Protein Information

Name beta catenin
Synonyms Beta catenin; CTNNB; CTNNB 1; CTNNB1; Catenin beta; Catenin beta 1; OK/SW cl.35; PRO2286…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
19335981 Li WT, He YW, Xiao ZH, Ma YB: [Effect of beta-catenin on the activation of hepatic stellate cells induced by transforming growth factor-beta1]. Zhonghua Gan Zang Bing Za Zhi. 2009 Mar;17(3):188-92.

8(0,0,0,8) Details
20015942 Lee YJ, Han HJ: Troglitazone ameliorates high glucose-induced EMT and dysfunction of SGLTs through PI3K/Akt, GSK-3{beta}, Snail1, and {beta}-catenin in renal proximal tubule cells. Am J Physiol Renal Physiol. 2009 Dec 16.

6(0,0,0,6) Details
18346908 Caraci F, Gili E, Calafiore M, Failla M, La Rosa C, Crimi N, Sortino MA, Nicoletti F, Copani A, Vancheri C: TGF-beta1 targets the GSK-3beta/beta-catenin pathway via ERK activation in the transition of human lung fibroblasts into myofibroblasts. Pharmacol Res. 2008 Apr;57(4):274-82. Epub 2008 Feb 9.

6(0,0,0,6) Details
19153880 Degreef I, De Smet L, Sciot R, Cassiman JJ, Tejpar S: Immunohistochemical evidence for Zic1 coexpression with beta-catenin in the myofibroblast of Dupuytren disease. Scand J Plast Reconstr Surg Hand Surg. 2009;43(1):36-40.

5(0,0,0,5) Details
20006464 Wu G, Tu Y, Jia R: The influence of fasudil on the epithelial-mesenchymal transdifferentiation of renal tubular epithelial cells from diabetic rats. Biomed Pharmacother. 2010 Feb;64(2):124-9. Epub 2009 Oct 23.


Expression of ROCK1, alpha-SMA, E-cadherin and the distribution of beta-catenin in rat renal cortex were revealed by immunohistochemistry.
5(0,0,0,5) Details
19900406 Du R, Huang C, Bi Q, Zhai Y, Xia L, Liu J, Sun S, Fan D: URG11 mediates hypoxia-induced epithelial-to-mesenchymal transition by modulation of E-cadherin and beta-catenin. Biochem Biophys Res Commun. 2010 Jan 1;391(1):135-41. Epub 2009 Nov 11.

4(0,0,0,4) Details
19462446 Hong JJ, Pan FY, Qian Y, Cheng LC, Zhang HX, Xue B, Li CJ: Overexpression of beta-catenin is responsible for the development of portal hypertension during liver cirrhosis. Anat Rec. 2009 Jun;292(6):818-26.

4(0,0,0,4) Details
18692477 Iriyama A, Iriyama T, Tamaki Y, Yanagi Y: Effects of white light on beta-catenin signaling pathway in retinal pigment epithelium. Biochem Biophys Res Commun. 2008 Oct 10;375(1):173-7. Epub 2008 Aug 8.

3(0,0,0,3) Details
20112425 Tang DJ, Dong SS, Ma NF, Xie D, Chen L, Fu L, Lau SH, Li Y, Li Y, Guan XY: Overexpression of eukaryotic initiation factor 5A2 enhances cell motility and promotes tumor metastasis in hepatocellular carcinoma. Hepatology. 2009 Nov 30.


Further study found that EIF5A2 was able to induce epithelial-mesenchymal transition (EMT), a key event in tumor invasion and metastasis, characterized by down-regulation of epithelial markers (E-cadherin and beta-catenin) and up-regulation of mesenchymal markers (fibronectin, N-cadherin, alpha-SMA, and vimentin).
1(0,0,0,1) Details
17684115 Dong YF, Soung do Y, Chang Y, Enomoto-Iwamoto M, Paris M, O'Keefe RJ, Schwarz EM, Drissi H: Transforming growth factor-beta and Wnt signals regulate chondrocyte differentiation through Twist1 in a stage-specific manner. Mol Endocrinol. 2007 Nov;21(11):2805-20. Epub 2007 Aug 7.

TGF-beta significantly induced beta-catenin in immature chondrocytes, whereas it repressed it in mature chondrocytes.
Our immunoprecipitation experiments showed that TGF-beta induced Sma- and Mad-related protein 3 interaction with T-cell factor 4 in immature chondrocytes, whereas it inhibited this interaction in mature chondrocytes.
1(0,0,0,1) Details
20179324 Gustafson B, Smith U: Activation of canonical Wingless-type MMTV integration site family (WNT) signaling in mature adipocytes increases &-{beta}catenin levels and leads to cell dedifferentiation and insulin resistance. J Biol Chem. 2010 Feb 23.


Wnt3a stabilised beta-catenin in the absence of the LRP6 receptor and with maintained axin and Dickkopf-1 protein expression.
1(0,0,0,1) Details
19059821 Chummun S, McLean NR, Abraham S, Youseff M: Desmoid tumour of the breast. . J Plast Reconstr Aesthet Surg. 2010 Feb;63(2):339-45. Epub 2008 Dec 6.


Immunochemistry showed strong positivity for vimentin and variable positivity for SMA and desmin, and patchy positivity for beta catenin.
1(0,0,0,1) Details
18446631 Pauli J, Gundelach R, Vanelli-Rees A, Rees G, Campbell C, Dubey S, Perry C: Juvenile nasopharyngeal angiofibroma: an immunohistochemical characterisation of the stromal cell. Pathology. 2008 Jun;40(4):396-400.


The finding of activating beta-catenin gene mutations in the stromal cells indicates these are the neoplastic cells and supports the association of JNA and familial adenomatous polyposis (FAP).
1(0,0,0,1) Details
19304912 Dasgupta C, Sakurai R, Wang Y, Guo P, Ambalavanan N, Torday JS, Rehan VK: Hyperoxia-induced neonatal rat lung injury involves activation of TGF-{beta} and Wnt signaling and is protected by rosiglitazone. Am J Physiol Lung Cell Mol Physiol. 2009 Jun;296(6):L1031-41. Epub 2009 Mar 20.


Our study revealed that hyperoxia caused significant upregulation of Wnt signaling protein markers lymphoid enhancer factor 1 (Lef-1) and beta-catenin and TGF-beta pathway transducers phosphorylated Smad3 and Smad7 proteins in whole rat lung extracts.
1(0,0,0,1) Details