Protein Information

Name ERK2
Synonyms ERK; P40; ERK 2; ERK2; ERT 1; ERT1; Extracellular signal regulated kinase 2; MAP kinase 2…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
17884089 Wakisaka O, Takahashi N, Shinohara T, Ooie T, Nakagawa M, Yonemochi H, Hara M, Shimada T, Saikawa T, Yoshimatsu H: Hyperthermia treatment prevents angiotensin II-mediated atrial fibrosis and fibrillation via induction of heat-shock protein 72. J Mol Cell Cardiol. 2007 Nov;43(5):616-26. Epub 2007 Aug 16.


HT induced the expression of HSP72, which was associated with the attenuation of AII-induced extracellular signal-regulated kinase (ERK1/ERK2) phosphorylation, alpha-smooth muscle actin (alpha-SMA) expression, transforming growth factor-beta (1) secretion, collagen synthesis, and expression of collagen type I and tissue inhibitor of metalloproteinases-1.
1(0,0,0,1) Details
19819988 Chang SF, Chang TK, Peng HH, Yeh YT, Lee DY, Yeh CR, Zhou J, Cheng CK, Chang CA, Chiu JJ: BMP-4 induction of arrest and differentiation of osteoblast-like cells via p21 CIP1 and p27 KIP1 regulation. Mol Endocrinol. 2009 Nov;23(11):1827-38. Epub 2009 Oct 9.

The extracellular matrix/beta (3) integrin/ focal adhesion kinase/Shc/ERK2 signaling pathway is involved in these BMP-4-induced responses in osteoblast-like cells.
Using specific small interfering RNA (siRNA), we found that BMP-4-induced G (0)/G (1) arrest, and p21 (CIP1) and p27 (KIP1) expressions were mediated by BMP receptor type IA (BMPRIA)-specific Sma- and Mad-related protein (Smad) 1/5.
1(0,0,0,1) Details
19781193 Ding Z, Chen ZS, Chen XL, Guo H, Gong NQ: [Inducing of epithelial mesenchymal transition of HK-2 cells by connective tissue growth factor in vitro]. Zhonghua Bing Li Xue Za Zhi. 2009 Jul;38(7):462-5.


Direct immunofluorescence staining and immunohistochemistry were used to evaluate the E-cadherin, Vimentin, alpha-SMA and ERK2 in cells.
3(0,0,0,3) Details
19484746 Takeda K, Okamoto M, de Langhe S, Dill E, Armstrong M, Reisdorf N, Irwin D, Koster M, Wilder J, Stenmark KR, West J, Klemm D, Gelfand EW, Nozik-Grayck E, Majka SM: Peroxisome proliferator-activated receptor-g agonist treatment increases septation and angiogenesis and decreases airway hyperresponsiveness in a model of experimental neonatal chronic lung disease. Anat Rec. 2009 Jul;292(7):1045-61.


Following hyperoxic exposure (HE) animals were returned to RA until postnatal day (P) 13 or P41.
2(0,0,0,2) Details