Protein Information

Name acetolactate synthase
Synonyms Acetolactate synthase; OR10B1P

Compound Information

Name imazethapyr
CAS

Reference List

PubMed Abstract RScore(About this table)
16668171 Subramanian MV, Loney-Gallant V, Dias JM, Mireles LC: Acetolactate Synthase Inhibiting Herbicides Bind to the Regulatory Site. Plant Physiol. 1991 May;96(1):310-313.

Dual inhibition analyses of triazolopyrimidine sulfonanilide, thifensulfuron, and imazethapyr versus feedback inhibitor leucine revealed that the three herbicides were competitive with the amino acid for binding to acetolactate synthase from wild-type cotton cultures.
84(1,1,1,4) Details
11975725 Gaston S, Zabalza A, Gonzalez EM, Arrese-Igor C, Aparicio-Tejo PM, Royuela M: Imazethapyr, an inhibitor of the branched-chain amino acid biosynthesis, induces aerobic fermentation in pea plants. Physiol Plant. 2002 Apr;114(4):524-532.

Acetolactate synthase (ALS; EC 4.1.3.18) inhibition is the primary mechanism of action of imazethapyr (IM).
81(1,1,1,1) Details
20218719 Zhou Q, Zhang N, Zhang C, Huang L, Niu Y, Zhang Y, Liu W: Molecular Mechanism of Enantioselective Inhibition of Acetolactate Synthase by Imazethapyr Enantiomers. J Agric Food Chem. 2010 Mar 10.
81(1,1,1,1) Details
15619733 Avila LA, Lee DJ, Senseman SA, McCauley GN, Chandler JM, Cothren JT: Assessment of acetolactate synthase (ALS) tolerance to imazethapyr in red rice ecotypes (Oryza spp) and imidazolinone tolerant/ resistant rice (Oryza sativa) varieties. Pest Manag Sci. 2005 Feb;61(2):171-8.
18(0,0,3,3) Details
15499910 Ray K, Jagannath A, Gangwani SA, Burma PK, Pental D: Mutant acetolactate synthase gene is an efficient in vitro selectable marker for the genetic transformation of Brassica juncea (oilseed mustard). J Plant Physiol. 2004 Sep;161(9):1079-83.

The ALS enzyme is inhibited by two categories of herbicides, sulfonylureas (e.g. chlorsulfuron) and imidazolinones (e.g. imazethapyr), while the mutant forms are resistant to the same.
2(0,0,0,2) Details
15656167 Trezzi MM, Felippi CL, Mattei D, Silva HL, Nunes AL, Debastiani C, Vidal RA, Marques A: Multiple resistance of acetolactate synthase and protoporphyrinogen oxidase inhibitors in Euphorbia heterophylla biotypes. J Environ Sci Health B. 2005;40(1):101-9.

In the greenhouse experiment samples of each population were sprayed with imazethapyr or fomesafen, at only one rate.
2(0,0,0,2) Details
16455361 Trucco F, Hager AG, Tranel PJ: Acetolactate synthase mutation conferring imidazolinone-specific herbicide resistance in Amaranthus hybridus. J Plant Physiol. 2006 Mar;163(4):475-9. Epub 2005 Sep 12.

In vitro inhibition of enzymatic activity (I (50)) required 1000-fold greater concentration of imazethapyr in the resistant population compared with a susceptible control.
2(0,0,0,2) Details
14576285 Gaston S, Ribas-Carbo M, Busquets S, Berry JA, Zabalza A, Royuela M: Changes in mitochondrial electron partitioning in response to herbicides inhibiting branched-chain amino acid biosynthesis in soybean. Plant Physiol. 2003 Nov;133(3):1351-9. Epub 2003 Oct 23.


Merr. cv Ransom) treated with herbicides that inhibit the enzyme acetolactate synthase (ALS) was analyzed.
1(0,0,0,1) Details
16159177 Zabalza A, Gonzalez EM, Arrese-Igor C, Royuela M: Fermentative metabolism is induced by inhibiting different enzymes of the branched-chain amino acid biosynthesis pathway in pea plants. J Agric Food Chem. 2005 Sep 21;53(19):7486-93.

Chlorsulfuron and imazethapyr (inhibitors of acetolactate synthase, ALS, EC 4.1.3.18) produced a strong induction of pyruvate decarboxylase (PDC, EC 4.1.1.1) and alcohol dehydrogenase (ADH, EC 1.1.1.1) activities and a lesser induction of lactate dehydrogenase (LDH, EC 1.1.1.27) and alanine aminotransferase (AlaAT, EC 2.6.1.2) activities in roots.
Chlorsulfuron and imazethapyr (inhibitors of acetolactate synthase, ALS, EC 4.1.3.18) produced a strong induction of pyruvate decarboxylase (PDC, EC 4.1.1.1) and alcohol dehydrogenase (ADH, EC 1.1.1.1) activities and a lesser induction of lactate dehydrogenase (LDH, EC 1.1.1.27) and alanine aminotransferase (AlaAT, EC 2.6.1.2) activities in roots.
1(0,0,0,1) Details
14620047 Osuna MD, Fischer AJ, De Prado R: Herbicide resistance in Aster squamatus conferred by a less sensitive form of acetolactate synthase. Pest Manag Sci. 2003 Nov;59(11):1210-6.

Cross-resistance existed for the ALS-inhibitors imazamox, imazethapyr, amidosulfuron, nicosulfuron, rimsulfuron, triasulfuron and tribenuron, but not for bensulfuron.
1(0,0,0,1) Details
19918955 Orcaray L, Igal M, Marino D, Zabalza A, Royuela M: The possible role of quinate in the mode of action of glyphosate and acetolactate synthase inhibitors. Pest Manag Sci. 2010 Mar;66(3):262-9.

Imazethapyr and chlorsulfuron are two herbicides that act by inhibiting branched-chain amino acid biosynthesis.
1(0,0,0,1) Details