Protein Information

Name S1P
Synonyms MBTPS 1; MBTPS1; MBTPS1 protein; Membrane bound transcription factor site 1 protease precursor; Membrane bound transcription factor site 1 protease; PCSK 8; PCSK8; S1P…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
18687328 Swaney JS, Moreno KM, Gentile AM, Sabbadini RA, Stoller GL: Sphingosine-1-phosphate (S1P) is a novel fibrotic mediator in the eye. . Exp Eye Res. 2008 Oct;87(4):367-75. Epub 2008 Jul 18.

11(0,0,0,11) Details
19608972 Grabski AD, Shimizu T, Deou J, Mahoney WM Jr, Reidy MA, Daum G: Sphingosine-1-phosphate receptor-2 regulates expression of smooth muscle alpha-actin after arterial injury. Arterioscler Thromb Vasc Biol. 2009 Oct;29(10):1644-50. Epub 2009 Jul 16.


At various time points after injury, expression of multiple SMC differentiation genes, myocardin, and S1P receptors (S1P1R, S1P2R, and S1P3R) was measured by quantitative PCR.
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19337690 Nincheri P, Luciani P, Squecco R, Donati C, Bernacchioni C, Borgognoni L, Luciani G, Benvenuti S, Francini F, Bruni P: Sphingosine 1-phosphate induces differentiation of adipose tissue-derived mesenchymal stem cells towards smooth muscle cells. Cell Mol Life Sci. 2009 May;66(10):1741-54.


Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid which regulates multiple biological parameters in a number of cell types, including stem cells.
5(0,0,0,5) Details
17641298 Kono Y, Nishiuma T, Nishimura Y, Kotani Y, Okada T, Nakamura S, Yokoyama M: Sphingosine kinase 1 regulates differentiation of human and mouse lung fibroblasts mediated by TGF-beta1. Am J Respir Cell Mol Biol. 2007 Oct;37(4):395-404. Epub 2007 Jul 19.


We also detected activation of Rho GTPase upon stimulation of TGF-beta1 on the cell membrane where S1P (2) or S1P (3) was overexpressed.
2(0,0,0,2) Details
19015263 Jin L, Yoshida T, Ho R, Owens GK, Somlyo AV: The actin-associated protein Palladin is required for development of normal contractile properties of smooth muscle cells derived from embryoid bodies. J Biol Chem. 2009 Jan 23;284(4):2121-30. Epub 2008 Nov 17.


Importantly, Palladin null APSCs within collagen gels generated less maximum contractile force when stimulated with endothelin-1, sphingosine 1-phosphate (S1P), and thrombin.
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