| Name | ATPases |
|---|---|
| Synonyms | (NA+ + K+)ATPase; ATP1A1; ATPase; ATPase Na+/K+ transporting alpha 1 polypeptide; Na (+) K (+) ATPase; Na (+),K (+) ATPase; Na + K + ATPase; Na K + ATPase… |
| Name | ferrous sulfate |
|---|---|
| CAS | sulfuric acid iron(2+) salt (1:1) |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8619892 | Rohn TT, Hinds TR, Vincenzi FF: Inhibition of Ca2+-pump ATPase and the Na+/K+-pump ATPase by iron-generated free radicals. Biochem Pharmacol. 1996 Feb 23;51(4):471-6. Preincubation of red blood cell (RBC) membranes with a model system known to generate reactive species (ROS) and free radicals (200 microM ferrous sulfate and 200 microM EDTA, Fe2+/EDTA) resulted inhibition of the Na+/K+ -pump ATPases was also associated with membrane protein crosslinking and lipid peroxidation, the latter as monitored by the formation of thiobarbituric acid reactive substances (TBARS). |
82(1,1,1,2) | Details |
| 8394084 | Rohn TT, Hinds TR, Vincenzi FF: Ion transport ATPases as targets for free radical damage. Biochem Pharmacol. 1993 Aug 3;46(3):525-34. Preincubation of red blood cell membranes in the presence of ferrous sulfate and EDTA resulted in both a concentration- and time-dependent inhibition of the Na+/K+ pump ATPase, basal Ca2+ pump ATPase, and the calmodulin- (CaM) activated Ca2+ pump ATPase. |
6(0,0,0,6) | Details |
| 8080446 | Wei N, Sadrzadeh SM: Enhancement of hemin-induced membrane damage by artemisinin. Biochem Pharmacol. 1994 Aug 17;48(4):737-41. Desferrioxamine (DFO, 200 microM) blocked significantly the effect of iron--artemisinin on ATPases (P < 0.01). |
2(0,0,0,2) | Details |
| 9276486 | Keller JN, Mark RJ, Bruce AJ, Blanc E, Rothstein JD, Uchida K, Waeg G, Mattson MP: an aldehydic product of membrane lipid peroxidation, impairs transport and mitochondrial function in synaptosomes. Neuroscience. 1997 Oct;80(3):685-96. Although cell culture data indicate that oxidative insults can impair key membrane regulatory systems including ion-motive ATPases and amino acid transport systems, the effects of oxidative stress on synapses, and the mechanisms that mediate such effects, are largely unknown. |
1(0,0,0,1) | Details |
| 10905541 | Agil A, Sadrzadeh SM: -urea protects erythrocytes against oxidative damage. Redox Rep. 2000;5(1):29-34. Intact RBCs or RBC membranes were exposed to t-butyl hydroperoxide (t-BHP, 0.75 mM) or iron (ferrous sulfate; 100 microM) at 37 degrees C for 60 min in the presence or absence of OH-U (1.25 mM). The extent of oxidative damage was measured by LPO (as thiobarbituric acid reactive substances, TBARS), hemoglobin oxidation (as percent of methemoglobin, metHb %), and decrease in the activities of membrane-bound Na+/K+-ATPase and Ca2+-ATPases. |
1(0,0,0,1) | Details |