathy by reducing the expression of connective tissue growth factor and alpha-smooth-muscle actin in the tubulointerstitium of diabetic rats. Phytomedicine. 2010 Mar;17(3-4):282-8. Epub 2009 Jun 12. |
6(0,0,0,6) | Details |
| 19670427 | Tong Z, Chen R, Alt DS, Kemper S, Perbal B, Brigstock DR: Susceptibility to liver fibrosis in mice expressing a connective tissue growth factor transgene in hepatocytes. Hepatology. 2009 May;49(5):1625-35. |
6(0,0,0,6) | Details |
| 19816049 | Xu Y, Wan J, Jiang D, Wu X: BMP-7 blocks the cyclosporine-A-induced epithelial-to-mesenchymal transition in renal tubular epithelial cells. 943. AIMS: The nephrotoxic side effects of cyclosporine A (CsA) are partly due to induction of the epithelial-to-mesenchymal transition (EMT), possibly through upregulation of connective tissue growth factor (CTGF). |
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| 19024302 | You GQ, Fu P, Xie XS, Liu F, Li J: [Effects of piperazine on TGF-beta1-induced renal interstitial fibroblast activation]. Cancer Biol Ther. 2008 Nov 24;7(11). The protein expression levels of a-smooth muscle actin (alpha-SMA), connective tissue growth factor (CTGF) induced by TGF-beta1 were evaluated by immunocytochemistry. |
4(0,0,0,4) | Details |
| 17951996 | Liu BC, Li MX, Zhang JD, Liu XC, Zhang XL, Phillips AO: Inhibition of integrin-linked kinase via a siRNA expression plasmid attenuates connective tissue growth factor-induced human proximal tubular epithelial cells to mesenchymal transition. Sichuan Da Xue Xue Bao Yi Xue Ban. 2008 Sep;39(5):736-9 |
4(0,0,0,4) | Details |
| 18991162 | Nan YM, Fu N, Wu WJ, Liang BL, Wang RQ, Zhao SX, Zhao JM, Yu J: prevents nutritional fibrosis and steatohepatitis in mice. Am J Nephrol. 2008;28(1):143-51. Epub 2007 Oct 19. The effect of was assessed by comparing the severity of hepatic fibrosis in liver sections, the activation of hepatic stellate cells (HSCs) and the expression of TGF-beta1 and connective tissue growth factor (CTGF). |
4(0,0,0,4) | Details |
| 19781193 | Ding Z, Chen ZS, Chen XL, Guo H, Gong NQ: [Inducing of epithelial mesenchymal transition of HK-2 cells by connective tissue growth factor in vitro]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2007 Jul;38(4):590-4. |
4(0,0,0,4) | Details |
| 20193171 | Liu JQ, Hu DH, Zhang ZF, Guan H, She T, Zhang J, Bai XZ: [Effects of interferon-gamma on the transforming growth factor beta/Smad pathway in keloid-derived fibroblasts]. Transplant Proc. 2008 Oct;40(8):2790-4. The expression level of mRNA and protein of connective tissue growth factor (CTGF), alpha smooth muscle actin (alpha-SMA) protein and expression of alpha-SMA positive KFb were detected by real-time fluorescent quantitation RT-PCR (FQ-RT-PCR), Western blot and immunofluorescence cytochemical staining. (2) Another sample of KFb was obtained and treated with 10 ng/mL IFN-gamma. |
4(0,0,0,4) | Details |
| 19253820 | Li Q, Fan JM, Pu L, Li Z, Qin W, Su BH: [Effects of interferon-gamma on tubular epithelial-myofibroblast transdifferentiation in vitro]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2008 Nov;39(6):895-9 The expressions of a-smooth muscle actin (alpha-SMA) and connective tissue growth factor (CTGF) were detected by immunocytochemistry. |
4(0,0,0,4) | Details |
| 18291634 | Kennedy L, Shi-Wen X, Carter DE, Abraham DJ, Leask A: Fibroblast adhesion results in the induction of a matrix remodeling gene expression program. Matrix Biol. 2008 May;27(4):274-81. Epub 2008 Jan 26. In this report, we show that FAK is required for the expression of a cohort of mRNAs encoding ECM and matrix remodeling genes including CCN2, alpha-smooth muscle actin (SMA) and type I collagen. |
3(0,0,0,3) | Details |
| 19823586 | Xu SW, Liu S, Eastwood M, Sonnylal S, Denton CP, Abraham DJ, Leask A: Rac inhibition reverses the phenotype of fibrotic fibroblasts. . J Nephrol. 2009 May-Jun;22(3):403-10. Fibroblasts from lesional areas of scleroderma patients possess elevated abilities to contract matrix and produce alpha-smooth muscle actin (alpha-SMA), type I collagen and CCN2 (connective tissue growth factor, CTGF). |
3(0,0,0,3) | Details |
| 18929865 | Luo GH, Lu YP, Yang L, Song J, Shi YJ, Li YP: Epithelial to mesenchymal transformation in tubular epithelial cells undergoing anoxia. Rheumatology. 2008 Oct;47 Suppl 5:v62-4. After 6, 12, 24, 48, and 72 hours, the expressions of connective tissue growth factor (CTGF) mRNA and protein were measured by real-time RT-PCR and Western blot, respectively. |
3(0,0,0,3) | Details |
| 18929863 | Song J, Lu YP, Luo GH, Yang L, Ma X, Xia QJ, Shi YJ, Li YP: Effects of mycophenolate mofetil on chronic allograft nephropathy by affecting RHO/ROCK signal pathways. Eur J Clin Invest. 2008 Jun;38(6):410-20. Expressions of alpha-smooth muscle actin (alpha-SMA) and connective tissue growth factor (CTGF) were observed by immunohistochemistry. |
3(0,0,0,3) | Details |
| 19208517 | Guo GH, Tan DM, Zhu PA, Liu F: Hepatitis B virus X protein promotes proliferation and upregulates TGF-beta1 and CTGF in human hepatic stellate cell line, LX-2. Zhonghua Jie He He Hu Xi Za Zhi. 2007 Apr;30(4):273-8. |
3(0,0,0,3) | Details |
| 18274641 | Wang W, Liu F, Chen N: Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonists attenuate the profibrotic response induced by TGF-beta1 in renal interstitial fibroblasts. Mediators Inflamm. 2007;2007:62641. METHODS: In rat renal interstitial fibroblasts (NRK/49F), the mRNA expression of TGF-beta1-induced alpha-smooth muscle actin (alpha-SMA), connective tissue growth factor (CTGF), fibronectin (FN) and collagen type III (Col III) were observed by reverse transcriptase-polymerase chain reaction (RT-PCR). |
3(0,0,0,3) | Details |
| 19056781 | Dudas PL, Argentieri RL, Farrell FX: BMP-7 fails to attenuate TGF-beta1-induced epithelial-to-mesenchymal transition in human proximal tubule epithelial cells. Nephron Exp Nephrol. 2010;114(1):e23-31. Epub 2009 Oct 9. METHODS: EMT was determined by quantitative real-time PCR analysis of e-cadherin, vimentin, CTGF and TGF-beta1 transcript expression and immunocytochemical analysis of ZO-1 and alpha-smooth muscle actin (alpha-SMA) protein expression following TGF-beta1 treatment in RPTEC and HK-2 cells. |
3(0,0,0,3) | Details |
| 19877031 | Bogatkevich GS, Ludwicka-Bradley A, Silver RM: Dabigatran, a direct thrombin inhibitor, demonstrates antifibrotic effects on lung fibroblasts. Arthritis Rheum. 2009 Nov;60(11):3455-64. Connective tissue growth factor (CTGF) and type I collagen expression was analyzed on Western blots. |
3(0,0,0,3) | Details |
| 19524418 | Li GS, Jiang WL, Tian JW, Qu GW, Zhu HB, Fu FH: In vitro and in vivo antifibrotic effects of on experimental liver fibrosis. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2008 Apr;25(2):407-12. In carbon tetrachloride (CCL (4))-induced rat liver fibrosis model, determined biochemical indicator, liver fibrosis grade and histopathological changes, immunohistochemical detected liver TGF-beta1 and CTGF expression. |
3(0,0,0,3) | Details |
| 17907149 | Manetti M, Neumann E, Milia AF, Tarner IH, Bechi P, Matucci-Cerinic M, Ibba-Manneschi L, Muller-Ladner U: Severe fibrosis and increased expression of fibrogenic cytokines in the gastric wall of systemic sclerosis patients. Liver Int. 2009 Aug;29(7):997-1009. Epub 2009 Apr 28. Tissue sections were either stained with Masson's trichrome or by immunohistochemistry and analyzed for the expression of types I, III, and IV collagen, alpha-smooth muscle actin (alpha-SMA), transforming growth factor beta (TGFbeta), connective tissue growth factor (CTGF), and endothelin 1 (ET-1). |
2(0,0,0,2) | Details |
| 19101551 | Ono A, Utsugi M, Masubuchi K, Ishizuka T, Kawata T, Shimizu Y, Hisada T, Hamuro J, Mori M, Dobashi K: redox regulates TGF-beta-induced fibrogenic effects through Smad3 activation. FEBS Lett. 2009 Jan 22;583(2):357-62. Epub 2008 Dec 25. Transforming growth factor-beta (TGF-beta) plays a pivotal role in the fibrogenic action involved in the induction of connective tissue growth factor (CTGF), extracellular matrix and fibroblast transformation. |
2(0,0,0,2) | Details |
| 19557718 | Xu Y, Wan J, Jiang D, Wu X: BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition in human renal proximal tubular epithelial cells. Am J Physiol Renal Physiol. 2008 Jul;295(1):F118-27. Epub 2008 Apr 30. The expression of alpha-smooth muscle actin (alpha-SMA), E-cadherin, fibronectin, collagen I and connective tissue growth factor (CTGF) was analyzed by immunofluorescence, reverse transcriptase polymerase chain reaction and Western blotting. |
2(0,0,0,2) | Details |
| 18003779 | Pradere JP, Klein J, Gres S, Guigne C, Neau E, Valet P, Calise D, Chun J, Bascands JL, Saulnier-Blache JS, Schanstra JP: LPA1 receptor activation promotes renal interstitial fibrosis. . Arthritis Rheum. 2007 Oct;56(10):3442-7. Furthermore, treatment of wild-type mice with the LPA1 antagonist Ki16425 similarly reduced fibrosis and significantly attenuated renal expression of the profibrotic cytokines connective tissue growth factor (CTGF) and transforming growth factor beta (TGFbeta). |
2(0,0,0,2) | Details |
| 18489401 | Latella G, Sferra R, Vetuschi A, Zanninelli G, D'Angelo A, Catitti V, Caprilli R, Gaudio E: Prevention of colonic fibrosis by Boswellia and Scutellaria extracts in rats with colitis induced by 2,4,5-trinitrobenzene 762. For immunohistochemical analysis, alpha-smooth muscle actin (alpha-SMA), collagen types I-III, connective tissue growth factor (CTGF), transforming growth factor-beta1 (TGF-beta1), Smad3, Smad7 and CD3 antibodies were used. |
2(0,0,0,2) | Details |
| 19384472 | Shiwen X, Rajkumar V, Denton CP, Leask A, Abraham DJ: Pericytes display increased CCN2 expression upon culturing. Zhonghua Yi Xue Za Zhi. 2009 Jun 16;89(23):1639-44. |
2(0,0,0,2) | Details |
| 19200168 | Latella G, Vetuschi A, Sferra R, Zanninelli G, D'Angelo A, Catitti V, Caprilli R, Flanders KC, Gaudio E: Smad3 loss confers resistance to the development of trinitrobenzene -induced colorectal fibrosis. Eur J Clin Invest. 2009 Feb;39(2):145-56. For immunohistochemistry, alpha-smooth muscle actin (alpha-SMA), collagen types I-III, TGF-beta1, connective tissue growth factor (CTGF), Smad3, Smad7, and CD3 antibodies were used. |
2(0,0,0,2) | Details |
| 20157767 | Li Y, Zhang J, Fang L, Luo P, Peng J, Du X: Lefty A attenuates the TGF-beta1-induced epithelial to mesenchymal transition of human renal proximal epithelial tubular cells. Mol Cell Biochem. 2010 Feb 16. The epithelial to mesenchymal transition (EMT) is a crucial event for renal fibrosis that can be elicited by TGF-beta1/Smads signaling and its downstream mediator connective tissue growth factor (CTGF). |
2(0,0,0,2) | Details |
| 19336420 | Ibba-Manneschi L, Manetti M, Milia AF, Miniati I, Benelli G, Guiducci S, Mecacci F, Mello G, Di Lollo S, Matucci-Cerinic M: Severe fibrotic changes and altered expression of angiogenic factors in maternal scleroderma: placental findings. Ann Rheum Dis. 2010 Feb;69(2):458-61. Epub 2009 Mar 30. The sections were stained with Masson's trichrome and phosphotungstic-acid-haematoxylin and immunostained for connective tissue growth factor (CTGF), alpha-smooth muscle actin (alpha-SMA), vascular endothelial growth factor (VEGF), placenta growth factor (PlGF) and receptors VEGFR-1 and VEGFR-2. |
2(0,0,0,2) | Details |
| 18421080 | Meyer-Ter-Vehn T, Katzenberger B, Han H, Grehn F, Schlunck G: Lovastatin inhibits TGF-beta-induced myofibroblast transdifferentiation in human tenon fibroblasts. Pharmacology. 2009;83(2):80-7. Epub 2008 Dec 9. METHODS: Human Tenon fibroblasts were grown in culture, pretreated with lovastatin, lovastatin and or specific inhibitors of farnesyl transferase or geranylgeranyl transferase and were stimulated with TGF-beta1. alpha-Smooth muscle actin (alpha-SMA) and connective tissue growth factor (CTGF) transcription were assessed by real-time PCR. alpha-SMA protein expression and localization were studied by Western blot and confocal immunofluorescence microscopy. |
2(0,0,0,2) | Details |
| 18662738 | Wojcikowski K, Wohlmuth H, Johnson DW, Gobe G: Dioscorea villosa (wild yam) induces chronic kidney injury via pro-fibrotic pathways. Hepatobiliary Pancreat Dis Int. 2009 Feb;8(1):59-64. Macrophage infiltration (ED-1), epithelial-to-mesenchymal transdifferentiation or activation of fibroblasts (vimentin, alpha-SMA), and pro-fibrotic growth factors (TGFss1, CTGF) were assessed using IHC. |
2(0,0,0,2) | Details |
| 19578024 | Parapuram SK, Chang B, Li L, Hartung RA, Chalam KV, Nair-Menon JU, Hunt DM, Hunt RC: Differential effects of TGFbeta and vitreous on the transformation of retinal pigment epithelial cells. J Cell Commun Signal. 2009 Nov 15. The levels of mRNA for genes indicative of myofibroblast differentiation (alpha-SMA and CTGF) were increased by treatment with TGFbeta but suppressed by vitreous. |
2(0,0,0,2) | Details |
| 19422482 | Latella G, Vetuschi A, Sferra R, Catitti V, D'Angelo A, Zanninelli G, Flanders KC, Gaudio E: Targeted disruption of Smad3 confers resistance to the development of dimethylnitrosamine-induced hepatic fibrosis in mice. Invest Ophthalmol Vis Sci. 2009 Dec;50(12):5965-74. Epub 2009 Jul 2. For IHC, alpha-smooth muscle actin (alpha-SMA), collagen types I-III, TGF-beta1, connective tissue growth factor (CTGF), Smad3, Smad7 and CD3 antibodies were used. |
2(0,0,0,2) | Details |
| 18448597 | Huang XR, Chung AC, Wang XJ, Lai KN, Lan HY: Mice overexpressing latent TGF-beta1 are protected against renal fibrosis in obstructive kidney disease. Scand J Gastroenterol. 2009;44(3):358-65. Further studies showed that inhibition of renal fibrosis in Tg mice was associated with a significant reduction in renal TGF-beta1 and CTGF (60% reduced, P < 0.05), an increase in renal Smad7, a suppression of TSP-1 (a critical factor for TGF-beta1 activation), and an inhibition of Smad2/3 activation (all P < 0.001). |
1(0,0,0,1) | Details |
| 19096081 | Chung AC, Huang XR, Zhou L, Heuchel R, Lai KN, Lan HY: Disruption of the Smad7 gene promotes renal fibrosis and inflammation in unilateral ureteral obstruction (UUO) in mice. Nephrol Dial Transplant. 2009 May;24(5):1443-54. Epub 2008 Dec 18. This was associated with a significant upregulation of renal TGF-beta1 and CTGF and activation of Smad2/3. |
1(0,0,0,1) | Details |
| 18955978 | Wang J, Dodd C, Shankowsky HA, Scott PG, Tredget EE: Deep dermal fibroblasts contribute to hypertrophic scarring. Lab Invest. 2008 Dec;88(12):1278-90. Epub 2008 Oct 27. In quantitative RT-PCR, the cells from the deeper layers had higher CTGF and HSP47 mRNA levels compared to those from superficial layers. |
1(0,0,0,1) | Details |
| 19371232 | Lubel JS, Herath CB, Tchongue J, Grace J, Jia Z, Spencer K, Casley D, Crowley P, Sievert W, Burrell LM, Angus PW: Angiotensin-(1-7), an alternative metabolite of the renin-angiotensin system, is up-regulated in human liver disease and has antifibrotic activity in the bile-duct-ligated rat. Zhonghua Bing Li Xue Za Zhi. 2009 Jul;38(7):462-5. In BDL rats, Ang-(1-7) improved fibrosis stage and collagen Picrosirius Red staining, and reduced content, together with decreased gene expression of collagen 1A1, alpha-SMA (smooth muscle actin), VEGF (vascular endothelial growth factor), CTGF (connective tissue growth factor), ACE and mas [the Ang-(1-7) receptor]. |
1(0,0,0,1) | Details |